CA2472633C - S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer - Google Patents

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Download PDF

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Publication number
CA2472633C
CA2472633C CA2472633A CA2472633A CA2472633C CA 2472633 C CA2472633 C CA 2472633C CA 2472633 A CA2472633 A CA 2472633A CA 2472633 A CA2472633 A CA 2472633A CA 2472633 C CA2472633 C CA 2472633C
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CA
Canada
Prior art keywords
cancer
cooh
compound
mer1
significant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2472633A
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English (en)
French (fr)
Other versions
CA2472633A1 (en
Inventor
Ralph A. Zingaro
Emil L. Freireich
Hatice Duzkale
Hagop Kantarjian
Srdan Verstovsek
Merida Sotelo-Lerma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Texas A&M University
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University of Texas System
Texas A&M University
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Application filed by University of Texas System, Texas A&M University filed Critical University of Texas System
Publication of CA2472633A1 publication Critical patent/CA2472633A1/en
Application granted granted Critical
Publication of CA2472633C publication Critical patent/CA2472633C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2472633A 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Expired - Fee Related CA2472633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34649202P 2002-01-07 2002-01-07
US60/346,492 2002-01-07
PCT/US2003/000281 WO2003057012A2 (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Publications (2)

Publication Number Publication Date
CA2472633A1 CA2472633A1 (en) 2003-07-17
CA2472633C true CA2472633C (en) 2014-07-08

Family

ID=23359639

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2472633A Expired - Fee Related CA2472633C (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Country Status (6)

Country Link
US (4) US6911471B2 (enExample)
EP (3) EP2462932A1 (enExample)
JP (4) JP4571408B2 (enExample)
AU (1) AU2003207455B2 (enExample)
CA (1) CA2472633C (enExample)
WO (1) WO2003057012A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2462932A1 (en) * 2002-01-07 2012-06-13 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
AU2011204901B2 (en) * 2004-07-16 2013-09-12 Board Of Regents, The University Of Texas System Compounds and methods for treatment of cancer
TW201440760A (zh) * 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
ES2532666T3 (es) 2005-07-29 2015-03-30 Solasia Pharma K.K. Compuestos y métodos para el tratamiento del cáncer
CN104109177A (zh) * 2006-01-13 2014-10-22 得克萨斯州A&M大学系统 用于治疗癌症的化合物和方法
TW200829261A (en) 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
CA2668010C (en) * 2006-11-01 2015-03-24 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof
KR20100100835A (ko) 2007-11-02 2010-09-15 지오팜 온콜로지 인코포레이티드 유기 비소제와의 병용 요법
CN104592302A (zh) * 2007-12-12 2015-05-06 日本苏爱康制药有限公司 用于治疗癌症的化合物和方法
AU2009259535B2 (en) * 2008-05-28 2016-01-21 Basf Se Means and methods for assessing liver enzyme induction
RU2534606C2 (ru) 2008-08-20 2014-11-27 Зайофарм Онколоджи, Инк. Мышьякорганические соединения и способы лечения рака
WO2011133475A2 (en) * 2010-04-19 2011-10-27 Sri International Compositions and method for the treatment of multiple myeloma
TWI617305B (zh) * 2013-12-05 2018-03-11 蘇愛康制藥有限公司 治療癌症的化合物及其應用程序
CN112941027B (zh) * 2021-03-19 2021-11-02 苏州大学 二甲基亚胂酸致人角质形成细胞恶性转化细胞株及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2349729A (en) * 1940-08-24 1944-05-23 Parke Davis & Co Therapeutic arsenic preparation
US2701812A (en) * 1951-06-26 1955-02-08 Dainippon Pharmaceutical Co Diarylarsenious acid derivatives and the preparation thereof
DE3229565A1 (de) * 1982-08-07 1984-02-16 Etschenberg, Eugen, Dr., 5000 Köln Arsenhaltige nucleoside
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
WO1999018798A1 (en) 1997-10-15 1999-04-22 Polarx Biopharmaceuticals, Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
IL136051A0 (en) * 1997-11-10 2001-05-20 Sloan Kettering Inst Cancer Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
CN1233476A (zh) 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
CN1443064A (zh) 2000-04-26 2003-09-17 俄勒冈健康科学大学 施用含硫醇化学保护化合物的方法
AUPR379801A0 (en) 2001-03-19 2001-04-12 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en) 2001-06-28 2001-07-19 Unisearch Limited Inhibition of angiogenesis by targeting protein tyrosine phosphatases
DE60140318D1 (de) 2001-07-06 2009-12-10 Cochlear Ltd Konfiguration implantierter vorrichtungen
EP2462932A1 (en) 2002-01-07 2012-06-13 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
US20060166208A1 (en) 2002-11-07 2006-07-27 Hogg Philip J Induction of the mitochondrial permeability transition
TW201440760A (zh) 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
CA2668010C (en) 2006-11-01 2015-03-24 Newsouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof

Also Published As

Publication number Publication date
JP4571408B2 (ja) 2010-10-27
AU2003207455B2 (en) 2007-09-20
EP2420229A1 (en) 2012-02-22
US20060189687A1 (en) 2006-08-24
EP1474128A2 (en) 2004-11-10
JP2010090149A (ja) 2010-04-22
US6911471B2 (en) 2005-06-28
US20080090904A1 (en) 2008-04-17
WO2003057012A2 (en) 2003-07-17
US7619000B2 (en) 2009-11-17
US20050131062A1 (en) 2005-06-16
JP2005527487A (ja) 2005-09-15
JP2013237701A (ja) 2013-11-28
EP1474128B1 (en) 2016-06-01
JP2015120745A (ja) 2015-07-02
US20040034095A1 (en) 2004-02-19
CA2472633A1 (en) 2003-07-17
AU2003207455A1 (en) 2003-07-24
EP2462932A1 (en) 2012-06-13
WO2003057012A3 (en) 2004-07-08
EP1474128A4 (en) 2006-05-03
US6995188B2 (en) 2006-02-07
JP5603593B2 (ja) 2014-10-08
AU2003207455A2 (en) 2003-07-24
WO2003057012A8 (en) 2004-04-01

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US20080090904A1 (en) S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
US20080090793A1 (en) Compounds and methods for the treatment of cancer
AU2007249110B2 (en) S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatment for cancer
HK1166959A (en) S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
HK1171952A (en) S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
AU2011204901B2 (en) Compounds and methods for treatment of cancer
Zingaro et al. S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
Lerma et al. S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

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