CA2472633C - S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer - Google Patents

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Download PDF

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Publication number
CA2472633C
CA2472633C CA2472633A CA2472633A CA2472633C CA 2472633 C CA2472633 C CA 2472633C CA 2472633 A CA2472633 A CA 2472633A CA 2472633 A CA2472633 A CA 2472633A CA 2472633 C CA2472633 C CA 2472633C
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CA
Canada
Prior art keywords
cancer
cooh
compound
mer1
significant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2472633A
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English (en)
French (fr)
Other versions
CA2472633A1 (en
Inventor
Ralph A. Zingaro
Emil L. Freireich
Hatice Duzkale
Hagop Kantarjian
Srdan Verstovsek
Merida Sotelo-Lerma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Texas A&M University
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University of Texas System
Texas A&M University
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Application filed by University of Texas System, Texas A&M University filed Critical University of Texas System
Publication of CA2472633A1 publication Critical patent/CA2472633A1/en
Application granted granted Critical
Publication of CA2472633C publication Critical patent/CA2472633C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2472633A 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Expired - Fee Related CA2472633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34649202P 2002-01-07 2002-01-07
US60/346,492 2002-01-07
PCT/US2003/000281 WO2003057012A2 (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Publications (2)

Publication Number Publication Date
CA2472633A1 CA2472633A1 (en) 2003-07-17
CA2472633C true CA2472633C (en) 2014-07-08

Family

ID=23359639

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2472633A Expired - Fee Related CA2472633C (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Country Status (6)

Country Link
US (4) US6911471B2 (enExample)
EP (3) EP2462932A1 (enExample)
JP (4) JP4571408B2 (enExample)
AU (1) AU2003207455B2 (enExample)
CA (1) CA2472633C (enExample)
WO (1) WO2003057012A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2462932A1 (en) * 2002-01-07 2012-06-13 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
AU2011204901B2 (en) * 2004-07-16 2013-09-12 Board Of Regents, The University Of Texas System Compounds and methods for treatment of cancer
TW201350113A (zh) * 2004-07-16 2013-12-16 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
AU2006285329B2 (en) * 2005-07-29 2012-10-04 Solasia Pharma K.K. Compounds and methods for the treatment of cancer
KR20130129316A (ko) * 2006-01-13 2013-11-27 더 텍사스 에이 & 엠 유니버시티 시스템 암의 치료를 위한 화합물 및 방법
TW200829261A (en) * 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
WO2008052279A1 (en) * 2006-11-01 2008-05-08 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof
CA2704395A1 (en) * 2007-11-02 2009-05-14 Ziopharm Oncology, Inc. Combination therapy with organic arsenicals
AU2008335705A1 (en) * 2007-12-12 2009-06-18 Solasia Pharma K.K. Compounds and methods for the treatment of cancer
CA2724512A1 (en) * 2008-05-28 2009-12-23 Bennard Van Ravenzwaay Means and methods for assessing liver enzyme induction
MX2011001800A (es) 2008-08-20 2011-04-04 Ziopharm Oncology Inc Compuestos de arsenico organico y metodos para el tratamiento de cancer.
US8268807B2 (en) * 2010-04-19 2012-09-18 Sri International Compositions and method for the treatment of multiple myeloma
WO2015085208A1 (en) * 2013-12-05 2015-06-11 Solasia Pharma K.K. Compounds and methods for the treatment of cancer
CN112941027B (zh) * 2021-03-19 2021-11-02 苏州大学 二甲基亚胂酸致人角质形成细胞恶性转化细胞株及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2349729A (en) * 1940-08-24 1944-05-23 Parke Davis & Co Therapeutic arsenic preparation
US2701812A (en) * 1951-06-26 1955-02-08 Dainippon Pharmaceutical Co Diarylarsenious acid derivatives and the preparation thereof
DE3229565A1 (de) * 1982-08-07 1984-02-16 Etschenberg, Eugen, Dr., 5000 Köln Arsenhaltige nucleoside
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
AU751932B2 (en) * 1997-10-15 2002-08-29 Polarx Biopharmaceuticals, Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
PL343868A1 (en) 1997-11-10 2001-09-10 Sloan Kettering Inst Cancer Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
CN1233476A (zh) 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
DE60118172T2 (de) * 2000-04-26 2007-03-08 Oregon Health Sciences University, Portland Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält
AUPR379801A0 (en) 2001-03-19 2001-04-12 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en) 2001-06-28 2001-07-19 Unisearch Limited Inhibition of angiogenesis by targeting protein tyrosine phosphatases
CA2417008A1 (en) 2001-07-06 2003-01-16 Cochlear Limited Configuration of implanted devices
EP2462932A1 (en) * 2002-01-07 2012-06-13 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
US20060166208A1 (en) 2002-11-07 2006-07-27 Hogg Philip J Induction of the mitochondrial permeability transition
TW201350113A (zh) 2004-07-16 2013-12-16 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
WO2008052279A1 (en) 2006-11-01 2008-05-08 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof

Also Published As

Publication number Publication date
EP1474128A2 (en) 2004-11-10
AU2003207455A1 (en) 2003-07-24
JP2010090149A (ja) 2010-04-22
JP2015120745A (ja) 2015-07-02
EP1474128A4 (en) 2006-05-03
US20050131062A1 (en) 2005-06-16
CA2472633A1 (en) 2003-07-17
US6995188B2 (en) 2006-02-07
US6911471B2 (en) 2005-06-28
WO2003057012A2 (en) 2003-07-17
WO2003057012A8 (en) 2004-04-01
US20040034095A1 (en) 2004-02-19
US20080090904A1 (en) 2008-04-17
WO2003057012A3 (en) 2004-07-08
JP2005527487A (ja) 2005-09-15
JP4571408B2 (ja) 2010-10-27
EP1474128B1 (en) 2016-06-01
US7619000B2 (en) 2009-11-17
JP5603593B2 (ja) 2014-10-08
US20060189687A1 (en) 2006-08-24
AU2003207455A2 (en) 2003-07-24
AU2003207455B2 (en) 2007-09-20
JP2013237701A (ja) 2013-11-28
EP2462932A1 (en) 2012-06-13
EP2420229A1 (en) 2012-02-22

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Zingaro et al. S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

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