CA2472377A1 - Crystalline solids of carvedilol and processes for their preparation - Google Patents

Crystalline solids of carvedilol and processes for their preparation Download PDF

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Publication number
CA2472377A1
CA2472377A1 CA002472377A CA2472377A CA2472377A1 CA 2472377 A1 CA2472377 A1 CA 2472377A1 CA 002472377 A CA002472377 A CA 002472377A CA 2472377 A CA2472377 A CA 2472377A CA 2472377 A1 CA2472377 A1 CA 2472377A1
Authority
CA
Canada
Prior art keywords
carvedilol
crystalline
peaks
dosage form
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002472377A
Other languages
English (en)
French (fr)
Inventor
Ilan Kor
Shlomit Wizel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23371828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2472377(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2472377A1 publication Critical patent/CA2472377A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
CA002472377A 2002-01-15 2003-01-15 Crystalline solids of carvedilol and processes for their preparation Abandoned CA2472377A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34931002P 2002-01-15 2002-01-15
US60/349,310 2002-01-15
PCT/US2003/001137 WO2003059807A2 (en) 2002-01-15 2003-01-15 Crystalline solids of carvedilol and processes for their preparation

Publications (1)

Publication Number Publication Date
CA2472377A1 true CA2472377A1 (en) 2003-07-24

Family

ID=23371828

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002472377A Abandoned CA2472377A1 (en) 2002-01-15 2003-01-15 Crystalline solids of carvedilol and processes for their preparation

Country Status (14)

Country Link
US (3) US6710184B2 (US20030166702A1-20030904-C00001.png)
EP (1) EP1474133A4 (US20030166702A1-20030904-C00001.png)
JP (1) JP2005515226A (US20030166702A1-20030904-C00001.png)
KR (1) KR20040077872A (US20030166702A1-20030904-C00001.png)
CN (1) CN1298322C (US20030166702A1-20030904-C00001.png)
AU (1) AU2003205146A1 (US20030166702A1-20030904-C00001.png)
CA (1) CA2472377A1 (US20030166702A1-20030904-C00001.png)
HR (1) HRP20040673A2 (US20030166702A1-20030904-C00001.png)
IS (1) IS7351A (US20030166702A1-20030904-C00001.png)
MX (1) MXPA04006909A (US20030166702A1-20030904-C00001.png)
NO (1) NO20043383L (US20030166702A1-20030904-C00001.png)
PL (1) PL371409A1 (US20030166702A1-20030904-C00001.png)
WO (1) WO2003059807A2 (US20030166702A1-20030904-C00001.png)
ZA (1) ZA200405443B (US20030166702A1-20030904-C00001.png)

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US6389455B1 (en) * 1998-09-22 2002-05-14 Richard C. Fuisz Method and apparatus for bouncing electronic messages
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
WO2002000216A1 (en) 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
US7122376B2 (en) * 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7049146B2 (en) 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US6710184B2 (en) 2002-01-15 2004-03-23 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
EP1499310A4 (en) * 2002-04-30 2005-12-07 Sb Pharmco Inc MONOCITRATE MONOHYDRATE OF CARVEDILOL
JP2005533823A (ja) * 2002-06-27 2005-11-10 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド リン酸カルベジロール塩および／またはその溶媒和物、対応する組成物、および／または治療方法
WO2004002472A1 (en) * 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Carvedilol hydrobromide
US20040152756A1 (en) * 2002-07-15 2004-08-05 Wei Chen Carvedilol polymorph
WO2004094378A1 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
US20050042182A1 (en) * 2003-08-13 2005-02-24 Moshe Arkin Topical compositions of urea
US20050037040A1 (en) * 2003-08-13 2005-02-17 Moshe Arkin Topical compositions of urea and ammonium lactate
US20050036953A1 (en) * 2003-08-13 2005-02-17 Moshe Arkin Topical compositions of ammonium lactate
US20050042268A1 (en) * 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
US20050069499A1 (en) * 2003-09-25 2005-03-31 Moshe Arkin Foamable compositions, processes of preparing same and uses thereof
EP1686986A4 (en) * 2003-11-25 2009-05-27 Sb Pharmco Inc CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT
EP1686967A4 (en) * 2003-11-25 2012-08-08 Smithkline Beecham Cork Ltd CARVEDILOL-FREE BASE, SALTS, WATER-FREE FORMS OR SOLVATES THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULAS AND TREATMENT OR DISPOSAL PROCEDURES
US20060057075A1 (en) * 2004-08-02 2006-03-16 Moshe Arkin Pharmaceutical and cosmeceutical wash-off mousse shampoo compositions, processes for preparing the same and uses thereof
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
WO2007043938A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab NOVEL CRYSTALLINE FORM OF 3,5-DIBROMO-N- [ (2S) -2- (-4- FLUOROPHENYL) -4- (3-MORPHOLIN-4-YLAZTIDIN-l-YL) BUTYL] -N METHYLBENZAMIDE, MODIFICATION B
WO2007077111A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
US8022094B2 (en) 2006-06-28 2011-09-20 Teva Pharmaceutical Industries Ltd. Carvedilol phosphate
GB2442238B (en) * 2006-09-29 2008-10-01 Rolls Royce Plc Sheet metal blank
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
CA2705884A1 (en) * 2007-11-14 2009-05-22 Manuel Gidekel New extracts of deschampsia antarctica desv. with antineoplastic activity
WO2015031914A1 (en) * 2013-08-30 2015-03-05 Uti Limited Partnership Store overload-induced calcium release inhibitors and methods for producing and using the same
PE20160945A1 (es) 2013-11-15 2016-09-26 Akebia Therapeutics Inc Formas solidas de acido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acetico, composiciones, y usos de las mismas

