CA2479908A1 - Activateurs de calcineurine - Google Patents

Activateurs de calcineurine Download PDF

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Publication number
CA2479908A1
CA2479908A1 CA002479908A CA2479908A CA2479908A1 CA 2479908 A1 CA2479908 A1 CA 2479908A1 CA 002479908 A CA002479908 A CA 002479908A CA 2479908 A CA2479908 A CA 2479908A CA 2479908 A1 CA2479908 A1 CA 2479908A1
Authority
CA
Canada
Prior art keywords
klkp
calcineurin
lys
protein
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002479908A
Other languages
English (en)
Inventor
Hiroko Kitamoto
Tokichi Miyakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Agrobiological Sciences
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2479908A1 publication Critical patent/CA2479908A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des activateurs de calcineurine contenant la protéine (a) ou (b) en tant que principe actif et augmentant la concentration intracellulaire d'ions de calcium résultant de l'affluence d'ions de calcium dans les cellules eucaryotes. (a) une protéine tueuse KLKP produite par un amidon tueur Kluyveromyces lactis qui comprend trois sous-unités qui contiennent, respectivement, les séquences d'acide aminé représentées par SEQ ID NOS:2 à 4. (b) une protéine qui comprend trois sous-unités, tout comme dans la protéine (a) susmentionnée, et qui présente l'activité de la protéine tueuse Kluyveromyces lactis (KLKP), au moins une des trois sous-unités comprenant une séquence d'acide aminé subissant une délétion, une substitution ou une addition d'un ou de plusieurs acides aminés.
CA002479908A 2002-03-22 2002-06-18 Activateurs de calcineurine Abandoned CA2479908A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002-81415 2002-03-22
JP2002081415 2002-03-22
PCT/JP2002/006063 WO2003080841A1 (fr) 2002-03-22 2002-06-18 Activateurs de calcineurine

Publications (1)

Publication Number Publication Date
CA2479908A1 true CA2479908A1 (fr) 2003-10-02

Family

ID=28449120

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002479908A Abandoned CA2479908A1 (fr) 2002-03-22 2002-06-18 Activateurs de calcineurine

Country Status (3)

Country Link
JP (1) JP4500991B2 (fr)
CA (1) CA2479908A1 (fr)
WO (1) WO2003080841A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6860922B2 (ja) * 2016-02-12 2021-04-21 国立大学法人 岡山大学 免疫機能の検査方法、がん患者の選別方法、がんの治療効果予測方法、細胞内カルシウムイオン濃度上昇剤、腫瘍組織におけるエフェクター・メモリー（ＥＭ）とエフェクター（ｅｆｆ）の選択的機能向上剤、がん治療薬の効果のモニタリング方法

Also Published As

Publication number Publication date
WO2003080841A1 (fr) 2003-10-02
WO2003080841A8 (fr) 2003-12-04
JP4500991B2 (ja) 2010-07-14
JPWO2003080841A1 (ja) 2005-07-28

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