CA2450950A1 - Chemically-modified progenipoietin conjugates - Google Patents

Chemically-modified progenipoietin conjugates Download PDF

Info

Publication number
CA2450950A1
CA2450950A1 CA002450950A CA2450950A CA2450950A1 CA 2450950 A1 CA2450950 A1 CA 2450950A1 CA 002450950 A CA002450950 A CA 002450950A CA 2450950 A CA2450950 A CA 2450950A CA 2450950 A1 CA2450950 A1 CA 2450950A1
Authority
CA
Canada
Prior art keywords
leu
ser
pro
glu
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002450950A
Other languages
English (en)
French (fr)
Inventor
Ned R. Siegel
Rory F. Finn
Robert L. Hills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2450950A1 publication Critical patent/CA2450950A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA002450950A 2001-06-22 2002-06-14 Chemically-modified progenipoietin conjugates Abandoned CA2450950A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30036201P 2001-06-22 2001-06-22
US60/300,362 2001-06-22
PCT/US2002/018810 WO2003000179A2 (en) 2001-06-22 2002-06-14 Chemically-modified progenipoietin conjugates

Publications (1)

Publication Number Publication Date
CA2450950A1 true CA2450950A1 (en) 2003-01-03

Family

ID=23158770

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450950A Abandoned CA2450950A1 (en) 2001-06-22 2002-06-14 Chemically-modified progenipoietin conjugates

Country Status (15)

Country Link
US (1) US20060052291A1 (https=)
EP (1) EP1404354A4 (https=)
JP (1) JP2005512951A (https=)
KR (1) KR20040069980A (https=)
CN (1) CN101426511A (https=)
BR (1) BR0211192A (https=)
CA (1) CA2450950A1 (https=)
CZ (1) CZ20033537A3 (https=)
EA (1) EA006368B1 (https=)
IL (1) IL159496A0 (https=)
MX (1) MXPA04000068A (https=)
NO (1) NO20035742L (https=)
PL (1) PL367410A1 (https=)
WO (1) WO2003000179A2 (https=)
ZA (1) ZA200309863B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006215823A1 (en) * 2005-02-16 2006-08-24 Micromet Ag Use of activated polymers for separation of protein and polypeptide multimers
WO2006102659A2 (en) * 2005-03-23 2006-09-28 Nektar Therapeutics Al, Corporation CONJUGATES OF AN hGH MOIETY AND A POLYMER
US8951769B2 (en) 2009-04-20 2015-02-10 The Regents Of The University Of California Engineered demeter 5-methylcytosine DNA glyosylase with improved yield, stability and solubility
KR200483859Y1 (ko) 2015-10-28 2017-07-04 주식회사 키유틸리티 충전장치 수납 및 휴대용 기기 거치용 장치
WO2019075053A1 (en) * 2017-10-11 2019-04-18 Elanco Us Inc. PORCINE G-CSF VARIANTS AND USES THEREOF
CN111741770A (zh) * 2017-12-29 2020-10-02 豪夫迈·罗氏有限公司 用于提供聚乙二醇化蛋白质组合物的方法
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69431295T2 (de) * 1993-04-21 2003-05-15 Institut Pasteur, Paris Biokompatibles implantat zur in vivo expression und sekretion von therapeutischer verbindung
US5730990A (en) * 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
GB2294047A (en) * 1994-10-14 1996-04-17 Merck & Co Inc Synthetic peptides for use as epitopes specific for HIV
SE507527C2 (sv) * 1996-10-11 1998-06-15 Ericsson Telefon Ab L M Flerbandsmottagare som genererar en mellanfrekvens som är gemensam för de olika frekvensbanden, och förfarande för densamma
US6251665B1 (en) * 1997-02-07 2001-06-26 Cem Cezayirli Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom

Also Published As

Publication number Publication date
EA006368B1 (ru) 2005-12-29
KR20040069980A (ko) 2004-08-06
WO2003000179A2 (en) 2003-01-03
BR0211192A (pt) 2004-10-26
CZ20033537A3 (cs) 2004-08-18
NO20035742D0 (no) 2003-12-19
WO2003000179A3 (en) 2003-12-11
PL367410A1 (en) 2005-02-21
NO20035742L (no) 2004-02-23
ZA200309863B (https=) 2006-06-28
CN101426511A (zh) 2009-05-06
US20060052291A1 (en) 2006-03-09
JP2005512951A (ja) 2005-05-12
EP1404354A2 (en) 2004-04-07
IL159496A0 (en) 2004-06-01
EA200400070A1 (ru) 2004-06-24
MXPA04000068A (es) 2005-06-06
EP1404354A4 (en) 2005-04-20

Similar Documents

Publication Publication Date Title
JP3747070B2 (ja) 改良型インターフェロン−ポリマーコンジュゲート
KR100303810B1 (ko) 거핵구성장및분화를자극하기위한조성물및방법
AU634343B2 (en) Modified hil-6
JP5336372B2 (ja) G−csf部位特異的モノコンジュゲート
US5711944A (en) Interferon polymer conjugates
CA2978330C (en) Conjugates of an il-7 moiety and a polymer
JP2009503111A (ja) G−csf部分および重合体の複合体
Eliason Pegylated cytokines: potential application in immunotherapy of cancer
KR101330338B1 (ko) Gm―csf 부분 및 중합체의 콘쥬게이트
CA2450950A1 (en) Chemically-modified progenipoietin conjugates
WO2001076639A2 (en) Chemically-modified myelopoietin conjugates
KR20070010817A (ko) 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
TW201138831A (en) Modified granulocyte colony stimulating factor (G-CSF)
US20090203589A1 (en) Chemically modified human growth hormone receptor antagonist conjugates
AU2002315117A1 (en) Chemically-modified progenipoietin conjugates
JP2004501975A (ja) ケモカイン結合体
Eliason PEGylated proteins in immunotherapy of cancer
Gao by Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports
PL183631B1 (pl) Pochodna polipeptydu stanowiącego czynnik wzrostu i rozwoju megakariocytów-(polipeptydu MGDF), sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca taką pochodną
HK1190736B (en) Mono- and di-peg il-10 production and uses
HK1190736A1 (zh) 单和双peg il10的生产和用途

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20080616