CA2474156A1 - Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) - Google Patents
Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) Download PDFInfo
- Publication number
- CA2474156A1 CA2474156A1 CA002474156A CA2474156A CA2474156A1 CA 2474156 A1 CA2474156 A1 CA 2474156A1 CA 002474156 A CA002474156 A CA 002474156A CA 2474156 A CA2474156 A CA 2474156A CA 2474156 A1 CA2474156 A1 CA 2474156A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- cyclopentyl
- hydroxy
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des composés de la formule (I) ou un sel pharmaceutiquement acceptable desdits composés. Dans ladite formule, R?1¿ est hydroxy ou NHSO¿2?R?1A¿ (R?1A¿ étant alkyle (C¿1-8?), cycloalkyle (C¿3-7?) ou {alkyle (C¿1-6?)-cycloalkyle (C¿3-7?)}, tous éventuellement substitués 1 à 3 fois par halo, cyano, nitro, O-alkyle ( C¿1-6?), amido, amino ou phényle; ou bien R?1A¿ est aryle C¿6? ou C¿10? éventuellement substitué 1 à 3 fois par halo, cyano, nitro, alkyle (C¿1-6?), O-alkyle ( C¿1-6?), amido, amino ou phényle); R?2¿ est cycloalkyle (C¿4-6?); R?3¿ est t-btuyle ou cycloalkyle (C¿5-6?); et R?4¿ est cycloalkyle (C¿4-6?). Les composés de l'invention sont utiles comme inhibiteurs de la protéase NS3 du VHC destinés au traitement de l'hépatite C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2474156A CA2474156C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2,370,396 | 2002-02-01 | ||
CA002370396A CA2370396A1 (fr) | 2002-02-01 | 2002-02-01 | Tri-peptides inhibiteur de l'hepatite c |
PCT/CA2003/000090 WO2003064456A1 (fr) | 2002-02-01 | 2003-01-24 | Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) |
CA2474156A CA2474156C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2474156A1 true CA2474156A1 (fr) | 2003-08-07 |
CA2474156C CA2474156C (fr) | 2011-09-20 |
Family
ID=32991607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2474156A Expired - Fee Related CA2474156C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides comprenant un hydroxyproline ether d'une quinoline substituee destines a inhiber ns3 (hepatite c) |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2474156C (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007009227A1 (fr) * | 2005-07-20 | 2007-01-25 | Boehringer Ingelheim International Gmbh | Analogues de peptides inhibiteurs de l'hepatite c |
US7939667B2 (en) | 2003-05-21 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
-
2003
- 2003-01-24 CA CA2474156A patent/CA2474156C/fr not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939667B2 (en) | 2003-05-21 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
US8067438B2 (en) | 2003-05-21 | 2011-11-29 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
WO2007009227A1 (fr) * | 2005-07-20 | 2007-01-25 | Boehringer Ingelheim International Gmbh | Analogues de peptides inhibiteurs de l'hepatite c |
Also Published As
Publication number | Publication date |
---|---|
CA2474156C (fr) | 2011-09-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150126 |