Family Cites Families (28)

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DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
FR2725623A1 (fr) 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US6730326B2 (en) 1997-07-22 2004-05-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it
EP0893440A1 (en) * 1997-07-22 1999-01-27 Roche Diagnostics GmbH Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
HU227441B1 (en) * 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof
DE19954569A1 (de) 1999-11-12 2001-05-17 Schwabe Willmar Gmbh & Co Pharmakologisch aktive Tetrahydrothiopyran-4-ol-Derivate, Verfahren zu ihrer Herstellung und Verwendung
WO2002000216A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
JP4056883B2 (ja) 2001-01-25 2008-03-05 エフ．ホフマン−ラ ロシュ アーゲー ヘテロ環式インデン類似体の調製方法
DE60212130D1 (en) * 2001-07-13 2006-07-20 Smithkline Beecham Corp Carvedilolpolymorph
JP2005507899A (ja) 2001-09-28 2005-03-24 エフ．ホフマン−ラ　ロシュ　アーゲー カルベジロールの疑似多形形態
US6710184B2 (en) 2002-01-15 2004-03-23 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
JP2005533823A (ja) 2002-06-27 2005-11-10 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド リン酸カルベジロール塩および／またはその溶媒和物、対応する組成物、および／または治療方法
US20040152756A1 (en) * 2002-07-15 2004-08-05 Wei Chen Carvedilol polymorph
SK285547B6 (sk) 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
WO2004094378A1 (en) 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of carvedilol form-ii
WO2004113296A1 (en) 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
SI21616A (sl) 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
EP1686986A4 (en) 2003-11-25 2009-05-27 Sb Pharmco Inc CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT
CA2560353A1 (en) 2004-02-23 2005-09-01 Cadila Healthcare Limited Process for manufacture of racemic carvedilol
US20070191456A1 (en) 2004-04-22 2007-08-16 Tarur Venkatasubramanian R Novel process for the preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(-methoxyphenoxy)-ethyl] amino]-propan-2-ol
GB0411273D0 (en) 2004-05-20 2004-06-23 Cipla Ltd Process and product
WO2006061364A1 (en) 2004-12-09 2006-06-15 Zach System S.P.A. Process for the preparation of carvedilol and its enantiomers
US20070027202A1 (en) 2005-06-07 2007-02-01 Ashok Kumar Process for the preparation of carvedilol and its salts
WO2007057316A2 (en) 2005-11-16 2007-05-24 F. Hoffmann-La Roche Ag Novel process for the preparation of thoc
WO2007077111A1 (en) 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
KR100746455B1 (ko) 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법

Also Published As

Publication number Publication date
CN1615133A (zh) 2005-05-11
IS7351A (is) 2004-07-13
US7598396B2 (en) 2009-10-06
JP2005515226A (ja) 2005-05-26
US20090163721A1 (en) 2009-06-25
US20030166702A1 (en) 2003-09-04
EP1474133A2 (en) 2004-11-10
US20040171665A1 (en) 2004-09-02
CN1298322C (zh) 2007-02-07
US7514467B2 (en) 2009-04-07
EP1474133A4 (en) 2006-02-01
HRP20040673A2 (en) 2005-06-30
AU2003205146A1 (en) 2003-07-30
MXPA04006909A (es) 2005-04-19
WO2003059807A2 (en) 2003-07-24
PL371409A1 (en) 2005-06-13
WO2003059807A3 (en) 2003-12-04
ZA200405443B (en) 2005-07-08
NO20043383L (no) 2004-08-13
US6710184B2 (en) 2004-03-23
KR20040077872A (ko) 2004-09-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued