WO2006096392A3 - Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them - Google Patents

Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them Download PDF

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Publication number
WO2006096392A3
WO2006096392A3 PCT/US2006/007136 US2006007136W WO2006096392A3 WO 2006096392 A3 WO2006096392 A3 WO 2006096392A3 US 2006007136 W US2006007136 W US 2006007136W WO 2006096392 A3 WO2006096392 A3 WO 2006096392A3
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WO
WIPO (PCT)
Prior art keywords
astaxanthin
carotenoid
making
methods
biosynthetic pathways
Prior art date
Application number
PCT/US2006/007136
Other languages
French (fr)
Other versions
WO2006096392A2 (en
Inventor
Connie Hansen
Gerhard Frey
Michelle Cayouette
Albert Flavier
Amit Vasavada
Joel Kreps
Original Assignee
Diversa Corp
Connie Hansen
Gerhard Frey
Michelle Cayouette
Albert Flavier
Amit Vasavada
Joel Kreps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diversa Corp, Connie Hansen, Gerhard Frey, Michelle Cayouette, Albert Flavier, Amit Vasavada, Joel Kreps filed Critical Diversa Corp
Publication of WO2006096392A2 publication Critical patent/WO2006096392A2/en
Publication of WO2006096392A3 publication Critical patent/WO2006096392A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Abstract

The invention provides novel enzymes, and the polynucleotides encoding them, involved in carotenoid, astaxanthin and isoprenoid synthesis. The invention also provides novel carotenoid, astaxanthin and isoprenoid biosynthetic pathways comprising at least one enzyme of the invention. The invention also provides novel methods for making carotenoids, astaxanthins and isoprenoids and related compounds using enzymes of the invention. Thus, the invention provides methods for making compounds useful for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
PCT/US2006/007136 2005-03-04 2006-02-28 Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them WO2006096392A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65878005P 2005-03-04 2005-03-04
US60/658,780 2005-03-04

Publications (2)

Publication Number Publication Date
WO2006096392A2 WO2006096392A2 (en) 2006-09-14
WO2006096392A3 true WO2006096392A3 (en) 2007-10-11

Family

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Family Applications (1)

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PCT/US2006/007136 WO2006096392A2 (en) 2005-03-04 2006-02-28 Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them

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WO (1) WO2006096392A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi

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Publication number Priority date Publication date Assignee Title
AU2006227165B2 (en) 2005-03-18 2011-11-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
NZ708078A (en) 2010-06-02 2017-01-27 Evolva Nutrition Inc Recombinant production of steviol glycosides
CA3128532A1 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
CN104540935A (en) 2012-07-18 2015-04-22 耶达研究及发展有限公司 Methods of production of products of metabolic pathways
CA3171770A1 (en) 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
BR112017002783A2 (en) 2014-08-11 2017-12-19 Evolva Sa production of steviol glycosides in recombinant hosts
MY191735A (en) 2014-09-09 2022-07-13 Evolva Sa Production of steviol glycosides in recombinant hosts
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
WO2017025362A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (en) 2016-05-16 2019-02-05 埃沃尔瓦公司 Steviol glycoside is generated in the recombination host
CN110100006A (en) 2016-11-07 2019-08-06 埃沃尔瓦公司 The production of steviol glycoside in recombinant host
CN114835780B (en) * 2022-06-29 2022-09-27 中国农业大学 Oligopeptide MEDEI separated from chilli seeds and application thereof in preventing or treating cancers
CN117264865B (en) * 2023-11-21 2024-03-12 清华大学 Recombinant rhodococcus erythropolis and application thereof in compound synthesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811273A (en) * 1993-12-27 1998-09-22 Kirin Beer Kabushiki Kaisha DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls
US6365386B1 (en) * 1999-03-09 2002-04-02 Roche Vitamins Inc. Astaxanthin synthase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811273A (en) * 1993-12-27 1998-09-22 Kirin Beer Kabushiki Kaisha DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls
US6365386B1 (en) * 1999-03-09 2002-04-02 Roche Vitamins Inc. Astaxanthin synthase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAIRI T. ET AL.: "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin", J. OF BACTERIOLOGY, vol. 183, no. 20, October 2001 (2001-10-01), pages 6085 - 6094 *
LEE ET AL.: "Biosynthesis of structurally novel carotenoids in Escherichia coli", CHEMISTRY & BIOLOGY, vol. 10, May 2003 (2003-05-01), pages 453 - 462, XP026940569, DOI: doi:10.1016/S1074-5521(03)00103-0 *
MISAWA ET AL.: "Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtl in transgenic plants showing an increase of beta-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon", PLANT J., vol. 4, no. 5, 1993, pages 833 - 840, XP002017202, DOI: doi:10.1046/j.1365-313X.1993.04050833.x *
SANDMANN ET AL.: "The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli", TIBTECH, vol. 17, June 1999 (1999-06-01), pages 233 - 237, XP004167255, DOI: doi:10.1016/S0167-7799(99)01307-4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
US9297031B2 (en) 2006-09-28 2016-03-29 Dsm Ip Assets B.V. Production of carotenoids in oleaginous yeast and fungi

Also Published As

Publication number Publication date
WO2006096392A2 (en) 2006-09-14

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