CA2489343C - Corneal topography-based target warping - Google Patents
Corneal topography-based target warping Download PDFInfo
- Publication number
- CA2489343C CA2489343C CA2489343A CA2489343A CA2489343C CA 2489343 C CA2489343 C CA 2489343C CA 2489343 A CA2489343 A CA 2489343A CA 2489343 A CA2489343 A CA 2489343A CA 2489343 C CA2489343 C CA 2489343C
- Authority
- CA
- Canada
- Prior art keywords
- shape
- eye
- virtual
- laser beam
- ablation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000012876 topography Methods 0.000 title claims description 31
- 238000002679 ablation Methods 0.000 claims abstract description 86
- 238000011282 treatment Methods 0.000 claims abstract description 74
- 210000004087 cornea Anatomy 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 44
- 210000001747 pupil Anatomy 0.000 claims abstract description 25
- 230000004044 response Effects 0.000 claims abstract description 15
- 230000003287 optical effect Effects 0.000 claims description 44
- 238000005259 measurement Methods 0.000 claims description 35
- 230000004075 alteration Effects 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- 238000004590 computer program Methods 0.000 claims description 11
- 230000007547 defect Effects 0.000 claims description 4
- 238000013507 mapping Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 98
- 239000013598 vector Substances 0.000 description 37
- 238000001356 surgical procedure Methods 0.000 description 11
- 238000012937 correction Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 238000013532 laser treatment Methods 0.000 description 7
- 208000014733 refractive error Diseases 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 238000000608 laser ablation Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 201000009310 astigmatism Diseases 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 206010020675 Hypermetropia Diseases 0.000 description 2
- ISQINHMJILFLAQ-UHFFFAOYSA-N argon hydrofluoride Chemical compound F.[Ar] ISQINHMJILFLAQ-UHFFFAOYSA-N 0.000 description 2
- 201000006318 hyperopia Diseases 0.000 description 2
- 230000004305 hyperopia Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 238000002430 laser surgery Methods 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 101100234408 Danio rerio kif7 gene Proteins 0.000 description 1
- 101100221620 Drosophila melanogaster cos gene Proteins 0.000 description 1
- 101100398237 Xenopus tropicalis kif11 gene Proteins 0.000 description 1
- 238000011298 ablation treatment Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 101150118300 cos gene Proteins 0.000 description 1
- 230000003500 cycloplegic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000029436 dilated pupil Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
- RIUWBIIVUYSTCN-UHFFFAOYSA-N trilithium borate Chemical compound [Li+].[Li+].[Li+].[O-]B([O-])[O-] RIUWBIIVUYSTCN-UHFFFAOYSA-N 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00804—Refractive treatments
- A61F9/00806—Correction of higher orders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
- A61F2009/00848—Feedback systems based on wavefront
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00878—Planning
- A61F2009/0088—Planning based on wavefront
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00878—Planning
- A61F2009/00882—Planning based on topography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00804—Refractive treatments
- A61F9/00808—Inducing higher orders, e.g. for correction of presbyopia
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38909002P | 2002-06-13 | 2002-06-13 | |
| US60/389,090 | 2002-06-13 | ||
| PCT/US2003/018750 WO2003105722A2 (en) | 2002-06-13 | 2003-06-12 | Corneal topography-based target warping |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2489343A1 CA2489343A1 (en) | 2003-12-24 |
| CA2489343C true CA2489343C (en) | 2013-10-01 |
Family
ID=29736587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2489343A Expired - Fee Related CA2489343C (en) | 2002-06-13 | 2003-06-12 | Corneal topography-based target warping |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7083609B2 (enExample) |
| EP (1) | EP1534161B1 (enExample) |
| JP (1) | JP2005529681A (enExample) |
| CA (1) | CA2489343C (enExample) |
| WO (1) | WO2003105722A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003102498A1 (en) | 2002-05-30 | 2003-12-11 | Visx, Inc. | “tracking torsional eye orientation and position” |
| US7083609B2 (en) * | 2002-06-13 | 2006-08-01 | Visx, Incorporated | Corneal topography-based target warping |
| US7458683B2 (en) * | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
| US7481536B2 (en) * | 2004-02-19 | 2009-01-27 | Amo Manufacturing Usa, Llc | Methods and systems for differentiating left and right eye images |
| EP1848389B1 (de) * | 2005-02-15 | 2011-07-20 | Carl Zeiss Meditec AG | Verfahren zur herstellung eines ablationsprogramms, in abhängigkeit von der form eines laserstrahlprofils und von einer neigung der zu ablatierenden oberfläche ; mittel zur durchführung der verfahren |
| EP1871262B1 (en) * | 2005-04-14 | 2013-06-12 | University Of Rochester | System for treating vision refractive errors |
| US7207983B2 (en) * | 2005-04-29 | 2007-04-24 | University Of Florida Research Foundation, Inc. | System and method for real-time feedback of ablation rate during laser refractive surgery |
| US20080065052A1 (en) * | 2005-10-14 | 2008-03-13 | Carl Zeiss Meditec Ag | Device and method for material processing by means of laser radiation |
| US8553735B2 (en) * | 2005-10-14 | 2013-10-08 | Carl Zeiss Meditec Ag | Device and method for material processing by means of laser radiation |
| US9956230B2 (en) | 2005-10-19 | 2018-05-01 | Michael Mehrdad Mazaheri | Method for visual enhancement and post procedure treatment protocol |
| US9192517B2 (en) * | 2005-10-19 | 2015-11-24 | Michael M. Mazaheri | Mazaheri LASIK method for visual enhancement |
| US10512653B2 (en) | 2005-10-19 | 2019-12-24 | Michael Mehrdad Mazaheri | Method for visual enhancement and post procedure treatment protocol |
| US9286272B2 (en) * | 2005-12-22 | 2016-03-15 | Xerox Corporation | Method for transformation of an extensible markup language vocabulary to a generic document structure format |
| ES2389957T3 (es) | 2006-03-15 | 2012-11-05 | Wavelight Gmbh | Programa de control para cirugía oftalmológica |
| US8216214B2 (en) * | 2007-03-12 | 2012-07-10 | Ethicon Endo-Surgery, Inc. | Power modulation of a scanning beam for imaging, therapy, and/or diagnosis |
| EP1985269B1 (de) * | 2007-04-25 | 2011-07-27 | WaveLight GmbH | Vorrichtung, Verfahren und Steuerprogramm für die refraktive Chirurgie |
| EP2144582B1 (en) * | 2007-05-11 | 2017-08-23 | AMO Development, LLC | Combined wavefront and topography systems and methods |
| CA2686854C (en) | 2007-05-17 | 2019-03-05 | Keith Holliday | Customized laser epithelial ablation systems and methods |
| US8377047B2 (en) * | 2007-08-01 | 2013-02-19 | Amo Development, Llc. | Systems and methods for fine-tuning refractive surgery |
| US8550625B2 (en) * | 2007-08-01 | 2013-10-08 | Amo Development, Llc | Systems and methods for fine-tuning refractive surgery |
| RU2498789C2 (ru) * | 2009-04-01 | 2013-11-20 | Уэйвлайт Гмбх | Устройство для воздействия на глаз лазерным излучением |
| DE102009030466A1 (de) * | 2009-06-23 | 2011-01-05 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zur Ausrichtung von ortsbezogenen Augendaten |
| DE102009030464B4 (de) | 2009-06-23 | 2022-04-14 | Carl Zeiss Meditec Ag | Lasergerät und Verfahren, insbesondere Betriebsverfahren für ein Lasergerät, zur Erstellung von Bestrahlungssteuerdaten für einen gepulsten Laser |
| CA2774536C (en) * | 2009-09-18 | 2017-12-12 | Amo Development, Llc | Registration of corneal flap with ophthalmic measurement and/or treatment data for lasik and other procedures |
| US8409181B2 (en) * | 2009-11-05 | 2013-04-02 | Amo Development, Llc. | Methods and systems for treating presbyopia |
| CN101810528A (zh) * | 2010-01-22 | 2010-08-25 | 温州医学院 | 用于准分子激光角膜屈光手术的角膜中心定位方法 |
| WO2012019171A1 (en) * | 2010-08-06 | 2012-02-09 | Raydiance, Inc. | Biological tissue transformation using ultrafast light |
| US20140135748A1 (en) * | 2012-11-08 | 2014-05-15 | Amo Development, Llc | Basis data apodization systems and methods |
| US10783999B2 (en) | 2010-10-05 | 2020-09-22 | Amo Development, Llc | Basis data evaluation systems and methods |
