CA2447052A1 - Combined approach to treatment of cancer using a c-myc antisense oligomer - Google Patents
Combined approach to treatment of cancer using a c-myc antisense oligomer Download PDFInfo
- Publication number
- CA2447052A1 CA2447052A1 CA002447052A CA2447052A CA2447052A1 CA 2447052 A1 CA2447052 A1 CA 2447052A1 CA 002447052 A CA002447052 A CA 002447052A CA 2447052 A CA2447052 A CA 2447052A CA 2447052 A1 CA2447052 A1 CA 2447052A1
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- CA
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- Prior art keywords
- antisense
- myc
- oligomer
- seq
- cancer
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US29172701P | 2001-05-17 | 2001-05-17 | |
| US60/291,727 | 2001-05-17 | ||
| PCT/US2002/015842 WO2002092617A1 (en) | 2001-05-17 | 2002-05-17 | Combined approach to treatment of cancer using a c-myc antisense oligomer |
Publications (1)
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| CA2447052A1 true CA2447052A1 (en) | 2002-11-21 |
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| CA002447052A Abandoned CA2447052A1 (en) | 2001-05-17 | 2002-05-17 | Combined approach to treatment of cancer using a c-myc antisense oligomer |
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| Country | Link |
|---|---|
| US (1) | US20030087861A1 (https=) |
| EP (1) | EP1399462A4 (https=) |
| JP (1) | JP2004537517A (https=) |
| KR (1) | KR20040004629A (https=) |
| CN (1) | CN1509292A (https=) |
| CA (1) | CA2447052A1 (https=) |
| NZ (1) | NZ530101A (https=) |
| WO (1) | WO2002092617A1 (https=) |
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| US7640582B2 (en) | 2003-04-16 | 2009-12-29 | Silicon Graphics International | Clustered filesystem for mix of trusted and untrusted nodes |
| CA2523672C (en) * | 2003-04-29 | 2012-07-17 | Avi Biopharma, Inc. | Compositions for enhancing transport of molecules into cells |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| WO2006058038A2 (en) * | 2004-11-22 | 2006-06-01 | The Research Foundation Of State University Of New York At Buffalo | In vitro and in vivo silencing of human c-myc oncogene expression by poly-dnp-rna |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| WO2007065017A2 (en) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Oligonucleotide cationic liposomal delivery system |
| CA2631677C (en) | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| EP1971371B1 (en) * | 2005-12-01 | 2015-08-05 | Pronai Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
| US20070270371A1 (en) * | 2006-03-31 | 2007-11-22 | Brown Bob D | Dosing and scheduling of oligomers |
| DK2735568T3 (da) * | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| EP3443976A1 (en) * | 2007-06-29 | 2019-02-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| CN101624596B (zh) * | 2009-08-12 | 2011-01-26 | 广州金琪基因技术研究发展中心 | 一种靶向c-myc癌基因的外指引序列 |
| KR20200133284A (ko) | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| EA202090338A1 (ru) | 2011-11-18 | 2021-04-30 | Сарепта Терапьютикс, Инк. | Функционально-модифицированные олигонуклеотиды и их субъединицы |
| ITMI20120275A1 (it) * | 2012-02-24 | 2013-08-25 | Biogenera Societa A Responsabilita Limitata | Oligonucleotidi per la modulazione dell'espressione genica e loro usi |
| KR102192591B1 (ko) * | 2013-09-09 | 2020-12-18 | 삼성전자주식회사 | c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물 |
| WO2016048054A2 (ko) * | 2014-09-24 | 2016-03-31 | 삼성전자 주식회사 | 데이터 통신 보안을 위한 방법, 장치 및 시스템 |
| EP3302489A4 (en) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES |
| SMT202200366T1 (it) | 2016-12-19 | 2022-11-18 | Sarepta Therapeutics Inc | Coniugati di oligomeri per salto di esone per distrofia muscolare |
| CN108338986B (zh) * | 2017-01-23 | 2020-04-03 | 深圳开悦生命科技有限公司 | 一种用于治疗癌症的小分子rna及其应用 |
| EP3790890A4 (en) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC, CELL-PENETRATING PEPTIDES WITH ONE OR MORE HYDROPHOBIC RAILS |
| EP3840758A1 (en) * | 2018-08-21 | 2021-06-30 | Deep Genomics Incorporated | Therapeutic splice-switching oligonucleotides |
| CA3126432A1 (en) * | 2019-02-01 | 2020-08-06 | Health Research, Inc. | Methods and compositions for treating resistant and recurrent forms of cancer |
| KR20210134003A (ko) | 2019-02-27 | 2021-11-08 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 안티센스 올리고머 |
| BR112022022889A2 (pt) | 2020-05-11 | 2023-04-04 | Stoke Therapeutics Inc | Oligômeros antissentido de opa1 para tratamento de condições e doenças |
| US12378267B2 (en) | 2021-06-17 | 2025-08-05 | Entrada Therapeutics, Inc. | Synthesis of FMOC-protected morpholino monomers and oligomers |
| US20250289851A1 (en) | 2022-04-22 | 2025-09-18 | Entrada Therapeutics, Inc. | Cyclic peptides for delivering therapeutics |
| EP4665407A2 (en) * | 2023-02-14 | 2025-12-24 | Stoke Therapeutics, Inc. | Antisense oligomer formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515781A (en) * | 1983-02-23 | 1985-05-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 2',5'-Riboadenylate-morpholinoadenylate nucleotides |
| US6544755B1 (en) * | 1992-08-26 | 2003-04-08 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of diseases by expression of the c-Myc gene |
| ATE208634T1 (de) * | 1993-01-07 | 2001-11-15 | Univ Jefferson | Modulation der proliferation von glatten muskelzellen durch antisense inhibition von c-myc |
| EP0932698A1 (en) * | 1996-03-26 | 1999-08-04 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
| US6784291B2 (en) * | 2000-05-04 | 2004-08-31 | Avi Biopharma, Inc. | Splice-region antisense composition and method |
-
2002
- 2002-05-17 JP JP2002589500A patent/JP2004537517A/ja active Pending
- 2002-05-17 US US10/151,008 patent/US20030087861A1/en not_active Abandoned
- 2002-05-17 KR KR10-2003-7014985A patent/KR20040004629A/ko not_active Ceased
- 2002-05-17 NZ NZ530101A patent/NZ530101A/en unknown
- 2002-05-17 EP EP02769769A patent/EP1399462A4/en not_active Withdrawn
- 2002-05-17 WO PCT/US2002/015842 patent/WO2002092617A1/en not_active Ceased
- 2002-05-17 CA CA002447052A patent/CA2447052A1/en not_active Abandoned
- 2002-05-17 CN CNA028100719A patent/CN1509292A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1399462A4 (en) | 2008-03-05 |
| NZ530101A (en) | 2007-01-26 |
| KR20040004629A (ko) | 2004-01-13 |
| US20030087861A1 (en) | 2003-05-08 |
| CN1509292A (zh) | 2004-06-30 |
| EP1399462A1 (en) | 2004-03-24 |
| WO2002092617A1 (en) | 2002-11-21 |
| JP2004537517A (ja) | 2004-12-16 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |