CA2491887C - Modified inosine monophosphate dehydrogenases - Google Patents
Modified inosine monophosphate dehydrogenases Download PDFInfo
- Publication number
- CA2491887C CA2491887C CA2491887A CA2491887A CA2491887C CA 2491887 C CA2491887 C CA 2491887C CA 2491887 A CA2491887 A CA 2491887A CA 2491887 A CA2491887 A CA 2491887A CA 2491887 C CA2491887 C CA 2491887C
- Authority
- CA
- Canada
- Prior art keywords
- impdh
- seq
- ala
- gly
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108020005199 Dehydrogenases Proteins 0.000 title description 6
- 229920001184 polypeptide Polymers 0.000 claims abstract description 166
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 166
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 166
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- 102000039446 nucleic acids Human genes 0.000 claims abstract description 100
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- 241000588724 Escherichia coli Species 0.000 claims description 13
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- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 abstract description 271
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| US10/769,481 US7276362B2 (en) | 2004-01-30 | 2004-01-30 | Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides |
| US10/769,481 | 2004-01-30 |
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| CA2491887A1 CA2491887A1 (en) | 2005-07-30 |
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| CA2491887A Expired - Lifetime CA2491887C (en) | 2004-01-30 | 2005-01-27 | Modified inosine monophosphate dehydrogenases |
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| AT (1) | ATE424451T1 (enExample) |
| CA (1) | CA2491887C (enExample) |
| DE (1) | DE602005013013D1 (enExample) |
| DK (1) | DK1559779T3 (enExample) |
| ES (1) | ES2322477T3 (enExample) |
| PL (1) | PL1559779T3 (enExample) |
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| US7473541B2 (en) * | 2004-07-09 | 2009-01-06 | Gross Richard W | Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities |
| US7183106B1 (en) * | 2004-05-28 | 2007-02-27 | The United States Of America As Represented By The United States Department Of Energy | Bacterial inosine 5′-monophosphate dehydrogenase (“IMPDH”) DNA as a dominant selectable marker in mammals and other eukaryotes |
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| US4215051A (en) | 1979-08-29 | 1980-07-29 | Standard Oil Company (Indiana) | Formation, purification and recovery of phthalic anhydride |
| US5047513A (en) | 1986-07-10 | 1991-09-10 | Hoffmann-La Roche Inc. | Metal chelate resins |
| CA1304886C (en) | 1986-07-10 | 1992-07-07 | Heinz Dobeli | Metal chelate resins |
| CA1340522C (en) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| US5665583A (en) | 1988-08-12 | 1997-09-09 | Arch Dev Corp | Methods and materials relating to IMPDH and GMP production |
| US5283257A (en) | 1992-07-10 | 1994-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating hyperproliferative vascular disease |
| WO1994012184A1 (en) | 1992-11-24 | 1994-06-09 | Syntex (U.S.A.) Inc. | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| US5444072A (en) | 1994-02-18 | 1995-08-22 | Syntex (U.S.A.) Inc. | 6-substituted mycophenolic acid and derivatives |
| US5380879A (en) | 1994-02-18 | 1995-01-10 | Syntex (U.S.A.) Inc. | Derivatives of mycophenolic acid |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6128582A (en) | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
| DE19811313A1 (de) | 1998-03-16 | 1999-09-23 | Merckle Gmbh | Verfahren zur Bestimmung der Aktivität von Inosin 5'-monophosphat dehydrogenase |
| US6451572B1 (en) | 1998-06-25 | 2002-09-17 | Cornell Research Foundation, Inc. | Overexpression of phytase genes in yeast systems |
| US6107052A (en) | 1999-06-09 | 2000-08-22 | Roche Diagnostics Corporation | Enzymatic measurement of mycophenolic acid |
| US6524808B1 (en) | 1999-06-25 | 2003-02-25 | Roche Diagnostics Corporation | Enzyme inhibition immunoassay |
| PL354805A1 (en) | 1999-11-18 | 2004-02-23 | Cornell Research Foundation, Inc. | Site-directed mutagenesis of escherichia coli |
| CA2408921A1 (en) | 2000-05-10 | 2001-11-15 | Bristol-Myers Squibb Company | Modified inosine 5'-monophosphate dehydrogenase polypeptides and uses thereof |
| DE60140929D1 (de) | 2000-11-14 | 2010-02-11 | Roche Diagnostics Gmbh | Immunoassay für HIV-Protease-Hemstoffe |
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2004
- 2004-01-30 US US10/769,481 patent/US7276362B2/en not_active Expired - Lifetime
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2005
- 2005-01-25 PL PL05001460T patent/PL1559779T3/pl unknown
- 2005-01-25 EP EP05001460A patent/EP1559779B1/en not_active Expired - Lifetime
- 2005-01-25 AT AT05001460T patent/ATE424451T1/de active
- 2005-01-25 ES ES05001460T patent/ES2322477T3/es not_active Expired - Lifetime
- 2005-01-25 DK DK05001460T patent/DK1559779T3/da active
- 2005-01-25 DE DE602005013013T patent/DE602005013013D1/de not_active Expired - Lifetime
- 2005-01-27 CA CA2491887A patent/CA2491887C/en not_active Expired - Lifetime
- 2005-01-27 JP JP2005019619A patent/JP4597689B2/ja not_active Expired - Lifetime
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2007
- 2007-06-20 US US11/820,662 patent/US7531336B2/en not_active Expired - Lifetime
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2010
- 2010-03-10 JP JP2010053103A patent/JP2010119395A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2322477T3 (es) | 2009-06-22 |
| US7531336B2 (en) | 2009-05-12 |
| ATE424451T1 (de) | 2009-03-15 |
| US20080026424A1 (en) | 2008-01-31 |
| EP1559779B1 (en) | 2009-03-04 |
| JP4597689B2 (ja) | 2010-12-15 |
| US7276362B2 (en) | 2007-10-02 |
| DE602005013013D1 (de) | 2009-04-16 |
| EP1559779A1 (en) | 2005-08-03 |
| DK1559779T3 (da) | 2009-06-22 |
| CA2491887A1 (en) | 2005-07-30 |
| US20050202520A1 (en) | 2005-09-15 |
| JP2010119395A (ja) | 2010-06-03 |
| PL1559779T3 (pl) | 2009-08-31 |
| JP2005218447A (ja) | 2005-08-18 |
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