CA2464735C - Solution d'inhalation a base d'albuterol et d'ipratropium, et systeme, kit et methode permettant de soulager les symptomes de la bronchopneumopathie chronique obstructive - Google Patents

Solution d'inhalation a base d'albuterol et d'ipratropium, et systeme, kit et methode permettant de soulager les symptomes de la bronchopneumopathie chronique obstructive Download PDF

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Publication number
CA2464735C
CA2464735C CA2464735A CA2464735A CA2464735C CA 2464735 C CA2464735 C CA 2464735C CA 2464735 A CA2464735 A CA 2464735A CA 2464735 A CA2464735 A CA 2464735A CA 2464735 C CA2464735 C CA 2464735C
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CA
Canada
Prior art keywords
inhalation solution
albuterol
solution
inhalation
containers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2464735A
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English (en)
Other versions
CA2464735A1 (fr
Inventor
Imtiaz Chaudry
Partha Banerjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Specialty LP
Original Assignee
Dey LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002158304A external-priority patent/JP2003221335A/ja
Application filed by Dey LP filed Critical Dey LP
Publication of CA2464735A1 publication Critical patent/CA2464735A1/fr
Application granted granted Critical
Publication of CA2464735C publication Critical patent/CA2464735C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Solution d'inhalation à base de deux bronchodilatateurs, et système, kit et méthode permettant de soulager le bronchospasme chez les patients souffrant de bronchopneumopathie chronique obstructive. Dans un mode de réalisation, la solution selon la présente invention est une dose unitaire préemballée, stérile, prémélangée et prémesurée d'albutérol et de bromure d'ipratropium pour des patients souffrant de bronchopneumopathie chronique obstructive. Cette solution peut être exempte de produits chimiques anti-microbiens tels que le chlorure de benzalconium. Dans un autre mode de réalisation, la solution selon la présente invention contient environ 2,50 mg d'albutérol et environ 0,50 mg de bromure d'ipratropium.
CA2464735A 2001-10-26 2002-10-18 Solution d'inhalation a base d'albuterol et d'ipratropium, et systeme, kit et methode permettant de soulager les symptomes de la bronchopneumopathie chronique obstructive Expired - Fee Related CA2464735C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US34607801P 2001-10-26 2001-10-26
US60/346,078 2001-10-26
US10/034,657 2001-12-27
US3465701A 2001-12-28 2001-12-28
AU32974/02A AU3297402A (en) 2001-10-26 2002-04-05 An albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
AU32974/02 2002-04-05
JP2002158304A JP2003221335A (ja) 2001-10-26 2002-04-23 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法
JP2002-158304 2002-04-23
PCT/US2002/033353 WO2003037159A2 (fr) 2001-10-26 2002-10-18 Solution d'inhalation a base d'albuterol et d'ipratropium, et systeme, kit et methode permettant de soulager les symptomes de la bronchopneumopathie chronique obstructive

Publications (2)

Publication Number Publication Date
CA2464735A1 CA2464735A1 (fr) 2003-05-08
CA2464735C true CA2464735C (fr) 2011-03-22

Family

ID=27422968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2464735A Expired - Fee Related CA2464735C (fr) 2001-10-26 2002-10-18 Solution d'inhalation a base d'albuterol et d'ipratropium, et systeme, kit et methode permettant de soulager les symptomes de la bronchopneumopathie chronique obstructive

Country Status (8)

Country Link
EP (1) EP1446045A4 (fr)
JP (1) JP2006505486A (fr)
CN (2) CN1939279A (fr)
AU (1) AU3297402A (fr)
CA (1) CA2464735C (fr)
MX (1) MXPA04003927A (fr)
NZ (1) NZ552548A (fr)
WO (1) WO2003037159A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1915985A1 (fr) * 2003-03-20 2008-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulation pour une dose mesurée utilisant des hydro-fluoro-alcanes en tant que propulseurs
GB0501956D0 (en) * 2005-01-31 2005-03-09 Arrow Internat Nebulizer formulation
JP2009537570A (ja) * 2006-05-18 2009-10-29 ティカ レーケメデル アーベー アルブテロールの吸入可能溶液を有する単位用量製剤
WO2007134965A1 (fr) * 2006-05-19 2007-11-29 Boehringer Ingelheim International Gmbh Formulation d'aérosol contenant du bromure d'ipratropium et du sulfate de salbutamol
EP2026785A1 (fr) * 2006-05-19 2009-02-25 Boehringer Ingelheim International GmbH Formulation d'aérosol sans gaz propulseur destinée à être inhalée, contenant du bromure d'ipratropium et du sulfate de salbutamol
EP2077132A1 (fr) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
EP2414560B1 (fr) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Procédé de revêtement d'une surface d'un composant
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
CN102686260B (zh) 2009-11-25 2014-10-01 贝林格尔.英格海姆国际有限公司 喷雾器
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
WO2012106382A1 (fr) * 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Composés analogues de pyridone et de pirfénidone en aérosol, et leurs utilisations
WO2012130757A1 (fr) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Appareil médical pourvu d'un récipient
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (fr) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Pulvérisateur comprenant des moyens de détrompage
JP6643231B2 (ja) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
PL2835146T3 (pl) 2013-08-09 2021-04-06 Boehringer Ingelheim International Gmbh Nebulizator
DK2897589T3 (en) * 2013-11-22 2018-03-12 Teva Branded Pharmaceutical Prod R & D Inc Inhalable drug
PL2897588T3 (pl) * 2013-11-22 2019-12-31 Teva Branded Pharmaceutical Products R&D, Inc. Lek wziewny
US10716907B2 (en) 2014-05-07 2020-07-21 Boehringer Ingelheim International Gmbh Nebulizer
ES2954961T3 (es) 2014-05-07 2023-11-27 Boehringer Ingelheim Int Unidad, nebulizador y método
PL3139984T3 (pl) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizator
CN106344544A (zh) * 2016-08-25 2017-01-25 杭州百诚医药科技股份有限公司 一种用于治疗支气管哮喘的雾化吸入制剂
CN110898042B (zh) * 2019-12-12 2020-10-16 深圳大佛药业股份有限公司 一种吸入用硫酸沙丁胺醇溶液剂及其制备方法
CN111053761B (zh) * 2020-01-16 2022-05-03 杭州旦承医药科技有限公司 一种吸入用双膦酸类药物及其制备方法及其在慢性阻塞性肺疾病的用途
WO2021188809A1 (fr) * 2020-03-19 2021-09-23 Cai Gu Huang Formulation inhalable d'une solution contenant du tartrate de lévalbutérol
CN113018280A (zh) * 2021-03-01 2021-06-25 石家庄四药有限公司 一种异丙托溴铵吸入用溶液制剂及其制备方法
CN115645381B (zh) * 2022-10-20 2023-05-30 深圳大佛药业股份有限公司 一种盐酸左沙丁胺醇雾化吸入溶液缓释剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0673240B1 (fr) * 1992-12-09 1999-03-24 Boehringer Ingelheim Pharmaceuticals Inc. Formulations de solutions medicinales aerosol stabilisees
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US6247617B1 (en) * 1999-12-13 2001-06-19 Richard Allen Clyde Single use container for dispensing separately housed sterile compositions

Also Published As

Publication number Publication date
CA2464735A1 (fr) 2003-05-08
JP2006505486A (ja) 2006-02-16
WO2003037159A2 (fr) 2003-05-08
AU3297402A (en) 2003-10-30
MXPA04003927A (es) 2005-03-31
EP1446045A4 (fr) 2010-07-21
CN1607940A (zh) 2005-04-20
EP1446045A2 (fr) 2004-08-18
WO2003037159A3 (fr) 2003-10-16
NZ552548A (en) 2009-03-31
CN1939279A (zh) 2007-04-04

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