CA2435283A1 - Procede relatif a l'identification de composes modulant la separation des chromatides jumeaux - Google Patents

Procede relatif a l'identification de composes modulant la separation des chromatides jumeaux Download PDF

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Publication number
CA2435283A1
CA2435283A1 CA002435283A CA2435283A CA2435283A1 CA 2435283 A1 CA2435283 A1 CA 2435283A1 CA 002435283 A CA002435283 A CA 002435283A CA 2435283 A CA2435283 A CA 2435283A CA 2435283 A1 CA2435283 A1 CA 2435283A1
Authority
CA
Canada
Prior art keywords
leu
separase
ala
ser
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002435283A
Other languages
English (en)
Inventor
Jan-Michael Peters
Irene Waizenegger
Wolfgang Sommergruber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2435283A1 publication Critical patent/CA2435283A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés de criblage qui assurent l'identification d'inhibiteurs de séparase, compte tenu des formes actives de séparase. L'invention concerne également des composés identifiés par le biais de ces procédés.
CA002435283A 2001-01-19 2002-01-19 Procede relatif a l'identification de composes modulant la separation des chromatides jumeaux Abandoned CA2435283A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01101252A EP1227160A1 (fr) 2001-01-19 2001-01-19 Des composés qui influent la séparation des chromatides soeurs ainsi qu'une méthode pour les identifier
EP01101252.3 2001-01-19
PCT/EP2002/000529 WO2002057566A2 (fr) 2001-01-19 2002-01-19 Procede relatif a l'identification de composes modulant la separation des chromatides jumeaux

Publications (1)

Publication Number Publication Date
CA2435283A1 true CA2435283A1 (fr) 2002-07-25

Family

ID=8176255

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002435283A Abandoned CA2435283A1 (fr) 2001-01-19 2002-01-19 Procede relatif a l'identification de composes modulant la separation des chromatides jumeaux

Country Status (4)

Country Link
EP (2) EP1227160A1 (fr)
AU (1) AU2002237281A1 (fr)
CA (1) CA2435283A1 (fr)
WO (1) WO2002057566A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
EP1029547A1 (fr) * 1999-02-15 2000-08-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Composés pharmaceutiques actifs et procedé pour les identifiér
US20020039776A1 (en) 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
US10174359B2 (en) 2012-07-11 2019-01-08 Japanese Foundation For Cancer Research Fluorescent separase activity sensor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8902010A (nl) * 1989-08-04 1991-03-01 Nl Zuivelonderzoek Inst Dna-fragment met ten minste een protease-gen, een dergelijk dna-fragment bevattende cloneringsvektor, een gastheercel getransformeerd met een dusdanig opgebouwde cloneringsvektor, alsmede de met dergelijke gastheercellen geproduceerde proteasen resp. bereide produkten zoals voedingsmiddelen.
US5766609A (en) * 1991-12-13 1998-06-16 Heska Corporation Use of protease inhibitors and protease vaccines to protect animals from flea infestation
JPH08196279A (ja) * 1995-01-25 1996-08-06 Mitsui Toatsu Chem Inc 蛋白質及びその遺伝子
EP1029547A1 (fr) * 1999-02-15 2000-08-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Composés pharmaceutiques actifs et procedé pour les identifiér
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides

Also Published As

Publication number Publication date
AU2002237281A1 (en) 2002-07-30
EP1414992A2 (fr) 2004-05-06
EP1227160A1 (fr) 2002-07-31
WO2002057566A3 (fr) 2004-02-19
WO2002057566A2 (fr) 2002-07-25

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued