CA2416698A1 - Films d'hydrogel et procedes de fabrication et d'utilisation de ces films - Google Patents

Films d'hydrogel et procedes de fabrication et d'utilisation de ces films Download PDF

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Publication number
CA2416698A1
CA2416698A1 CA002416698A CA2416698A CA2416698A1 CA 2416698 A1 CA2416698 A1 CA 2416698A1 CA 002416698 A CA002416698 A CA 002416698A CA 2416698 A CA2416698 A CA 2416698A CA 2416698 A1 CA2416698 A1 CA 2416698A1
Authority
CA
Canada
Prior art keywords
film
hydrogel
wound
films
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002416698A
Other languages
English (en)
Inventor
Kelly R. Kirker
Glenn D. Prestwich
Yi Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2416698A1 publication Critical patent/CA2416698A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/336—Polymers modified by chemical after-treatment with organic compounds containing silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C08G65/005—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens
    • C08G65/007—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens containing fluorine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Cette invention se rapporte à des films d'hydrogel améliorés utiles dans des traitements thérapeutiques. Cette invention concerne également des matières et des procédés servant à modifier et à polymériser des polysaccharides en films d'hydrogel qui gonflent après exposition à une solution aqueuse neutre. Ces procédés peuvent consister à modifier un polysaccharide ayant au moins un groupe acide carboxylique en un dérivé dihydrazide de polysaccharide, lequel est ensuite réticulé avec un polyaldéhyde pour créer un film d'hydrogel. Cette invention concerne également des compositions pharmaceutiques constituées par un composé pharmaceutiquement acceptable et par un film d'hydrogel décrit ci-dessus. Cette invention concerne en outre l'utilisation de ces films d'hydrogels et de ces compositions pharmaceutiques.
CA002416698A 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films Abandoned CA2416698A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21872500P 2000-07-17 2000-07-17
US60/218,725 2000-07-17
PCT/US2001/022556 WO2002006373A1 (fr) 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films

Publications (1)

Publication Number Publication Date
CA2416698A1 true CA2416698A1 (fr) 2002-01-24

Family

ID=22816250

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416698A Abandoned CA2416698A1 (fr) 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films

Country Status (4)

Country Link
EP (1) EP1305355A1 (fr)
AU (1) AU2001278943A1 (fr)
CA (1) CA2416698A1 (fr)
WO (1) WO2002006373A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1465596A1 (fr) * 2002-01-18 2004-10-13 Control Delivery Systems, Inc. Systeme de gel polymere pour administration regulee de medicaments combines
ES2449017T3 (es) 2002-06-21 2014-03-17 The University Of Utah Research Foundation Compuestos reticulados, y métodos de preparación y uso de los mismos
JPWO2004050712A1 (ja) * 2002-11-29 2006-03-30 中外製薬株式会社 薬物徐放担体
US8324184B2 (en) 2003-05-15 2012-12-04 University Of Utah Research Foundation Anti-adhesion composites and methods of use thereof
CA2549295C (fr) * 2003-12-04 2016-05-03 University Of Utah Research Foundation Macromolecules modifiees et procedes de production et d'utilisation associes
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
CA2574086A1 (fr) 2004-07-21 2006-02-23 Medtronic, Inc. Appareils medicaux et methodes de reduction de fibroses localisees
WO2006085329A2 (fr) * 2005-02-14 2006-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Hydrogel adhesif depolymerise a base de polysaccharide, et son procede d'utilisation
ATE494308T1 (de) * 2005-11-22 2011-01-15 Centre Nat Rech Scient Neue derivate von hyaluronsäure, herstellungsverfahren dafür und verwendungen davon
WO2007120818A2 (fr) * 2006-04-12 2007-10-25 Massachusetts Institute Of Technology Compositions et méthodes permettant d'inhiber les adhérences
EP1897543A1 (fr) 2006-08-30 2008-03-12 Euro-Celtique S.A. Gaufre de buprénorphine pour la thérapie de substitution
DE102008005172A1 (de) * 2008-01-19 2009-07-23 Mike Ehrlich Pharmazeutische Zusammensetzung zur Verhinderung von post-operativen Adhäsionen
EP2247718B1 (fr) 2008-01-30 2019-01-16 Asterias Biotherapeutics, Inc. Surfaces synthétiques pour la culture de cardiomyocytes issus de cellules souches
KR101635750B1 (ko) 2008-01-30 2016-07-04 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 올리고덴드로사이트 전구 세포를 배양하기 위한 합성 표면
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
US8168433B2 (en) 2008-01-30 2012-05-01 Corning Incorporated Cell culture article and screening
CA2722425A1 (fr) 2008-04-28 2009-11-05 Surmodics, Inc. Matrices a base de poly-.alpha.(1-4)glucopyranose reticulees avec un hydrazide
US8932622B2 (en) 2008-06-03 2015-01-13 Actamax Surgical Materials, Llc Tissue coating for preventing undesired tissue-to-tissue adhesions
US20130085571A1 (en) * 2009-05-14 2013-04-04 Anja Mueller Composition and method of preparation of polysaccharide gel-based artificial, biodegradable skin scaffolds
WO2010138074A1 (fr) * 2009-05-29 2010-12-02 Hilborn Joens Systèmes d'administration à base d'acide hyaluronique
FR2972113A1 (fr) * 2011-03-02 2012-09-07 Philippe Zanchetta Utilisation d'un melange de polysaccharides specifiques comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation cutanee
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
CA3125761A1 (fr) * 2019-01-30 2020-08-06 Bausch & Lomb Incorporated Reseau polymere reticule et son utilisation
CN110894302A (zh) * 2019-11-19 2020-03-20 福建医科大学孟超肝胆医院(福州市传染病医院) 一种基于亚胺键和酰腙键的抗菌水凝胶及其制备方法
CN113024845A (zh) * 2021-03-17 2021-06-25 广西医科大学 一种醛肼交联型抗菌水凝胶敷料的制备方法
CN114044548B (zh) * 2021-09-24 2023-08-11 杭州食疗晶元生物科技有限公司 一种快速降解水凝胶回收水资源的方法
CN114404648A (zh) * 2022-01-18 2022-04-29 张培华 促进糖尿病创面修复可降解抗菌止血水凝胶的制备方法
CN114486838B (zh) * 2022-02-18 2024-03-15 吉林大学 一种四环素类抗生素的检测方法

Family Cites Families (3)

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SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US6180288B1 (en) * 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof

Also Published As

Publication number Publication date
AU2001278943A1 (en) 2002-01-30
WO2002006373A1 (fr) 2002-01-24
EP1305355A1 (fr) 2003-05-02

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Legal Events

Date Code Title Description
FZDE Discontinued