CA2450691A1 - Genes and proteins involved in the biosynthesis of lipopeptides - Google Patents

Genes and proteins involved in the biosynthesis of lipopeptides Download PDF

Info

Publication number
CA2450691A1
CA2450691A1 CA002450691A CA2450691A CA2450691A1 CA 2450691 A1 CA2450691 A1 CA 2450691A1 CA 002450691 A CA002450691 A CA 002450691A CA 2450691 A CA2450691 A CA 2450691A CA 2450691 A1 CA2450691 A1 CA 2450691A1
Authority
CA
Canada
Prior art keywords
lipopeptides
biosynthesis
genes
proteins involved
lipopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002450691A
Other languages
French (fr)
Other versions
CA2450691C (en
Inventor
Chris M. Farnet
Emmanuel Zazopoulos
Alfredo Staffa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from CA002412627A external-priority patent/CA2412627A1/en
Publication of CA2450691A1 publication Critical patent/CA2450691A1/en
Application granted granted Critical
Publication of CA2450691C publication Critical patent/CA2450691C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Genes and proteins involved in the biosynthesis of lipopeptides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the A54145 lipopeptide from Streptomyces fradiae and the A54145-like lipopeptide from Streptomyces refuineus. These nucleic acids can be used to make expression constructs and transformed host cells for the production of lipopeptides. The genes and proteins allow direct manipulation of lipopeptides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of A54145.
CA002450691A 2001-12-26 2002-12-24 Genes and proteins involved in the biosynthesis of lipopeptides Expired - Fee Related CA2450691C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34213301P 2001-12-26 2001-12-26
US60/342,133 2001-12-26
US37278902P 2002-04-17 2002-04-17
US60/372,789 2002-04-17
CA002412627A CA2412627A1 (en) 2001-12-26 2002-12-24 Genes and proteins involved in the biosynthesis of lipopeptides

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002412627A Division CA2412627A1 (en) 2001-12-26 2002-12-24 Genes and proteins involved in the biosynthesis of lipopeptides

Publications (2)

Publication Number Publication Date
CA2450691A1 true CA2450691A1 (en) 2003-06-26
CA2450691C CA2450691C (en) 2009-05-26

Family

ID=32073642

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450691A Expired - Fee Related CA2450691C (en) 2001-12-26 2002-12-24 Genes and proteins involved in the biosynthesis of lipopeptides

Country Status (1)

Country Link
CA (1) CA2450691C (en)

Also Published As

Publication number Publication date
CA2450691C (en) 2009-05-26

Similar Documents

Publication Publication Date Title
EP2484687A3 (en) Methods and compositions for seamless cloning of nucleic acid molecules
WO2004099387A3 (en) siRNA INDUCED SYSTEMIC GENE SILENCING IN MAMMALIAN SYSTEMS
BR0010806A (en) Methods and materials for the synthesis of organic products
WO2001064920A3 (en) Hybrid expression of neisserial proteins
EP2327774A3 (en) Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
EP1808180A3 (en) Modified GP 100 and uses thereof
AU1231701A (en) Production of polyketides
EP1576160B8 (en) Borrelidin-derivatives and their use in medicine
WO2002079395A3 (en) Carotenoid biosynthesis
WO2003006613A3 (en) Methods for ex vivo propagation of somatic stem cells
WO2001059126A3 (en) Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility
AU2002355157A1 (en) Genes and proteins for the biosynthesis of rosaramicin
WO2003060127A3 (en) Genes and proteins involved in the biosynthesis of lipopeptides
CA2450691A1 (en) Genes and proteins involved in the biosynthesis of lipopeptides
WO2002020797A3 (en) Genes encoding polypeptides from methylomonas sp. involved exopolysaccharide production
AU2002254822A1 (en) Genes and proteins for the biosynthesis of polyketides
AU2002211843A1 (en) 2.5-diketo-d-gluconic acid reductases and methods of use
WO2002006508A3 (en) CYCLOMALTODEXTRIN GLUCANOTRANSFERASE (CGTase9, DNA SEQUENCE ENCODING IT AND USES THEREOF
AP2002002419A0 (en) Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins.
EP1283868A4 (en) Isolated gum operon from xyllela fastidiosa, isolated nucleic acid molecules therefrom, and uses thereof
BG104759A (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
AP2002002418A0 (en) Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins.
AU2001252825A1 (en) Thieno(2,3-d)pyrimidinediones and their use as pharmaceuticals
RS70004A (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectin
WO2002044391A3 (en) Methods and compositions for the introduction of molecules into cells

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed