WO2002079395A3 - Carotenoid biosynthesis - Google Patents

Carotenoid biosynthesis Download PDF

Info

Publication number
WO2002079395A3
WO2002079395A3 PCT/US2002/002124 US0202124W WO02079395A3 WO 2002079395 A3 WO2002079395 A3 WO 2002079395A3 US 0202124 W US0202124 W US 0202124W WO 02079395 A3 WO02079395 A3 WO 02079395A3
Authority
WO
WIPO (PCT)
Prior art keywords
carotenoid biosynthesis
carotenoids
microorganisms
well
nucleic acids
Prior art date
Application number
PCT/US2002/002124
Other languages
French (fr)
Other versions
WO2002079395A9 (en
WO2002079395A2 (en
Inventor
Souza Mervyn L De
Sherry R Kollmann
Colleen A May
William A Schroeder
Original Assignee
Cargill Inc
Souza Mervyn L De
Sherry R Kollmann
Colleen A May
William A Schroeder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc, Souza Mervyn L De, Sherry R Kollmann, Colleen A May, William A Schroeder filed Critical Cargill Inc
Priority to US10/466,656 priority Critical patent/US20040078846A1/en
Priority to CA002436366A priority patent/CA2436366A1/en
Priority to AU2002311758A priority patent/AU2002311758A1/en
Priority to JP2002578398A priority patent/JP2004528839A/en
Priority to EP02739081A priority patent/EP1377598A4/en
Publication of WO2002079395A2 publication Critical patent/WO2002079395A2/en
Publication of WO2002079395A9 publication Critical patent/WO2002079395A9/en
Priority to NO20033353A priority patent/NO20033353L/en
Publication of WO2002079395A3 publication Critical patent/WO2002079395A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Husbandry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Membranous bacteria that produce astaxanthin and other carotenoids are described, as well as isolated nucleic acids and expression vectors that can be used for producing carotenoids in microorganisms.
PCT/US2002/002124 2001-01-26 2002-01-25 Carotenoid biosynthesis WO2002079395A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/466,656 US20040078846A1 (en) 2002-01-25 2002-01-25 Carotenoid biosynthesis
CA002436366A CA2436366A1 (en) 2001-01-26 2002-01-25 Carotenoid biosynthesis
AU2002311758A AU2002311758A1 (en) 2001-01-26 2002-01-25 Carotenoid biosynthesis
JP2002578398A JP2004528839A (en) 2001-01-26 2002-01-25 Carotenoid biosynthesis
EP02739081A EP1377598A4 (en) 2001-01-26 2002-01-25 Carotenoid biosynthesis
NO20033353A NO20033353L (en) 2001-01-26 2003-07-25 Carotenoid biosynthesis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26432901P 2001-01-26 2001-01-26
US60/264,329 2001-01-26
US28898401P 2001-05-04 2001-05-04
US60/288,984 2001-05-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/848,307 Continuation-In-Part US20050003474A1 (en) 2001-01-26 2004-05-18 Carotenoid biosynthesis

Publications (3)

Publication Number Publication Date
WO2002079395A2 WO2002079395A2 (en) 2002-10-10
WO2002079395A9 WO2002079395A9 (en) 2003-06-05
WO2002079395A3 true WO2002079395A3 (en) 2003-10-23

Family

ID=26950419

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002124 WO2002079395A2 (en) 2001-01-26 2002-01-25 Carotenoid biosynthesis

Country Status (6)

Country Link
EP (1) EP1377598A4 (en)
JP (1) JP2004528839A (en)
AU (1) AU2002311758A1 (en)
CA (1) CA2436366A1 (en)
NO (1) NO20033353L (en)
WO (1) WO2002079395A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US20030148319A1 (en) * 2001-08-15 2003-08-07 Brzostowicz Patricia C. Genes encoding carotenoid compounds
US7063955B2 (en) 2001-11-20 2006-06-20 E. I. Du Pont De Nemours And Company Method for production of asymmetric carotenoids
US20040151761A1 (en) * 2003-02-05 2004-08-05 The Procter & Gamble Company Methods and compositions utilizing astaxanthin
US7070952B2 (en) 2003-05-07 2006-07-04 E. I. Du Pont Nemours And Company Genes encoding carotenoid compounds
US7064196B2 (en) 2003-05-20 2006-06-20 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
US6929928B2 (en) * 2003-06-12 2005-08-16 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
DE102004007624A1 (en) * 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Preparation of ketocarotenoids, useful in foods and animal feeds, by growing genetically modified organism, particularly plant, having altered ketolase activity
DE102004007622A1 (en) * 2004-02-17 2005-08-25 Sungene Gmbh & Co. Kgaa Preparation of ketocarotenoids, useful in foods and animal feeds, by growing genetically modified organism that has altered activity of ketolase and beta-cyclase
WO2005047486A2 (en) 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Biological production of tetradehydrolycopene
DE602004025734D1 (en) 2003-11-18 2010-04-08 Kirin Holdings Kk NEW CAROTENOIDHYDROXYLASEGEN, PROCESS FOR THE PREPARATION OF HYDROXYLATED CAROTENOID AND NEW GERANYLGERANYLPYROPHOSPHATE SYNTHESIS
EP1694854B1 (en) 2003-12-19 2011-09-14 E.I. Du Pont De Nemours And Company Novel carotenoids ketolases
FR2864968B1 (en) * 2004-01-09 2007-10-05 Inst Rech Developpement Ird PROCESS FOR PRODUCING CAROTENOIDS AND BACTERIA IMPLEMENTED
WO2005118812A1 (en) * 2004-06-04 2005-12-15 Marine Biotechnology Institute Co., Ltd. Method of producing astaxanthin or metabolic product thereof by using carotenoid ketolase and carotenoid hydroxylase genes
US7425625B2 (en) 2004-06-08 2008-09-16 E.I. Du Pont De Nemours And Company Carotenoid ketolase genes with improved ketocarotenoid yield
US7091031B2 (en) 2004-08-16 2006-08-15 E. I. Du Pont De Nemours And Company Carotenoid hydroxylase enzymes
US7074604B1 (en) 2004-12-29 2006-07-11 E. I. Du Pont De Nemours And Company Bioproduction of astaxanthin using mutant carotenoid ketolase and carotenoid hydroxylase genes
KR101482081B1 (en) 2005-03-18 2015-01-13 마이크로비아 인크. Production of carotenoids in oleaginous yeast and fungi
US7393671B2 (en) 2006-03-30 2008-07-01 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolases
US7422873B2 (en) 2006-03-31 2008-09-09 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolase
EP2078092A2 (en) 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
AU2010266147A1 (en) * 2009-07-01 2012-01-19 The Regents Of The University Of California Extraction of extracellular terpenoids from microalgae colonies
CN112119951A (en) * 2020-10-30 2020-12-25 西藏自治区农牧科学院水产科学研究所 Method for cultivating parent fish of Gymnocypris cyprinii

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5429939A (en) * 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
US5684238A (en) * 1990-03-02 1997-11-04 Amoco Corporation Biosynthesis of zeaxanthin and glycosylated zeaxanthin in genetically engineered hosts
US5811273A (en) * 1993-12-27 1998-09-22 Kirin Beer Kabushiki Kaisha DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls
US5965795A (en) * 1995-11-24 1999-10-12 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0889241A (en) * 1994-09-30 1996-04-09 Asahi Chem Ind Co Ltd Gene useful for producing beta-carotene and production of beta-carotene

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5429939A (en) * 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
US5684238A (en) * 1990-03-02 1997-11-04 Amoco Corporation Biosynthesis of zeaxanthin and glycosylated zeaxanthin in genetically engineered hosts
US5811273A (en) * 1993-12-27 1998-09-22 Kirin Beer Kabushiki Kaisha DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls
US5965795A (en) * 1995-11-24 1999-10-12 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ARMSTRONG G.A.: "Genetics of eubacterial cartenoid biosynthesis: a colorful tale", ANNU. REV. MICROBIOL., vol. 51, 1997, pages 629 - 659, XP001097791 *
HANNIBAL ET AL.: "Isolation and characterization of canthaxanthin biosynthesis gene from the photosynthetic bacterium bradyrhizobium sp. strain ORS278", J. BACTERIOL., vol. 182, no. 13, July 2000 (2000-07-01), pages 3850 - 3853, XP002965735 *
LIU S.-T.: "Carotenoid-biosynthesis gene as a genes as a genetic marker for the purpose of gene cloning", BIOCHEM. BIOPHYS. RES. COMMU., vol. 195, no. 1, 31 August 1993 (1993-08-31), pages 259 - 263, XP002965734 *
MISAWA ET AL.: "Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in escherichia coli", J. BACTERIOL., vol. 172, no. 12, December 1990 (1990-12-01), pages 6704 - 6712, XP001058972 *
MISAWA ET AL.: "Structure and function analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level", J. BACTERIOL., vol. 177, no. 22, November 1995 (1995-11-01), pages 6575 - 6584, XP000196417 *
See also references of EP1377598A4 *
TO ET AL.: "Analysis of the gene cluster encoding carotenoid biosynthetis in Erwina herbicola Eho13", MICROBIOLOGY, vol. 140, 1994, pages 331 - 339, XP002965736 *

Also Published As

Publication number Publication date
JP2004528839A (en) 2004-09-24
CA2436366A1 (en) 2002-10-10
EP1377598A4 (en) 2005-08-03
WO2002079395A9 (en) 2003-06-05
WO2002079395A2 (en) 2002-10-10
NO20033353L (en) 2003-09-25
EP1377598A2 (en) 2004-01-07
NO20033353D0 (en) 2003-07-25
AU2002311758A1 (en) 2002-10-15

Similar Documents

Publication Publication Date Title
WO2002079395A3 (en) Carotenoid biosynthesis
WO2005072086A3 (en) Optimized bacterial host strains of methylomonas sp.16a
WO2002030463A3 (en) Reduced-viscosity concentrated protein formulations
WO2005005646A3 (en) Fermentation processes and compositions
AU2002235994A1 (en) Method for producing proteins by fermentation of microorganisms from the thermus family, the protein mixture thus obtained and cosmetic compositions containing same
AU2003274906A1 (en) Double stranded rna structures and constructs, and methods for generating and using the same
AU2001242299A1 (en) Fungal transcriptional activator useful in methods for producing polypeptides
WO2006072078A3 (en) Bioproduction of astaxanthin using mutant carotenoid ketolase and cartonenoid hydroxylase genes
WO2006091924A3 (en) Producing carotenoids
WO2006096392A3 (en) Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
AU2002334884A1 (en) Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
AU2003259112A1 (en) Enzymatic process for the preparation of foods, feedstuffs and ingredients therefor
EP1183954A4 (en) Fading inhibitors
AU1231701A (en) Production of polyketides
AU2003266587A1 (en) Enzyme preparation and process for producing food using the same
WO2005033094A3 (en) Methods for the production of 3-methylamino-1-(thiene-2-yl)-propane-1-ol
WO2005037470A3 (en) Encapsulated nanoparticles, products containing the same, and methods for using the same
AU2002336930A1 (en) Method for producing isolated cell cultures, culture medium for cultivating cell cultures and cell culture
EP1539794A4 (en) Benzoate- and anthranilate-inducible promoters
CA2476244A1 (en) Bacterial autolysate
WO2005001039A3 (en) Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof
AU2003273888A1 (en) Astaxanthin production using fed-batch fermentation process byphaffia rhodozyma
WO2005013904A3 (en) Sars nucleic acids, proteins, vaccines, and uses thereof
WO2005012498A3 (en) Production of porphyrins
EP1591520A3 (en) Microorganism producing L-threonine having inactivated tyR gene, method of producing the same and method of producing L-threonine using the microorganism

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
COP Corrected version of pamphlet

Free format text: PAGES 1/3-3/3, DRAWINGS, REPLACED BY NEW PAGES 1/3-3/3; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 10466656

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2002578398

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2436366

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002739081

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002739081

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2002739081

Country of ref document: EP