CA2420932A1 - Nouveau recepteur nucleaire de mammifere l66 et ses methodes d'utilisation - Google Patents

Nouveau recepteur nucleaire de mammifere l66 et ses methodes d'utilisation Download PDF

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Publication number
CA2420932A1
CA2420932A1 CA002420932A CA2420932A CA2420932A1 CA 2420932 A1 CA2420932 A1 CA 2420932A1 CA 002420932 A CA002420932 A CA 002420932A CA 2420932 A CA2420932 A CA 2420932A CA 2420932 A1 CA2420932 A1 CA 2420932A1
Authority
CA
Canada
Prior art keywords
nucleic acid
receptor
sequence
leu
nuclear receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420932A
Other languages
English (en)
Inventor
Georg Casari
Michael Hofer
David Jackson
Harald Kranz
Kerstin Otte
Bettina Remmel
Jorg Suckow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sygnis Pharma AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420932A1 publication Critical patent/CA2420932A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un nouveau récepteur nucléaire appelé <= L66 >= ou également FXR-.beta., un homologue de FXR-.alpha., un prototype de récepteur nucléaire de type 2. L'invention concerne également la séquence d'acide nucléique isolée de L66 et la protéine isolée liée à la séquence d'acide nucléique isolée. L'invention concerne également des procédés permettant d'isoler et/ou de produire cet acide nucléique ou cette protéine, ainsi que des méthodes d'utilisation de ce récepteur L66.
CA002420932A 2000-09-16 2001-09-07 Nouveau recepteur nucleaire de mammifere l66 et ses methodes d'utilisation Abandoned CA2420932A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP00120370 2000-09-16
EP00120370.2 2000-09-16
EP01111658.9 2001-05-14
EP01111658 2001-05-14
PCT/EP2001/010323 WO2002022817A2 (fr) 2000-09-16 2001-09-07 Nouveau recepteur nucleaire de mammifere l66 et ses methodes d'utilisation

Publications (1)

Publication Number Publication Date
CA2420932A1 true CA2420932A1 (fr) 2002-03-21

Family

ID=26071406

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420932A Abandoned CA2420932A1 (fr) 2000-09-16 2001-09-07 Nouveau recepteur nucleaire de mammifere l66 et ses methodes d'utilisation

Country Status (4)

Country Link
EP (1) EP1317542A2 (fr)
AU (1) AU2002213893A1 (fr)
CA (1) CA2420932A1 (fr)
WO (1) WO2002022817A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109467A1 (en) * 2001-11-15 2003-06-12 Isis Pharmaceuticals Inc. Antisense modulation of human FXR expression
AU2003219028A1 (en) * 2002-04-13 2003-10-27 Lion Bioscience Ag NON-PRIMATE FXRb AS A LANOSTEROL SENSING NUCLEAR HORMONE RECEPTOR AND RELATED USES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932699A (en) * 1995-01-13 1999-08-03 The General Hospital Corporation Retinoid X receptor-interacting polypeptides
US6005086A (en) * 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
US5728548A (en) * 1995-06-29 1998-03-17 Genetics Institute, Inc. Retinoid receptor-1 (RR1) and DNA encoding RR1
AU780658B2 (en) * 1999-03-26 2005-04-07 City Of Hope Method of affecting cholesterol catabolism using nuclear bile acid receptor

Also Published As

Publication number Publication date
WO2002022817A2 (fr) 2002-03-21
AU2002213893A1 (en) 2002-03-26
EP1317542A2 (fr) 2003-06-11
WO2002022817A3 (fr) 2003-03-27

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Legal Events

Date Code Title Description
FZDE Dead