CA2479270C - Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec) - Google Patents

Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec) Download PDF

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Publication number
CA2479270C
CA2479270C CA2479270A CA2479270A CA2479270C CA 2479270 C CA2479270 C CA 2479270C CA 2479270 A CA2479270 A CA 2479270A CA 2479270 A CA2479270 A CA 2479270A CA 2479270 C CA2479270 C CA 2479270C
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CA
Canada
Prior art keywords
antibody
aeec
antibodies
egg
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2479270A
Other languages
English (en)
Other versions
CA2479270A1 (fr
Inventor
John M. Fairbrother
Josee Harel
Isabelle Batisson
Francis Girard
Marie-Pierre Guimond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Canada Ltd
Original Assignee
Valorisation-Recherche LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002339436A external-priority patent/CA2339436A1/fr
Application filed by Valorisation-Recherche LP filed Critical Valorisation-Recherche LP
Priority to CA2479270A priority Critical patent/CA2479270C/fr
Publication of CA2479270A1 publication Critical patent/CA2479270A1/fr
Application granted granted Critical
Publication of CA2479270C publication Critical patent/CA2479270C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des anticorps immunologiquement sp~cifiques de prot~ine associ~e ~ la virulence de souches d'Escherichia coli attachantes et effa×antes (AEEC), des produits, des compositions contenant ces anticorps, ainsi que leurs proc~d~s d'utilisation dans la pr~vention d'une infection par AEEC chez un mammif­re. L'anticorps de l'invention est immunologiquement sp~cifique d'une prot~ine associ~e ~ la virulence d'AEEC et, administr~ ~ un mammif­re, permet d'~viter une infection intestinale due ~ une souche d'AEEC in vivo. Cet anticorps est utilis~, de pr~f~rence, pour la pr~vention du d~veloppement de l~sions intestinales d'attachement/effacement associ~es ~ une souche d'AEEC. On obtient ce r~sultat en utilisant, de pr~f~rence, des anticorps lgY immunologiquement sp~cifiques pour une ou plusieurs prot~ines associ~es ~ la virulence d'AEEC, notamment les prot~ines Eae, Tir, EspA et Paa.
CA2479270A 2001-03-15 2002-03-14 Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec) Expired - Lifetime CA2479270C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2479270A CA2479270C (fr) 2001-03-15 2002-03-14 Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,339,436 2001-03-15
CA002339436A CA2339436A1 (fr) 2001-03-15 2001-03-15 Production d'anticorps contre les facteurs de virulence associes aux souches d'escherichia coli aeec, et leur utilisation
CA2479270A CA2479270C (fr) 2001-03-15 2002-03-14 Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec)
PCT/CA2002/000353 WO2002074812A2 (fr) 2001-03-15 2002-03-14 Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effaçantes(aeec)

Publications (2)

Publication Number Publication Date
CA2479270A1 CA2479270A1 (fr) 2002-09-26
CA2479270C true CA2479270C (fr) 2010-07-27

Family

ID=34063992

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2479270A Expired - Lifetime CA2479270C (fr) 2001-03-15 2002-03-14 Anticorps pour la prevention et le traitement contre les maladies associees a des souches d'escherichia coli attachantes et effayantes(aeec)

Country Status (1)

Country Link
CA (1) CA2479270C (fr)

Also Published As

Publication number Publication date
CA2479270A1 (fr) 2002-09-26

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