CA2461890C - Nanoparticules solubles dans l'eau constituees de materiaux hydrophiles et hydrophobes - Google Patents

Nanoparticules solubles dans l'eau constituees de materiaux hydrophiles et hydrophobes Download PDF

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Publication number
CA2461890C
CA2461890C CA2461890A CA2461890A CA2461890C CA 2461890 C CA2461890 C CA 2461890C CA 2461890 A CA2461890 A CA 2461890A CA 2461890 A CA2461890 A CA 2461890A CA 2461890 C CA2461890 C CA 2461890C
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CA
Canada
Prior art keywords
active compound
nano
polymer
recited
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2461890A
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English (en)
Other versions
CA2461890A1 (fr
Inventor
Rina Goldshtein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SoluBest Ltd
Original Assignee
SoluBest Ltd
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Filing date
Publication date
Priority claimed from US09/966,847 external-priority patent/US6878693B2/en
Application filed by SoluBest Ltd filed Critical SoluBest Ltd
Publication of CA2461890A1 publication Critical patent/CA2461890A1/fr
Application granted granted Critical
Publication of CA2461890C publication Critical patent/CA2461890C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

L'invention concerne des particules nanométriques solubles formées d'un noyau (composé lipophile insoluble dans l'eau ou composé hydrophile) et d'un polymère amphiphile, lesdites particules présentant une meilleure solubilité et/ou stabilité. Ledit composé lipophile desdites particules nanométriques solubles peut se présenter sous la forme de composés pharmaceutiques, d'additifs alimentaires, d'agents cosmétiques, de produits agricoles et vétérinaires. L'invention concerne également de nouveaux procédés de fabrication desdites particules nanométriques solubles, ainsi qu'un nouveau réacteur chimique destiné à la fabrication d'un complexe d'inclusion contenant lesdites particules nanométriques solubles.
CA2461890A 2001-09-28 2002-09-27 Nanoparticules solubles dans l'eau constituees de materiaux hydrophiles et hydrophobes Expired - Fee Related CA2461890C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/966,847 2001-09-28
US09/966,847 US6878693B2 (en) 2001-09-28 2001-09-28 Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
US10/256,023 2002-09-26
US10/256,023 US7081450B2 (en) 2001-09-28 2002-09-26 Water soluble nanoparticles of hydrophilic and hydrophobic active materials and an apparatus and method for their production
PCT/IB2002/004176 WO2003028700A2 (fr) 2001-09-28 2002-09-27 Nanoparticules solubles dans l'eau constituees de materiaux hydrophiles et hydrophobes et dispositif et procede de fabrication de celles-ci

Publications (2)

Publication Number Publication Date
CA2461890A1 CA2461890A1 (fr) 2003-04-10
CA2461890C true CA2461890C (fr) 2010-12-14

Family

ID=32474076

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2461890A Expired - Fee Related CA2461890C (fr) 2001-09-28 2002-09-27 Nanoparticules solubles dans l'eau constituees de materiaux hydrophiles et hydrophobes

Country Status (5)

Country Link
EP (1) EP1448174A2 (fr)
JP (1) JP2005507393A (fr)
CA (1) CA2461890C (fr)
IL (1) IL160957A0 (fr)
WO (1) WO2003028700A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014342A1 (fr) 2002-08-12 2004-02-19 Pfizer Products Inc. Compositions pharmaceutiques de medicaments partiellement ordonnes et de polymeres
US20060039948A1 (en) * 2002-11-14 2006-02-23 Gunther Schmid Implant, therapeutic agent and micelle
CA2540104A1 (fr) * 2003-09-30 2005-04-07 Solubest Ltd. Nanoparticules hydrosolubles et leur procede de production
CN101040848B (zh) * 2007-04-19 2010-05-19 上海交通大学 两亲性聚合物载药纳米粒子的制备方法
PL2200588T3 (pl) * 2007-09-25 2019-09-30 Solubest Ltd. Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania
JP6360040B2 (ja) * 2012-05-03 2018-07-18 カラ ファーマシューティカルズ インコーポレイテッド 粘液浸透性被覆粒子、組成物、医薬組成物、医薬製剤、及びそれらの形成方法
KR101610465B1 (ko) 2014-04-11 2016-04-07 국립암센터 다목적용 의료 영상 표지자 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766635A (en) * 1991-06-28 1998-06-16 Rhone-Poulenc Rorer S.A. Process for preparing nanoparticles
JP3072340B2 (ja) * 1991-10-21 2000-07-31 ポーラ化成工業株式会社 水性目薬及びその製造法
AU6546496A (en) * 1995-07-26 1997-02-26 Nanosystems L.L.C. Methacrylate backbone surfactants in nanoparticulate formulations
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
AU4373499A (en) * 1999-06-02 2000-12-28 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
EP1258241A1 (fr) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Procédé permettant d'accroitre la biodisponibilité de nimesulide

Also Published As

Publication number Publication date
EP1448174A2 (fr) 2004-08-25
IL160957A0 (en) 2004-08-31
CA2461890A1 (fr) 2003-04-10
WO2003028700A3 (fr) 2004-06-17
WO2003028700A2 (fr) 2003-04-10
JP2005507393A (ja) 2005-03-17

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Effective date: 20130927