CA2448300A1 - Procede de preparation d'intermediaires de sertraline - Google Patents

Procede de preparation d'intermediaires de sertraline Download PDF

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Publication number
CA2448300A1
CA2448300A1 CA002448300A CA2448300A CA2448300A1 CA 2448300 A1 CA2448300 A1 CA 2448300A1 CA 002448300 A CA002448300 A CA 002448300A CA 2448300 A CA2448300 A CA 2448300A CA 2448300 A1 CA2448300 A1 CA 2448300A1
Authority
CA
Canada
Prior art keywords
dichlorophenyl
dihydro
sertraline
solvent
methanamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002448300A
Other languages
English (en)
Inventor
Ilpo Laitinen
Pekka Pietikaeinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fermion Oy
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI20011146A external-priority patent/FI20011146A0/fi
Application filed by Individual filed Critical Individual
Publication of CA2448300A1 publication Critical patent/CA2448300A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un intermédiaire pharmaceutique, N-[4-(3,4-dichlorophényl)-3,4-dihydro-1(2H)-naphtalénylidène]méthanamine, pouvant être utilisé dans la production d'hydrochlorure de sertraline, et préparé de manière adéquate par réaction de 4-(3,4-dichlorophényl)-3,4-dihydro-1-(2H)-naphtalénone avec de la monométylamine dans un solvant qui est un solvant amide avec une structure de formule générale (IV). Dans cette formule, R1, R3 représentent indépendamment un atome d'hydrogène ou un alkyle en C¿1?-C¿6?, qui peut être substitué, et R2 représente un atome d'hydrogène.
CA002448300A 2001-05-31 2002-05-30 Procede de preparation d'intermediaires de sertraline Abandoned CA2448300A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29426601P 2001-05-31 2001-05-31
FI20011146 2001-05-31
US60/294,266 2001-05-31
FI20011146A FI20011146A0 (fi) 2001-05-31 2001-05-31 Uusi valmistusmenetelmä
PCT/FI2002/000466 WO2002096860A1 (fr) 2001-05-31 2002-05-30 Procede de preparation d'intermediaires de sertraline

Publications (1)

Publication Number Publication Date
CA2448300A1 true CA2448300A1 (fr) 2002-12-05

Family

ID=26161179

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002448300A Abandoned CA2448300A1 (fr) 2001-05-31 2002-05-30 Procede de preparation d'intermediaires de sertraline

Country Status (3)

Country Link
EP (1) EP1397342A1 (fr)
CA (1) CA2448300A1 (fr)
WO (1) WO2002096860A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200808115T1 (tr) * 2006-04-28 2009-03-23 Sandoz Ag 4(S,R)-(3,4-diklorofenil)-3,4-dihidro-l(2H)-naftalin-l-ilid n]metilamin'ın Hazırlanması için Proses.@

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222341B1 (hu) * 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
IN191358B (fr) * 1998-01-16 2003-11-29 Pfizer Prod Inc
YU32700A (sh) * 1999-06-09 2002-03-18 Pfizer Products Inc. Postupak za dobijanje sertralina iz hiralnog tetralona
IN185109B (fr) * 1999-09-01 2000-11-18 Torrent Pharmaceuticals Ltd
HUP0203384A3 (en) * 1999-11-16 2006-02-28 Ciba Sc Holding Ag Process for the preparation of ketimines
PT1230212E (pt) * 1999-11-16 2005-08-31 Ciba Sc Holding Ag Metodo de embalar elementos de construcao de brinquedo
ES2281374T3 (es) * 1999-12-21 2007-10-01 Teva Pharmaceutical Industries Ltd. Nuevos polimorfos de hidrocloruro de sertralina, procedimientos para su preparacion, composiciones que los contienen y metodos para su utilizacion.

Also Published As

Publication number Publication date
WO2002096860A1 (fr) 2002-12-05
EP1397342A1 (fr) 2004-03-17

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Legal Events

Date Code Title Description
FZDE Dead