CA2454644C - Formulations de cannabinoides liquides administrees par les muqueuses - Google Patents

Formulations de cannabinoides liquides administrees par les muqueuses Download PDF

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Publication number
CA2454644C
CA2454644C CA2454644A CA2454644A CA2454644C CA 2454644 C CA2454644 C CA 2454644C CA 2454644 A CA2454644 A CA 2454644A CA 2454644 A CA2454644 A CA 2454644A CA 2454644 C CA2454644 C CA 2454644C
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CA
Canada
Prior art keywords
thc
formulation
cbd
solvent
cannabinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2454644A
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English (en)
Other versions
CA2454644A1 (fr
Inventor
Brian Anthony Whittle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GW Research Ltd
Original Assignee
GW Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0218930A external-priority patent/GB2392093B/en
Priority claimed from US10/218,989 external-priority patent/US6946150B2/en
Application filed by GW Pharma Ltd filed Critical GW Pharma Ltd
Publication of CA2454644A1 publication Critical patent/CA2454644A1/fr
Application granted granted Critical
Publication of CA2454644C publication Critical patent/CA2454644C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention se rapporte à des préparations pharmaceutiques, et plus particulièrement à des préparations contenant des cannabinoïdes, destinées à être administrées par un aérosol à pompe. Plus précisément, l'invention concerne des préparations pharmaceutiques destinées à servir à l'administration, par l'intermédiaire de muqueuses, de médicaments lipophiles contenant un ou plusieurs cannabinoïdes. Ladite préparation comprend : au moins un médicament lipophile renfermant un ou plusieurs cannabinoïdes, un solvant et un cosolvant, la proportion totale de solvant et de cosolvant dans la préparation étant supérieure à 55 % poids / poids de la préparation ; ladite préparation est exempte d'agent émulsifiant et/ou de propulseur fluoré, et le ou les cannabinoïdes sont présents dans la préparation en une proportion supérieure à 10 mg/ml.
CA2454644A 2002-08-14 2003-08-14 Formulations de cannabinoides liquides administrees par les muqueuses Expired - Lifetime CA2454644C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/218,989 2002-08-14
GB0218930A GB2392093B (en) 2002-08-14 2002-08-14 Pharmaceutical formulations
GB0218930.6 2002-08-14
US10/218,989 US6946150B2 (en) 2002-08-14 2002-08-14 Pharmaceutical formulation
PCT/GB2003/003574 WO2004016246A1 (fr) 2002-08-14 2003-08-14 Preparations liquides cannabinoides destinees a etre administrees par muqueuses

Publications (2)

Publication Number Publication Date
CA2454644A1 CA2454644A1 (fr) 2004-02-14
CA2454644C true CA2454644C (fr) 2014-09-16

Family

ID=31889678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2454644A Expired - Lifetime CA2454644C (fr) 2002-08-14 2003-08-14 Formulations de cannabinoides liquides administrees par les muqueuses

Country Status (16)

Country Link
EP (2) EP1542657B8 (fr)
JP (1) JP4515908B2 (fr)
KR (1) KR101008609B1 (fr)
AT (1) ATE533472T1 (fr)
AU (2) AU2003253005B2 (fr)
CA (1) CA2454644C (fr)
CY (1) CY1112523T1 (fr)
DK (2) DK1542657T3 (fr)
ES (2) ES2625605T3 (fr)
FR (1) FR14C0025I2 (fr)
LU (1) LU92233I2 (fr)
MX (1) MXPA05001567A (fr)
PL (1) PL215220B1 (fr)
PT (2) PT2314284T (fr)
SI (1) SI1542657T1 (fr)
WO (1) WO2004016246A1 (fr)

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GB2450753B (en) * 2007-07-06 2012-07-18 Gw Pharma Ltd New Pharmaceutical formulation
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Also Published As

Publication number Publication date
EP1542657B1 (fr) 2011-11-16
EP2314284A3 (fr) 2012-05-09
JP2006504671A (ja) 2006-02-09
WO2004016246A1 (fr) 2004-02-26
KR101008609B1 (ko) 2011-01-17
AU2003253005B2 (en) 2009-03-19
ES2377819T3 (es) 2012-04-02
MXPA05001567A (es) 2005-04-25
CY1112523T1 (el) 2015-12-09
KR20050042157A (ko) 2005-05-04
PL215220B1 (pl) 2013-11-29
EP1542657A1 (fr) 2005-06-22
EP1542657B8 (fr) 2012-03-14
PT1542657E (pt) 2012-02-29
CA2454644A1 (fr) 2004-02-14
SI1542657T1 (sl) 2012-04-30
JP4515908B2 (ja) 2010-08-04
DK2314284T3 (en) 2017-05-22
FR14C0025I1 (fr) 2014-08-08
AU2009202434B2 (en) 2012-08-30
ES2625605T3 (es) 2017-07-20
AU2003253005A1 (en) 2004-03-03
DK1542657T3 (da) 2012-03-05
EP2314284A2 (fr) 2011-04-27
PT2314284T (pt) 2017-05-25
LU92233I2 (fr) 2013-08-26
PL375224A1 (en) 2005-11-28
ATE533472T1 (de) 2011-12-15
EP2314284B1 (fr) 2017-02-15
FR14C0025I2 (fr) 2014-11-14
AU2009202434A1 (en) 2009-07-09

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