CA2422440C - Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis - Google Patents

Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis Download PDF

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Publication number
CA2422440C
CA2422440C CA2422440A CA2422440A CA2422440C CA 2422440 C CA2422440 C CA 2422440C CA 2422440 A CA2422440 A CA 2422440A CA 2422440 A CA2422440 A CA 2422440A CA 2422440 C CA2422440 C CA 2422440C
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CA
Canada
Prior art keywords
probe
oligonucleotide probe
seq
dna
artificial sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2422440A
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English (en)
French (fr)
Other versions
CA2422440A1 (en
Inventor
Joseph G. Utermohlen
John Connaughton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems Inc filed Critical Ventana Medical Systems Inc
Priority to CA2703141A priority Critical patent/CA2703141C/en
Publication of CA2422440A1 publication Critical patent/CA2422440A1/en
Application granted granted Critical
Publication of CA2422440C publication Critical patent/CA2422440C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2422440A 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis Expired - Lifetime CA2422440C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2703141A CA2703141C (en) 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23317700P 2000-09-15 2000-09-15
US60/233,177 2000-09-15
PCT/US2001/028014 WO2002022874A2 (en) 2000-09-15 2001-09-06 Oligonucleotides for labeling oligonucleotide probes and proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2703141A Division CA2703141C (en) 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis

Publications (2)

Publication Number Publication Date
CA2422440A1 CA2422440A1 (en) 2002-03-21
CA2422440C true CA2422440C (en) 2010-07-27

Family

ID=22876207

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2422440A Expired - Lifetime CA2422440C (en) 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis
CA2703141A Expired - Lifetime CA2703141C (en) 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2703141A Expired - Lifetime CA2703141C (en) 2000-09-15 2001-09-06 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis

Country Status (10)

Country Link
US (3) US7838655B2 (https=)
EP (1) EP1366187B1 (https=)
JP (2) JP4986367B2 (https=)
AT (1) ATE415491T1 (https=)
AU (2) AU9454201A (https=)
CA (2) CA2422440C (https=)
DE (1) DE60136746D1 (https=)
DK (1) DK1366187T3 (https=)
ES (1) ES2317939T3 (https=)
WO (1) WO2002022874A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838655B2 (en) 2000-09-15 2010-11-23 Ventana Medical Systems, Inc. Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis
AU2002309423B2 (en) * 2001-06-06 2007-11-22 Fujirebio Diagnostics Ab Method to measure gene expression ratio of key genes
US8574836B2 (en) * 2005-01-12 2013-11-05 Ramesh Vallabhaneni Method and apparatus for chromosome profiling
JP5588970B2 (ja) 2008-05-27 2014-09-10 ダコ・デンマーク・エー／エス ハイブリダイゼーション組成物及び方法
US9896720B2 (en) 2008-09-10 2018-02-20 Rutgers, The State University Of New Jersey Imaging individual mRNA molecules using multiple singly labeled probes
US9303287B2 (en) 2009-02-26 2016-04-05 Dako Denmark A/S Compositions and methods for RNA hybridization applications
EP2443254A2 (en) * 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
CN112424825B (zh) 2018-05-15 2025-01-07 文塔纳医疗系统公司 染色聚集体中信号的定量
KR20220160633A (ko) * 2020-03-31 2022-12-06 퍼스널 게놈 다이아그노스틱스 인코포레이티드 핵산 품질 결정을 위한 조성물 및 방법
CN115948608A (zh) * 2022-08-05 2023-04-11 北京中杉金桥生物技术有限公司 一种用于eber检测的探针组及试剂盒

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948922A (en) * 1973-01-02 1976-04-06 Lowe Orville G Oxidation of thiols and disulfides to sulfonic acids
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5489507A (en) * 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
US5789161A (en) * 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
US5843660A (en) * 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
US5684142A (en) * 1995-06-07 1997-11-04 Oncor, Inc. Modified nucleotides for nucleic acid labeling
US5871917A (en) * 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US7504493B2 (en) * 1997-01-23 2009-03-17 The John Hopkins University Characterization of the yeast transcriptome
US7838655B2 (en) * 2000-09-15 2010-11-23 Ventana Medical Systems, Inc. Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis
US7399339B2 (en) * 2005-06-15 2008-07-15 Gas Technology Institute Polyoxometalate material for gaseous stream purification at high temperature

Also Published As

Publication number Publication date
CA2703141A1 (en) 2002-03-21
DK1366187T3 (da) 2009-02-16
ATE415491T1 (de) 2008-12-15
CA2422440A1 (en) 2002-03-21
AU2001294542B8 (en) 2008-07-03
US7838655B2 (en) 2010-11-23
WO2002022874A8 (en) 2003-07-10
AU2001294542B2 (en) 2008-04-03
CA2703141C (en) 2014-10-21
US20120309951A1 (en) 2012-12-06
US20040014088A1 (en) 2004-01-22
US8524877B2 (en) 2013-09-03
JP2005503753A (ja) 2005-02-10
ES2317939T3 (es) 2009-05-01
AU9454201A (en) 2002-03-26
US8236502B2 (en) 2012-08-07
JP5272063B2 (ja) 2013-08-28
JP4986367B2 (ja) 2012-07-25
EP1366187A2 (en) 2003-12-03
WO2002022874A9 (en) 2003-04-03
US20110034682A1 (en) 2011-02-10
WO2002022874A2 (en) 2002-03-21
DE60136746D1 (de) 2009-01-08
EP1366187B1 (en) 2008-11-26
JP2012065660A (ja) 2012-04-05
WO2002022874A3 (en) 2003-09-25

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