CA2446991A1 - Agents that regulate apoptosis - Google Patents

Agents that regulate apoptosis Download PDF

Info

Publication number
CA2446991A1
CA2446991A1 CA002446991A CA2446991A CA2446991A1 CA 2446991 A1 CA2446991 A1 CA 2446991A1 CA 002446991 A CA002446991 A CA 002446991A CA 2446991 A CA2446991 A CA 2446991A CA 2446991 A1 CA2446991 A1 CA 2446991A1
Authority
CA
Canada
Prior art keywords
seq
leu
ser
glu
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002446991A
Other languages
English (en)
French (fr)
Inventor
Richard Tritz
Benjamin Keily
Cellia Habita
Joan Robbins
Jack Barber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immusol Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2446991A1 publication Critical patent/CA2446991A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002446991A 2001-05-14 2002-05-14 Agents that regulate apoptosis Abandoned CA2446991A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29092701P 2001-05-14 2001-05-14
US60/290,927 2001-05-14
PCT/US2002/015198 WO2002092840A2 (en) 2001-05-14 2002-05-14 Agents that regulate apoptosis

Publications (1)

Publication Number Publication Date
CA2446991A1 true CA2446991A1 (en) 2002-11-21

Family

ID=23118085

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002446991A Abandoned CA2446991A1 (en) 2001-05-14 2002-05-14 Agents that regulate apoptosis

Country Status (6)

Country Link
US (1) US20040248830A1 (enExample)
EP (1) EP1474175A4 (enExample)
JP (1) JP2005501524A (enExample)
AU (1) AU2002314780A1 (enExample)
CA (1) CA2446991A1 (enExample)
WO (1) WO2002092840A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1677739A4 (en) * 2003-09-04 2008-07-23 Immusol Inc METHODS FOR IDENTIFYING AGENTS THAT INHIBIT THE GROWTH OF CANCER CELLS
US8012948B2 (en) * 2008-10-15 2011-09-06 Promising Future, Llc Fas/FasL or other death receptor targeted methods and compositions for killing tumor cells
WO2011129371A1 (ja) * 2010-04-14 2011-10-20 国立大学法人鳥取大学 ５－ＦＵ単独及びＩＦＮ－α／５－ＦＵ併用時の抗腫瘍効果を増強する遺伝子群

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0996741A4 (en) * 1997-01-23 2004-06-09 Immusol Inc FUNCTIONAL ANALYSIS AND GENE DISCOVERY USING TARGET SPECIFIC RIBOZY VECTOR BANKS OR WELL MADE RANDOM

Also Published As

Publication number Publication date
AU2002314780A1 (en) 2002-11-25
US20040248830A1 (en) 2004-12-09
EP1474175A2 (en) 2004-11-10
EP1474175A4 (en) 2005-01-19
WO2002092840A3 (en) 2004-09-10
WO2002092840A2 (en) 2002-11-21
JP2005501524A (ja) 2005-01-20

Similar Documents

Publication Publication Date Title
AU2017235661B2 (en) Oligonucleotide probes and uses thereof
KR101914309B1 (ko) 전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
WO1999033963A1 (en) Metastatic cancer regulated gene
WO2010120262A1 (en) Methods and compositions for the treatment of medical conditions involving cellular programming
JP2013515459A (ja) 膜結合転写因子ペプチダーゼ、部位１（ｍｂｔｐｓ１）に対する天然アンチセンス転写物の阻害によるｍｂｔｐｓ１関連性疾患の治療
WO2001009311A9 (en) Methods of inhibiting cancer cells with adnf iii antisense oligonucleotides
KR20200081380A (ko) 유전적 조절
JP2002525081A (ja) 低酸素により調節される遺伝子転写に特徴的な配列
WO1995022612A2 (en) Genes and genetic elements associated with sensitivity to platinum-based drugs
EP0694068B1 (en) Genetic suppressor elements associated with sensitivity to chemotherapeutic drugs
CA2446991A1 (en) Agents that regulate apoptosis
Wong-Riley et al. Human COX6A1 gene: promoter analysis, cDNA isolation and expression in the monkey brain
US6537754B1 (en) Association of kinesin with sensitivity to chemotherapeutic drugs
US20050186212A1 (en) Trefoil factor 3 (TFF3) as a target for anti-cancer therapy
KR20210091197A (ko) Foxp3 발현의 조절인자
AU689840B2 (en) Association of kinesin with sensitivity to chemotherapeutic drugs
US6982313B2 (en) Genes and genetic elements associated with sensitivity to chemotherapeutic drugs
CA2445423A1 (en) Fusion genes associated with acute megakaryoblastic leukemias
CA2343354A1 (en) Inhibitor of brn-3b and its use for the treatment of breast and ovarian cancer
JP4723133B2 (ja) 新規ヒトｂｍｃｃ１遺伝子
WO1998000695A2 (en) Tat-sf: cofactor for stimulation of transcriptional elongation by hiv-1 tat
US20020182694A1 (en) Novel gene and polypeptide which opposes the Fas pathway
US6787646B1 (en) Tumor suppressor molecules and methods of use
US20040002097A1 (en) Association of kinesin with sensitivity to chemotherapeutic drugs
JP2003527860A (ja) Ｂｒｃａ−１制御因子およびその使用方法

Legal Events

Date Code Title Description
FZDE Discontinued