| US8978660B2 (en) | 2011-07-21 | 2015-03-17 | Amo Development, Llc | Tilt compensation, measurement, and associated adjustment of refractive prescriptions during surgical and other treatments of the eye |
| DE102011083789A1 (de) * | 2011-09-29 | 2013-04-04 | Oculus Optikgeräte GmbH | Ophthalmologisches Analyseverfahren |
| DE102012209667A1 (de) * | 2012-06-08 | 2013-12-12 | Oculus Optikgeräte GmbH | Verfahren und Analysegerät zur Messung einer Hornhaut |
| EP2705813A1 (en) * | 2012-09-05 | 2014-03-12 | Technolas Perfect Vision GmbH | Laser configuration that reduces the laser footprint and improves ergonomics |
| CN105277730B (zh) * | 2015-10-27 | 2017-11-07 | 舟山医院 | 一种外周血特异性早期肺癌诊断辅助装置 |
| AU2017311513A1 (en) | 2016-08-10 | 2019-02-14 | Amo Development, Llc | Epithelial ablation systems and methods |
| EP4267060A1 (en) * | 2020-12-24 | 2023-11-01 | Alcon Inc. | Systems and methods for ablating ophthalmic tissue |
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| US4540254A (en) | 1982-10-26 | 1985-09-10 | Humphrey Instruments, Inc. | Keratometer having peripheral light entrance and exit paths |
| US4665913A (en) | 1983-11-17 | 1987-05-19 | Lri L.P. | Method for ophthalmological surgery |
| US4761071A (en) | 1984-11-06 | 1988-08-02 | Baron William S | Apparatus and method for determining corneal and scleral topography |
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| US4995716A (en) | 1989-03-09 | 1991-02-26 | Par Technology Corporation | Method and apparatus for obtaining the topography of an object |
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| DE19904753C1 (de) * | 1999-02-05 | 2000-09-07 | Wavelight Laser Technologie Gm | Vorrichtung für die photorefraktive Hornhautchirurgie des Auges zur Korrektur von Sehfehlern höherer Ordnung |
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| CN1211045C (zh) * | 1999-10-21 | 2005-07-20 | 株式会社尼德克 | 确定角膜脱落量的装置与角膜外科手术装置 |
| US7237898B1 (en) * | 1999-10-21 | 2007-07-03 | Bausch & Lomb Incorporated | Customized corneal profiling |
| US6199986B1 (en) | 1999-10-21 | 2001-03-13 | University Of Rochester | Rapid, automatic measurement of the eye's wave aberration |
| EP1301154A2 (en) * | 2000-01-12 | 2003-04-16 | LaserSight Technologies, Inc. | Laser fluence compensation of a curved surface |
| US6673062B2 (en) | 2000-03-14 | 2004-01-06 | Visx, Inc. | Generating scanning spot locations for laser eye surgery |
| EP1235538B1 (en) * | 2000-03-22 | 2004-06-02 | Alcon, Inc. | Optimization of ablation correction of an optical system |
| DE10022995C2 (de) * | 2000-05-11 | 2003-11-27 | Wavelight Laser Technologie Ag | Vorrichtung für die photorefraktive Hornhautchirurgie |
| JP4021136B2 (ja) * | 2000-08-31 | 2007-12-12 | 株式会社ニデック | 角膜手術装置 |
| US20020049431A1 (en) * | 2000-10-20 | 2002-04-25 | Smith Michael J. | Method of correcting corneal refraction not aligned with the pupil center |
| US6730074B2 (en) * | 2002-05-24 | 2004-05-04 | 20/10 Perfect Vision Optische Geraete Gmbh | Cornea contact system for laser surgery |
| US7083609B2 (en) * | 2002-06-13 | 2006-08-01 | Visx, Incorporated | Corneal topography-based target warping |
-
2003
- 2003-06-11 US US10/460,060 patent/US7083609B2/en not_active Expired - Lifetime
- 2003-06-12 WO PCT/US2003/018750 patent/WO2003105722A2/en not_active Ceased
- 2003-06-12 JP JP2004512633A patent/JP2005529681A/ja active Pending
- 2003-06-12 CA CA2489343A patent/CA2489343C/en not_active Expired - Fee Related
- 2003-06-12 EP EP03741977.7A patent/EP1534161B1/en not_active Expired - Lifetime
-
2005
- 2005-03-31 US US11/096,536 patent/US7419485B2/en not_active Expired - Lifetime
-
2008
- 2008-07-11 US US12/172,114 patent/US7892227B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529681A (ja) | 2005-10-06 |
| US7083609B2 (en) | 2006-08-01 |
| EP1534161A2 (en) | 2005-06-01 |
| US20050171515A1 (en) | 2005-08-04 |
| CA2489343A1 (en) | 2003-12-24 |
| WO2003105722A2 (en) | 2003-12-24 |
| US20080275434A1 (en) | 2008-11-06 |
| EP1534161A4 (en) | 2010-01-20 |
| EP1534161B1 (en) | 2014-01-08 |
| US20040019346A1 (en) | 2004-01-29 |
| US7419485B2 (en) | 2008-09-02 |
| WO2003105722A3 (en) | 2005-02-17 |
| US7892227B2 (en) | 2011-02-22 |
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