CA2465746C - Hydrazono-malonitriles - Google Patents
Hydrazono-malonitriles Download PDFInfo
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- CA2465746C CA2465746C CA2465746A CA2465746A CA2465746C CA 2465746 C CA2465746 C CA 2465746C CA 2465746 A CA2465746 A CA 2465746A CA 2465746 A CA2465746 A CA 2465746A CA 2465746 C CA2465746 C CA 2465746C
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- NBRKLOOSMBRFMH-UHFFFAOYSA-N tert-butyl chloride Chemical class CC(C)(C)Cl NBRKLOOSMBRFMH-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- QZKRHPLGUJDVAR-UHFFFAOYSA-N trisodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O QZKRHPLGUJDVAR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P17/00—Drugs for dermatological disorders
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01125455.4 | 2001-11-05 | ||
| EP01125455 | 2001-11-05 | ||
| PCT/EP2002/011351 WO2003039548A1 (en) | 2001-11-05 | 2002-10-10 | Hydrazono-malonitriles |
Publications (2)
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| CA2465746A1 CA2465746A1 (en) | 2003-05-15 |
| CA2465746C true CA2465746C (en) | 2011-09-06 |
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|---|---|---|---|
| CA2465746A Expired - Fee Related CA2465746C (en) | 2001-11-05 | 2002-10-10 | Hydrazono-malonitriles |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7141572B2 (enExample) |
| EP (1) | EP1441730B1 (enExample) |
| JP (1) | JP5116940B2 (enExample) |
| KR (1) | KR100898894B1 (enExample) |
| CN (1) | CN1585641A (enExample) |
| AR (1) | AR040629A1 (enExample) |
| AT (1) | ATE335486T1 (enExample) |
| AU (1) | AU2002363368B2 (enExample) |
| BR (1) | BR0213683A (enExample) |
| CA (1) | CA2465746C (enExample) |
| DE (1) | DE60213841T2 (enExample) |
| ES (1) | ES2268157T3 (enExample) |
| HU (1) | HUP0401747A3 (enExample) |
| MX (1) | MXPA04004263A (enExample) |
| MY (1) | MY129491A (enExample) |
| PL (1) | PL369738A1 (enExample) |
| RU (1) | RU2302412C2 (enExample) |
| WO (1) | WO2003039548A1 (enExample) |
| ZA (1) | ZA200404387B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| JPWO2004087641A1 (ja) * | 2003-03-31 | 2006-06-29 | 第一製薬株式会社 | ヒドラゾン誘導体 |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| RS52944B (sr) * | 2005-04-19 | 2014-02-28 | Takeda Gmbh | Roflumilast za lečenje pulmonarne hipertenzije |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| CA2648036C (en) | 2006-03-31 | 2012-05-22 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| JP6063123B2 (ja) | 2008-11-15 | 2017-01-18 | メリンタ セラピューティクス、インク | 抗菌性組成物 |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| US8440655B2 (en) * | 2010-06-21 | 2013-05-14 | Theracos, Inc. | Combination therapy for the treatment of diabetes |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
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| EA201591360A1 (ru) | 2013-02-19 | 2016-03-31 | Пфайзер Инк. | Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств |
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| AU2015298378B2 (en) | 2014-08-06 | 2018-08-02 | Pfizer Inc. | Imidazopyridazine compounds |
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| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
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|---|---|---|---|---|
| GB8400863D0 (en) * | 1984-01-13 | 1984-02-15 | Smith Kline French Lab | Chemical compounds |
| DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19850701A1 (de) * | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
| DE19932315A1 (de) | 1999-07-10 | 2001-01-11 | Merck Patent Gmbh | Benzoylpyridazine |
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2002
- 2002-10-10 CA CA2465746A patent/CA2465746C/en not_active Expired - Fee Related
- 2002-10-10 KR KR1020047006820A patent/KR100898894B1/ko not_active Expired - Fee Related
- 2002-10-10 DE DE60213841T patent/DE60213841T2/de not_active Expired - Lifetime
- 2002-10-10 AT AT02802625T patent/ATE335486T1/de not_active IP Right Cessation
- 2002-10-10 BR BR0213683-0A patent/BR0213683A/pt not_active IP Right Cessation
- 2002-10-10 WO PCT/EP2002/011351 patent/WO2003039548A1/en not_active Ceased
- 2002-10-10 HU HU0401747A patent/HUP0401747A3/hu unknown
- 2002-10-10 ES ES02802625T patent/ES2268157T3/es not_active Expired - Lifetime
- 2002-10-10 AU AU2002363368A patent/AU2002363368B2/en not_active Ceased
- 2002-10-10 JP JP2003541839A patent/JP5116940B2/ja not_active Expired - Fee Related
- 2002-10-10 RU RU2004117171/04A patent/RU2302412C2/ru not_active IP Right Cessation
- 2002-10-10 US US10/494,631 patent/US7141572B2/en not_active Expired - Fee Related
- 2002-10-10 PL PL02369738A patent/PL369738A1/xx not_active Application Discontinuation
- 2002-10-10 CN CNA028222164A patent/CN1585641A/zh active Pending
- 2002-10-10 MX MXPA04004263A patent/MXPA04004263A/es active IP Right Grant
- 2002-10-10 EP EP02802625A patent/EP1441730B1/en not_active Expired - Lifetime
- 2002-11-01 AR AR20020104169A patent/AR040629A1/es unknown
- 2002-11-01 MY MYPI20024107A patent/MY129491A/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2465746A1 (en) | 2003-05-15 |
| RU2004117171A (ru) | 2006-01-10 |
| US7141572B2 (en) | 2006-11-28 |
| CN1585641A (zh) | 2005-02-23 |
| ZA200404387B (en) | 2006-02-22 |
| AU2002363368B2 (en) | 2007-12-13 |
| US20060270676A1 (en) | 2006-11-30 |
| KR20050035177A (ko) | 2005-04-15 |
| HUP0401747A2 (hu) | 2005-01-28 |
| ES2268157T3 (es) | 2007-03-16 |
| PL369738A1 (en) | 2005-05-02 |
| BR0213683A (pt) | 2004-10-26 |
| AR040629A1 (es) | 2005-04-13 |
| RU2302412C2 (ru) | 2007-07-10 |
| WO2003039548A1 (en) | 2003-05-15 |
| JP5116940B2 (ja) | 2013-01-09 |
| JP2005511595A (ja) | 2005-04-28 |
| MY129491A (en) | 2007-04-30 |
| EP1441730B1 (en) | 2006-08-09 |
| DE60213841T2 (de) | 2007-02-15 |
| US20040261190A1 (en) | 2004-12-30 |
| EP1441730A1 (en) | 2004-08-04 |
| US7544684B2 (en) | 2009-06-09 |
| HUP0401747A3 (en) | 2005-06-28 |
| MXPA04004263A (es) | 2004-07-08 |
| ATE335486T1 (de) | 2006-09-15 |
| KR100898894B1 (ko) | 2009-05-21 |
| AU2002363368B9 (en) | 2003-05-19 |
| DE60213841D1 (de) | 2006-09-21 |
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