CA2470111A1 - Production of chirally pure .alpha.-amino acids and n-sulfonyl .alpha.-amino acids - Google Patents
Production of chirally pure .alpha.-amino acids and n-sulfonyl .alpha.-amino acids Download PDFInfo
- Publication number
- CA2470111A1 CA2470111A1 CA002470111A CA2470111A CA2470111A1 CA 2470111 A1 CA2470111 A1 CA 2470111A1 CA 002470111 A CA002470111 A CA 002470111A CA 2470111 A CA2470111 A CA 2470111A CA 2470111 A1 CA2470111 A1 CA 2470111A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- sulfonyl
- alpha
- amino acid
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/014,304 | 2001-12-11 | ||
US10/014,304 US6610734B2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US10/166,896 US6657070B2 (en) | 2000-12-13 | 2002-06-11 | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
US10/166,896 | 2002-06-11 | ||
PCT/US2002/038117 WO2003050062A2 (en) | 2001-12-11 | 2002-11-26 | PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2470111A1 true CA2470111A1 (en) | 2003-06-19 |
Family
ID=46204648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002470111A Abandoned CA2470111A1 (en) | 2001-12-11 | 2002-11-26 | Production of chirally pure .alpha.-amino acids and n-sulfonyl .alpha.-amino acids |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1461332A4 (ja) |
JP (1) | JP4615861B2 (ja) |
AU (2) | AU2002351170B8 (ja) |
CA (1) | CA2470111A1 (ja) |
MX (1) | MXPA04005366A (ja) |
TW (1) | TWI260316B (ja) |
WO (1) | WO2003050062A2 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2436526C (en) | 2000-12-13 | 2010-10-19 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
NZ542468A (en) | 2003-03-31 | 2009-01-31 | Wyeth Corp | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
CN1910158A (zh) | 2004-01-16 | 2007-02-07 | 惠氏公司 | 含有氮杂环的β淀粉样蛋白生成的杂环磺酰胺抑制剂 |
JP2009534385A (ja) | 2006-04-21 | 2009-09-24 | ワイス | キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3802981A1 (de) * | 1988-02-02 | 1989-08-10 | Basf Ag | Verfahren zur reduktion reduzierbarer verbindungen |
US5264577A (en) * | 1992-04-22 | 1993-11-23 | Warner-Lambert Company | Cyclic amino acids and derivatives thereof |
US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US6191306B1 (en) * | 1999-08-03 | 2001-02-20 | Eastman Chemical Company | Process for the preparation of cyclopropylglycine |
-
2002
- 2002-11-26 WO PCT/US2002/038117 patent/WO2003050062A2/en active Application Filing
- 2002-11-26 EP EP02786817A patent/EP1461332A4/en not_active Withdrawn
- 2002-11-26 MX MXPA04005366A patent/MXPA04005366A/es active IP Right Grant
- 2002-11-26 AU AU2002351170A patent/AU2002351170B8/en not_active Ceased
- 2002-11-26 JP JP2003551090A patent/JP4615861B2/ja not_active Expired - Fee Related
- 2002-11-26 CA CA002470111A patent/CA2470111A1/en not_active Abandoned
- 2002-12-10 TW TW091135621A patent/TWI260316B/zh active
-
2009
- 2009-12-24 AU AU2009251195A patent/AU2009251195A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2009251195A1 (en) | 2010-01-21 |
JP4615861B2 (ja) | 2011-01-19 |
EP1461332A4 (en) | 2009-10-21 |
AU2002351170B2 (en) | 2009-09-24 |
WO2003050062A3 (en) | 2003-11-20 |
EP1461332A2 (en) | 2004-09-29 |
AU2002351170A1 (en) | 2003-06-23 |
WO2003050062A2 (en) | 2003-06-19 |
MXPA04005366A (es) | 2004-09-27 |
TW200306292A (en) | 2003-11-16 |
AU2002351170B8 (en) | 2009-10-08 |
TWI260316B (en) | 2006-08-21 |
JP2005511727A (ja) | 2005-04-28 |
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Publication | Publication Date | Title |
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US6610734B2 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
US7858658B2 (en) | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | |
AU2002245123A1 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
US6657070B2 (en) | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids | |
BRPI0707741A2 (pt) | mÉtodos para preparar um amino Álcool, ou sal do mesmo, e um Álcool substituÍdo por sulfonamida | |
US7598422B2 (en) | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof | |
AU2009251195A1 (en) | Production of chirally pure alpha-amino acids and n-sulfonyl alpha-amino acids | |
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US20180230122A1 (en) | Production method for heteroarylcarboxylic acid ester derivative, production intermediate thereof, and crystal | |
JP5410677B2 (ja) | 光学活性アミノペンタン誘導体の製造方法、および中間体とその製造方法 | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |