CA2474852A1 - Use of pde5 inhibitors in the treatment of scarring and fibrosis - Google Patents
Use of pde5 inhibitors in the treatment of scarring and fibrosis Download PDFInfo
- Publication number
- CA2474852A1 CA2474852A1 CA002474852A CA2474852A CA2474852A1 CA 2474852 A1 CA2474852 A1 CA 2474852A1 CA 002474852 A CA002474852 A CA 002474852A CA 2474852 A CA2474852 A CA 2474852A CA 2474852 A1 CA2474852 A1 CA 2474852A1
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- Prior art keywords
- fibrosis
- inhibitor
- scarring
- chronic
- ageing
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Classifications
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- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
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- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0202254.9A GB0202254D0 (en) | 2002-01-31 | 2002-01-31 | Prevention of scarring |
| GB0202254.9 | 2002-01-31 | ||
| PCT/IB2003/000134 WO2003063875A1 (en) | 2002-01-31 | 2003-01-21 | Use of pde5 inhibitors in the treatment of scarring and fibrosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2474852A1 true CA2474852A1 (en) | 2003-08-07 |
Family
ID=9930135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002474852A Abandoned CA2474852A1 (en) | 2002-01-31 | 2003-01-21 | Use of pde5 inhibitors in the treatment of scarring and fibrosis |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1469857A1 (enExample) |
| JP (1) | JP2005523263A (enExample) |
| BR (1) | BR0307410A (enExample) |
| CA (1) | CA2474852A1 (enExample) |
| GB (1) | GB0202254D0 (enExample) |
| MX (1) | MXPA04007430A (enExample) |
| TW (1) | TW200302105A (enExample) |
| WO (1) | WO2003063875A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2525946C (en) * | 2003-05-22 | 2013-01-29 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a pde5 inhibitor |
| WO2006023603A2 (en) | 2004-08-17 | 2006-03-02 | The Johns Hopkins University | Pde5 inhibitor compositions and methods for treating cardiac indications |
| WO2006018088A1 (en) * | 2004-08-19 | 2006-02-23 | Switch Biotech Ag | Use of a pde 5 inhibitor for treating and preventing hypopigmentary disorders |
| DE602004022463D1 (de) * | 2004-08-19 | 2009-09-17 | Switch Biotech Llc | Verwendung eines PDE5-Hemmers zur Behandlung und Vorbeugung von Hypopigmentierungsstörungen |
| EP1838319B1 (en) * | 2005-01-07 | 2018-03-07 | The Johns Hopkins University | Pde5 inhibitor compositions and methods for immunotherapy |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| EP1874316A1 (en) * | 2005-04-18 | 2008-01-09 | Associazione Foresta Per La Ricerca Nella Riproduzione Umana | Use of pde-5 inhibitors for endothelial repair of tissues impaired by trauma or disease |
| WO2006132460A1 (en) | 2005-06-10 | 2006-12-14 | Dong-A Pharmaceutical.Co., Ltd. | Agent for the prevention and treatment of liver diseases containing pyrazolopyrimidine derivative |
| AR079451A1 (es) | 2009-12-18 | 2012-01-25 | Nycomed Gmbh | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
| JP2013523809A (ja) * | 2010-04-05 | 2013-06-17 | エスケー ケミカルズ カンパニー リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| MY170094A (en) * | 2010-05-26 | 2019-07-05 | Adverio Pharma Gmbh | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc). |
| JP2014526461A (ja) * | 2011-09-09 | 2014-10-06 | エスケー ケミカルズ カンパニー，リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
| WO2014100733A1 (en) | 2012-12-21 | 2014-06-26 | Mayo Foundation For Medical Education And Research | Methods and materials for treating calcific aortic valve stenosis |
| TW201613600A (en) * | 2014-09-02 | 2016-04-16 | Jansfat Biotechnology Co Ltd | Piperazinyl derivative reduces HFD-induced accumulation of fat in the liver, therapeutically |
| EP3595623B1 (en) | 2017-03-14 | 2024-05-01 | Atir Holding S.A. | Topical formulation for the treatment of pigmented skin |
| EP4166129A1 (en) | 2017-03-14 | 2023-04-19 | Atir Holding S.A. | Use of heterocyclic compounds in the treatment of aged skin |
| MX2017016930A (es) * | 2017-12-19 | 2019-06-20 | Malesil Research & Tech Llc | Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico. |
| EP3952992A4 (en) | 2019-04-10 | 2023-04-19 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR GENDER-BASED TREATMENT OF CARDIOVASCULAR DYSFUNCTION |
| CN112773898A (zh) * | 2019-11-11 | 2021-05-11 | 广州华真医药科技有限公司 | 磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用 |
| AU2022325803A1 (en) * | 2021-08-13 | 2024-03-28 | Goldberg, David J. | Methods and compositions for treating fibrotic liver conditions, using udenafil compositions |
Family Cites Families (7)
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|---|---|---|---|---|
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US5965501A (en) * | 1997-03-28 | 1999-10-12 | Lever Brothers Company, Division Of Conopco, Inc. | Personal washing bar compositions comprising emollient rich phase/stripe |
| AU5067098A (en) * | 1997-11-26 | 1999-06-15 | Mochida Pharmaceutical Co., Ltd. | Pyridocarbazole derivatives with cgmp-pde inhibitory activity |
| ZA9810766B (en) * | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
| GB9909135D0 (en) * | 1999-04-22 | 1999-06-16 | Univ Wales Medicine | Cystic fibrosis medicaments |
| CA2323008C (en) * | 1999-10-11 | 2005-07-12 | Pfizer Inc. | Pharmaceutically active compounds |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
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2002
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- 2003-01-21 WO PCT/IB2003/000134 patent/WO2003063875A1/en not_active Ceased
- 2003-01-21 BR BR0307410-2A patent/BR0307410A/pt not_active IP Right Cessation
- 2003-01-21 JP JP2003563565A patent/JP2005523263A/ja active Pending
- 2003-01-21 CA CA002474852A patent/CA2474852A1/en not_active Abandoned
- 2003-01-21 EP EP20030734608 patent/EP1469857A1/en not_active Withdrawn
- 2003-01-24 TW TW092101618A patent/TW200302105A/zh unknown
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| JP2005523263A (ja) | 2005-08-04 |
| BR0307410A (pt) | 2004-12-28 |
| MXPA04007430A (es) | 2005-06-20 |
| GB0202254D0 (en) | 2002-03-20 |
| EP1469857A1 (en) | 2004-10-27 |
| WO2003063875A1 (en) | 2003-08-07 |
| TW200302105A (en) | 2003-08-01 |
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