CA2477714C - New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament - Google Patents

New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament Download PDF

Info

Publication number
CA2477714C
CA2477714C CA2477714A CA2477714A CA2477714C CA 2477714 C CA2477714 C CA 2477714C CA 2477714 A CA2477714 A CA 2477714A CA 2477714 A CA2477714 A CA 2477714A CA 2477714 C CA2477714 C CA 2477714C
Authority
CA
Canada
Prior art keywords
acid
enantiomers
formula
salts
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2477714A
Other languages
English (en)
French (fr)
Other versions
CA2477714A1 (en
Inventor
Rainer Soyka
Guenter Linz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002109243 external-priority patent/DE10209243A1/de
Priority claimed from DE2002116124 external-priority patent/DE10216124A1/de
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of CA2477714A1 publication Critical patent/CA2477714A1/en
Application granted granted Critical
Publication of CA2477714C publication Critical patent/CA2477714C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2477714A 2002-03-04 2003-02-19 New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament Expired - Fee Related CA2477714C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE2002109243 DE10209243A1 (de) 2002-03-04 2002-03-04 Neue Arzneimittelkombination zur Inhalation
DE10209243.5 2002-03-04
DE10216124.0 2002-04-12
DE2002116124 DE10216124A1 (de) 2002-04-12 2002-04-12 Neue Zimtsäuresalze, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
PCT/EP2003/001644 WO2003074469A1 (de) 2002-03-04 2003-02-19 Neue zimtsäuresalze, verfahren zu deren herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
CA2477714A1 CA2477714A1 (en) 2003-09-12
CA2477714C true CA2477714C (en) 2011-01-25

Family

ID=27789722

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2477714A Expired - Fee Related CA2477714C (en) 2002-03-04 2003-02-19 New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament

Country Status (9)

Country Link
EP (1) EP1483231A1 (es)
JP (1) JP2005519110A (es)
AR (1) AR038622A1 (es)
AU (1) AU2003221482A1 (es)
CA (1) CA2477714C (es)
PE (1) PE20030933A1 (es)
TW (1) TW200404759A (es)
UY (1) UY27686A1 (es)
WO (1) WO2003074469A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2265276B1 (es) * 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
GB8310477D0 (en) * 1983-04-18 1983-05-25 Glaxo Group Ltd Chemical compounds
US4791108A (en) * 1987-04-13 1988-12-13 Syntex (U.S.A.) Inc. Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers
IL95590A (en) * 1989-09-08 1996-06-18 Glaxo Group Ltd Medicinal preparations containing Salmetrol and Pluticasone Propionate
RU2081108C1 (ru) * 1991-10-16 1997-06-10 Циба-Гейги АГ Аддитивные соли кислот с основанием и фармацевтическая композиция, обладающая противоопухолевой активностью

Also Published As

Publication number Publication date
AR038622A1 (es) 2005-01-19
CA2477714A1 (en) 2003-09-12
JP2005519110A (ja) 2005-06-30
EP1483231A1 (de) 2004-12-08
PE20030933A1 (es) 2003-12-15
AU2003221482A1 (en) 2003-09-16
UY27686A1 (es) 2003-10-31
TW200404759A (en) 2004-04-01
WO2003074469A1 (de) 2003-09-12

Similar Documents

Publication Publication Date Title
CA2506109A1 (en) Novel dihydroxy-methylphenyl derivatives, method for the production and use thereof as medicaments
US20080132556A1 (en) 3-hydroxymethyl-4hydroxy-phenyl- derivatives for the treatment of respiratory diseases
CA2506082C (en) Novel medicaments for the treatment of chronic obstructive pulmonary disease
AU2003210172B2 (en) Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals
CA2501055A1 (en) Novel betamimetics with extended duration of action, method for production and use thereof as medicaments
US8044046B2 (en) Medicaments for the treatment of chronic obstructive pulmonary disease
AU2003206760B8 (en) Anticholinergic agents, method for producing the same and use thereof as medicaments
CA2471578C (en) Xanthene-carboxylic acid esters of tropenol and scopine as m3 antagonists, method for producing the same and use thereof as medicaments
US7244728B2 (en) Long acting betamimetics for the treatment of respiratory diseases
US6680345B2 (en) Salicylic acid salts of salmeterol
US6756508B2 (en) Cinnamic acid salts, processes for their preparation, and their use as medicaments
CA2477714C (en) New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament
CA2482637C (en) New esters of hydroxy-substituted nitrogen heterocycles as antagonists of the muscarinic m3 receptor, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
CA2460440A1 (en) Salicylic acid salts, processes for preparing them and their use as pharmaceutical compositions
US7563806B2 (en) Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament
US7405232B2 (en) Long acting beta-2 agonists and their use as medicaments
CA2476746A1 (en) Difurylglycolic acid tropenol esters used as anticholinesterase drugs
DE10216124A1 (de) Neue Zimtsäuresalze, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE10216125A1 (de) Salicylsäuresalze, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ZA200404366B (en) Novel fluorene carboxylic acid esters methods for the production thereof and use of the same as pharmaceuticals

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140219