CA2456727A1 - System for fluorescent diagnosis - Google Patents
System for fluorescent diagnosis Download PDFInfo
- Publication number
- CA2456727A1 CA2456727A1 CA002456727A CA2456727A CA2456727A1 CA 2456727 A1 CA2456727 A1 CA 2456727A1 CA 002456727 A CA002456727 A CA 002456727A CA 2456727 A CA2456727 A CA 2456727A CA 2456727 A1 CA2456727 A1 CA 2456727A1
- Authority
- CA
- Canada
- Prior art keywords
- image
- fluorescent
- light source
- opto
- foregoing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003745 diagnosis Methods 0.000 title claims description 10
- 230000005284 excitation Effects 0.000 claims abstract description 21
- 230000004913 activation Effects 0.000 claims abstract description 4
- 210000000056 organ Anatomy 0.000 claims abstract 2
- 230000003595 spectral effect Effects 0.000 claims description 7
- 239000007850 fluorescent dye Substances 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 230000001960 triggered effect Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 230000005693 optoelectronics Effects 0.000 abstract 1
- 150000004032 porphyrins Chemical class 0.000 description 4
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 229950003776 protoporphyrin Drugs 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 1
- 229960002749 aminolevulinic acid Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7285—Specific aspects of physiological measurement analysis for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10139239 | 2001-08-09 | ||
| DE10139239.7 | 2001-08-09 | ||
| DE10157575A DE10157575A1 (de) | 2001-08-09 | 2001-11-23 | System für die Fluoreszenzdiagnostik |
| DE10157575.0 | 2001-11-23 | ||
| PCT/DE2002/002818 WO2003016878A2 (de) | 2001-08-09 | 2002-08-01 | System für die fluoreszenzdiagnostik |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2456727A1 true CA2456727A1 (en) | 2003-02-27 |
Family
ID=26009916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002456727A Abandoned CA2456727A1 (en) | 2001-08-09 | 2002-08-01 | System for fluorescent diagnosis |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20050253087A1 (enExample) |
| EP (1) | EP1414336B1 (enExample) |
| JP (1) | JP2004538485A (enExample) |
| CA (1) | CA2456727A1 (enExample) |
| WO (1) | WO2003016878A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005013043A1 (de) * | 2005-03-18 | 2006-09-28 | Siemens Ag | Mobiler Fluoreszenz-Scanner für molekulare Signaturen |
| US20070238997A1 (en) * | 2006-03-29 | 2007-10-11 | Estelle Camus | Ultrasound and fluorescence imaging |
| DE102007034936A1 (de) | 2007-07-23 | 2009-01-29 | Friedrich-Schiller-Universität Jena | Vorrichtung zur Erkennung schwach fluoreszierender Areale mit maximalem Kontrast |
| DE102007054602A1 (de) * | 2007-11-15 | 2009-05-28 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Verfahren und Messaufbau zum Erfassen der Verteilung mindestens einer Zustandsgröße in einem Messfeld mit verschiedenen Sonden |
| US8956591B2 (en) | 2008-05-15 | 2015-02-17 | Osaka Prefectural Hospital Organization | Method for detecting cancer using ICG fluorescence method |
| DE102010061182B4 (de) | 2010-12-13 | 2013-02-07 | Presens Precision Sensing Gmbh | Sensoranordnung, Verfahren und Messsystem zur Erfassung der Verteilung wenigstens einer Veränderlichen eines Objekts |
| US9625386B2 (en) | 2014-09-10 | 2017-04-18 | Iwasaki Electric Co., Ltd. | Imaging system |
| US10209242B2 (en) * | 2015-05-21 | 2019-02-19 | Emit Imaging, Inc. | Fluorescence histo-tomography (FHT) systems and methods |
| WO2017040671A1 (en) * | 2015-08-31 | 2017-03-09 | Invicro, Llc | Fluorescence histo-tomography (fht) systems and methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60256443A (ja) * | 1984-05-31 | 1985-12-18 | オムロン株式会社 | 画像計測装置 |
| US5749830A (en) * | 1993-12-03 | 1998-05-12 | Olympus Optical Co., Ltd. | Fluorescent endoscope apparatus |
| JPH07336501A (ja) * | 1994-06-08 | 1995-12-22 | Minolta Co Ltd | 光源を含んだ撮像システム |
| JP3602207B2 (ja) * | 1995-07-12 | 2004-12-15 | 富士写真フイルム株式会社 | 手術用蛍光画像撮像装置 |
| JP4433347B2 (ja) * | 2000-01-17 | 2010-03-17 | 富士フイルム株式会社 | 蛍光撮像装置 |
| US6454710B1 (en) * | 2001-04-11 | 2002-09-24 | Motorola, Inc. | Devices and methods for monitoring an analyte |
-
2002
- 2002-08-01 WO PCT/DE2002/002818 patent/WO2003016878A2/de not_active Ceased
- 2002-08-01 US US10/485,256 patent/US20050253087A1/en not_active Abandoned
- 2002-08-01 EP EP02754464A patent/EP1414336B1/de not_active Expired - Lifetime
- 2002-08-01 CA CA002456727A patent/CA2456727A1/en not_active Abandoned
- 2002-08-01 JP JP2003521335A patent/JP2004538485A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003016878A2 (de) | 2003-02-27 |
| EP1414336A2 (de) | 2004-05-06 |
| EP1414336B1 (de) | 2010-05-26 |
| WO2003016878A3 (de) | 2003-07-31 |
| JP2004538485A (ja) | 2004-12-24 |
| US20050253087A1 (en) | 2005-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20130204 |