CA2429724A1 - Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes - Google Patents

Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes Download PDF

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Publication number
CA2429724A1
CA2429724A1 CA002429724A CA2429724A CA2429724A1 CA 2429724 A1 CA2429724 A1 CA 2429724A1 CA 002429724 A CA002429724 A CA 002429724A CA 2429724 A CA2429724 A CA 2429724A CA 2429724 A1 CA2429724 A1 CA 2429724A1
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CA
Canada
Prior art keywords
methods
artificial chromosomes
chromosomes
preparing
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002429724A
Other languages
French (fr)
Other versions
CA2429724C (en
Inventor
Gyula Hadlaczky
Aladar A. Szalay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Hungarian Academy of Sciences Biologic Research Center
Original Assignee
Chromos Molecular Systems Inc.
Gyula Hadlaczky
Aladar A. Szalay
The Biological Research Center Of The Hungarian Academy Of Sciences
Loma Linda University
American Gene Therapy, Inc.
Chromos Molecular Systems, Inc.
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/682,080 external-priority patent/US6077697A/en
Priority claimed from US08/695,191 external-priority patent/US6025155A/en
Application filed by Chromos Molecular Systems Inc., Gyula Hadlaczky, Aladar A. Szalay, The Biological Research Center Of The Hungarian Academy Of Sciences, Loma Linda University, American Gene Therapy, Inc., Chromos Molecular Systems, Inc., Glaxo Group Limited filed Critical Chromos Molecular Systems Inc.
Publication of CA2429724A1 publication Critical patent/CA2429724A1/en
Application granted granted Critical
Publication of CA2429724C publication Critical patent/CA2429724C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods for preparing cell fines that contain artificial chromosomes, methods for preparation of artifcial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin, are provided. Methods for use of the artificial chromosomes, including f~r gene therapy, production of gene products and production of transgenic plants and animals are also provided.
CA002429724A 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes Expired - Lifetime CA2429724C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US62982296A 1996-04-10 1996-04-10
US629,822 1996-04-10
US682,080 1996-07-15
US08/682,080 US6077697A (en) 1996-04-10 1996-07-15 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US695,191 1996-08-07
US08/695,191 US6025155A (en) 1996-04-10 1996-08-07 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
CA002250682A CA2250682C (en) 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002250682A Division CA2250682C (en) 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Publications (2)

Publication Number Publication Date
CA2429724A1 true CA2429724A1 (en) 1997-10-30
CA2429724C CA2429724C (en) 2005-10-25

Family

ID=27670700

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002429724A Expired - Lifetime CA2429724C (en) 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
CA002429726A Abandoned CA2429726A1 (en) 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002429726A Abandoned CA2429726A1 (en) 1996-04-10 1997-04-10 Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Country Status (1)

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CA (2) CA2429724C (en)

Also Published As

Publication number Publication date
CA2429726A1 (en) 1997-10-30
CA2429724C (en) 2005-10-25

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Effective date: 20170410