CA2466017C - Microcoil vaso-occlusive device with multi-axis secondary configuration - Google Patents
Microcoil vaso-occlusive device with multi-axis secondary configuration Download PDFInfo
- Publication number
- CA2466017C CA2466017C CA002466017A CA2466017A CA2466017C CA 2466017 C CA2466017 C CA 2466017C CA 002466017 A CA002466017 A CA 002466017A CA 2466017 A CA2466017 A CA 2466017A CA 2466017 C CA2466017 C CA 2466017C
- Authority
- CA
- Canada
- Prior art keywords
- energy state
- microcoil
- minimum energy
- configuration
- aneurysm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010002329 Aneurysm Diseases 0.000 claims abstract description 59
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 4
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims 2
- 230000002792 vascular Effects 0.000 abstract description 16
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- 238000004804 winding Methods 0.000 description 14
- 239000000463 material Substances 0.000 description 13
- 230000010102 embolization Effects 0.000 description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
- 210000003739 neck Anatomy 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 7
- 210000001367 artery Anatomy 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 229910052697 platinum Inorganic materials 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000005056 compaction Methods 0.000 description 4
- 230000003073 embolic effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- 229910000990 Ni alloy Inorganic materials 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011819 refractory material Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 201000008450 Intracranial aneurysm Diseases 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 229910001080 W alloy Inorganic materials 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- WMWLMWRWZQELOS-UHFFFAOYSA-N bismuth(III) oxide Inorganic materials O=[Bi]O[Bi]=O WMWLMWRWZQELOS-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 210000004720 cerebrum Anatomy 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- BABWHSBPEIVBBZ-UHFFFAOYSA-N diazete Chemical compound C1=CN=N1 BABWHSBPEIVBBZ-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- QRWOVIRDHQJFDB-UHFFFAOYSA-N isobutyl cyanoacrylate Chemical compound CC(C)COC(=O)C(=C)C#N QRWOVIRDHQJFDB-UHFFFAOYSA-N 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/050970 WO2003039376A1 (en) | 2001-11-07 | 2001-11-07 | Microcoil vaso-occlusive device with multi-axis secondary configuration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2466017A1 CA2466017A1 (en) | 2003-05-15 |
| CA2466017C true CA2466017C (en) | 2008-10-28 |
Family
ID=21743179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466017A Expired - Fee Related CA2466017C (en) | 2001-11-07 | 2001-11-07 | Microcoil vaso-occlusive device with multi-axis secondary configuration |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1448105B1 (enExample) |
| JP (1) | JP4109627B2 (enExample) |
| CN (1) | CN1558741A (enExample) |
| AT (1) | ATE452585T1 (enExample) |
| AU (1) | AU2002236676B2 (enExample) |
| BR (1) | BR0117168A (enExample) |
| CA (1) | CA2466017C (enExample) |
| DE (1) | DE60140905D1 (enExample) |
| ES (1) | ES2338635T3 (enExample) |
| WO (1) | WO2003039376A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7029486B2 (en) | 2000-09-26 | 2006-04-18 | Microvention, Inc. | Microcoil vaso-occlusive device with multi-axis secondary configuration |
| CN100448412C (zh) * | 2006-04-29 | 2009-01-07 | 朱国华 | 一种手术钛夹的制作方法 |
| US20090254112A1 (en) * | 2007-02-07 | 2009-10-08 | Micrus Endovascular Corporation | Winding mandrel for vasoocclusive coils |
| JP5227344B2 (ja) * | 2007-03-13 | 2013-07-03 | タイコ ヘルスケア グループ リミテッド パートナーシップ | インプラント、マンドレル、およびインプラント形成方法 |
| US8034075B2 (en) * | 2007-11-09 | 2011-10-11 | Micrus Endovascular Corporation | Tethered coil for treatment of body lumens |
| JP5754736B2 (ja) * | 2008-08-06 | 2015-07-29 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | テクスチャ表面を有する血管閉塞装置 |
| EP3110343B1 (en) | 2014-02-27 | 2018-10-31 | Incumedx Inc. | Embolic framing microcoils |
| US10307168B2 (en) | 2015-08-07 | 2019-06-04 | Terumo Corporation | Complex coil and manufacturing techniques |
| JP6147382B1 (ja) * | 2016-03-07 | 2017-06-14 | 田中貴金属工業株式会社 | 塞栓用コイル及び塞栓用コイルの製造方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US427680A (en) | 1890-05-13 | good-son | ||
| HU184722B (en) | 1980-02-18 | 1984-10-29 | Laszlo Lazar | Therapeutically suitable silicone rubber mixture and therapeuticaid |
| US4795741A (en) | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
| US4819637A (en) | 1987-09-01 | 1989-04-11 | Interventional Therapeutics Corporation | System for artificial vessel embolization and devices for use therewith |
| US4994069A (en) | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
| US5122136A (en) | 1990-03-13 | 1992-06-16 | The Regents Of The University Of California | Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
| US5108407A (en) | 1990-06-08 | 1992-04-28 | Rush-Presbyterian St. Luke's Medical Center | Method and apparatus for placement of an embolic coil |
| US5133731A (en) | 1990-11-09 | 1992-07-28 | Catheter Research, Inc. | Embolus supply system and method |
| US5226911A (en) | 1991-10-02 | 1993-07-13 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
| US5304194A (en) | 1991-10-02 | 1994-04-19 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
| US5261916A (en) | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
| ATE187053T1 (de) | 1991-12-12 | 1999-12-15 | Target Therapeutics Inc | Entkuppelbare, verschiebbare, gefässverschliessende spirale mit ineinandergreifenden kupplungselementen |
| US5234437A (en) | 1991-12-12 | 1993-08-10 | Target Therapeutics, Inc. | Detachable pusher-vasoocclusion coil assembly with threaded coupling |
| US5312415A (en) | 1992-09-22 | 1994-05-17 | Target Therapeutics, Inc. | Assembly for placement of embolic coils using frictional placement |
| US5382259A (en) | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
| US5382260A (en) | 1992-10-30 | 1995-01-17 | Interventional Therapeutics Corp. | Embolization device and apparatus including an introducer cartridge and method for delivering the same |
| US5690666A (en) | 1992-11-18 | 1997-11-25 | Target Therapeutics, Inc. | Ultrasoft embolism coils and process for using them |
| AU681073B2 (en) * | 1992-11-19 | 1997-08-21 | Target Therapeutics, Inc. | Large diameter vasoocclusion coil |
| US5800453A (en) | 1993-04-19 | 1998-09-01 | Target Therapeutics, Inc. | Detachable embolic coil assembly using interlocking hooks and slots |
| US5423829A (en) | 1993-11-03 | 1995-06-13 | Target Therapeutics, Inc. | Electrolytically severable joint for endovascular embolic devices |
| JP2535785B2 (ja) | 1994-06-03 | 1996-09-18 | 工業技術院長 | 血管塞栓剤 |
| US5549624A (en) | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
| US5725546A (en) | 1994-06-24 | 1998-03-10 | Target Therapeutics, Inc. | Detachable microcoil delivery catheter |
| US5522836A (en) | 1994-06-27 | 1996-06-04 | Target Therapeutics, Inc. | Electrolytically severable coil assembly with movable detachment point |
| US5690671A (en) | 1994-12-13 | 1997-11-25 | Micro Interventional Systems, Inc. | Embolic elements and methods and apparatus for their delivery |
| US5578074A (en) | 1994-12-22 | 1996-11-26 | Target Therapeutics, Inc. | Implant delivery method and assembly |
| US5814062A (en) | 1994-12-22 | 1998-09-29 | Target Therapeutics, Inc. | Implant delivery assembly with expandable coupling/decoupling mechanism |
| US5645558A (en) | 1995-04-20 | 1997-07-08 | Medical University Of South Carolina | Anatomically shaped vasoocclusive device and method of making the same |
| US5911731A (en) | 1995-04-20 | 1999-06-15 | Target Therapeutics, Inc. | Anatomically shaped vasoocclusive devices |
| US5639277A (en) | 1995-04-28 | 1997-06-17 | Target Therapeutics, Inc. | Embolic coils with offset helical and twisted helical shapes |
| US5645564A (en) | 1995-05-22 | 1997-07-08 | Regents Of The University Of California | Microfabricated therapeutic actuator mechanisms |
| US5624461A (en) | 1995-06-06 | 1997-04-29 | Target Therapeutics, Inc. | Three dimensional in-filling vaso-occlusive coils |
| WO1997001368A1 (en) | 1995-06-26 | 1997-01-16 | Trimedyne, Inc. | Therapeutic appliance releasing device |
| US5582619A (en) | 1995-06-30 | 1996-12-10 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils |
| US6013084A (en) | 1995-06-30 | 2000-01-11 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
| US5580568A (en) | 1995-07-27 | 1996-12-03 | Micro Therapeutics, Inc. | Cellulose diacetate compositions for use in embolizing blood vessels |
| US5658308A (en) | 1995-12-04 | 1997-08-19 | Target Therapeutics, Inc. | Bioactive occlusion coil |
| JP3784112B2 (ja) | 1996-08-15 | 2006-06-07 | 株式会社カネカメディックス | コイル状塞栓物質 |
| US5690667A (en) | 1996-09-26 | 1997-11-25 | Target Therapeutics | Vasoocclusion coil having a polymer tip |
| US5911737A (en) | 1997-02-28 | 1999-06-15 | The Regents Of The University Of California | Microfabricated therapeutic actuators |
| US6322576B1 (en) * | 1997-08-29 | 2001-11-27 | Target Therapeutics, Inc. | Stable coil designs |
| US6022369A (en) | 1998-02-13 | 2000-02-08 | Precision Vascular Systems, Inc. | Wire device with detachable end |
| US6068644A (en) | 1998-03-10 | 2000-05-30 | Cordis Corporation | Embolic coil hydraulic deployment system having improved catheter |
| US6063100A (en) | 1998-03-10 | 2000-05-16 | Cordis Corporation | Embolic coil deployment system with improved embolic coil |
| US6015424A (en) | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
| US6165194A (en) * | 1998-07-24 | 2000-12-26 | Micrus Corporation | Intravascular flow modifier and reinforcement device |
| US6551340B1 (en) * | 1998-10-09 | 2003-04-22 | Board Of Regents The University Of Texas System | Vasoocclusion coil device having a core therein |
| US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
| US6790218B2 (en) * | 1999-12-23 | 2004-09-14 | Swaminathan Jayaraman | Occlusive coil manufacture and delivery |
-
2001
- 2001-11-07 WO PCT/US2001/050970 patent/WO2003039376A1/en not_active Ceased
- 2001-11-07 JP JP2003541472A patent/JP4109627B2/ja not_active Expired - Fee Related
- 2001-11-07 EP EP01986219A patent/EP1448105B1/en not_active Expired - Lifetime
- 2001-11-07 BR BR0117168-2A patent/BR0117168A/pt not_active IP Right Cessation
- 2001-11-07 DE DE60140905T patent/DE60140905D1/de not_active Expired - Lifetime
- 2001-11-07 CN CNA018237738A patent/CN1558741A/zh active Pending
- 2001-11-07 AT AT01986219T patent/ATE452585T1/de not_active IP Right Cessation
- 2001-11-07 ES ES01986219T patent/ES2338635T3/es not_active Expired - Lifetime
- 2001-11-07 AU AU2002236676A patent/AU2002236676B2/en not_active Ceased
- 2001-11-07 CA CA002466017A patent/CA2466017C/en not_active Expired - Fee Related
- 2001-11-07 EP EP09015616.7A patent/EP2163212B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2338635T3 (es) | 2010-05-11 |
| EP2163212A1 (en) | 2010-03-17 |
| EP1448105B1 (en) | 2009-12-23 |
| DE60140905D1 (de) | 2010-02-04 |
| BR0117168A (pt) | 2004-10-26 |
| ATE452585T1 (de) | 2010-01-15 |
| CN1558741A (zh) | 2004-12-29 |
| EP1448105A1 (en) | 2004-08-25 |
| CA2466017A1 (en) | 2003-05-15 |
| JP2005507300A (ja) | 2005-03-17 |
| WO2003039376A1 (en) | 2003-05-15 |
| JP4109627B2 (ja) | 2008-07-02 |
| AU2002236676B2 (en) | 2008-02-28 |
| EP2163212B1 (en) | 2015-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20121107 |