CA2410754A1 - Polypeptides phosphoryles et utilisations correspondantes - Google Patents

Polypeptides phosphoryles et utilisations correspondantes Download PDF

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Publication number
CA2410754A1
CA2410754A1 CA002410754A CA2410754A CA2410754A1 CA 2410754 A1 CA2410754 A1 CA 2410754A1 CA 002410754 A CA002410754 A CA 002410754A CA 2410754 A CA2410754 A CA 2410754A CA 2410754 A1 CA2410754 A1 CA 2410754A1
Authority
CA
Canada
Prior art keywords
mab
polypeptide
chcc49
mabs
phosphorylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002410754A
Other languages
English (en)
Inventor
Sidney Pestka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pestka Biomedical Laboratories Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2410754A1 publication Critical patent/CA2410754A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention se rapporte à des procédés servant à produire des polypeptides modifiés, des anticorps modifiés, des polypeptides modifiés phosphorylés de façon stable, des anticorps modifiés phosphorylés de façon stable, des séquences de polynucléotides codant ces polypeptides, ainsi qu'à des utilisations de ces composés. Cette invention concerne également un procédé de modélisation moléculaire assisté par ordinateur, destiné à produire des polypeptides phosphorylables modifiés, des anticorps particulièrement monoclonaux (MAb) à utiliser dans le diagnostic et le traitement de cancers et d'autres maladies. Les MAb correspondants contiennent des sites de reconnaissance hétérologues pour les polypeptide-kinases et ils peuvent être marqués par un marqueur identifiable, tel que le radio-isotope ?32¿P. Le ou les groupes phosphate fixés au polypeptide phosphorylé sont inhabituellement stables en raison des interactions intramoléculaires génétiquement modifiées entre le groupe phosphate et ses groupes voisins. Cette invention concerne en outre des séquences de polynucléotides qui codent un anticorps monoclonal contenant des séquences codant un site de phosphorylation présumé, ainsi que des procédés servant à analyser les propriétés biochimiques d'un polypeptide en utilisant des outils de modélisation moléculaire.
CA002410754A 2000-05-31 2001-05-31 Polypeptides phosphoryles et utilisations correspondantes Abandoned CA2410754A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20824000P 2000-05-31 2000-05-31
US60/208,240 2000-05-31
US25529900P 2000-12-13 2000-12-13
US60/255,296 2000-12-13
PCT/US2001/017935 WO2001092469A2 (fr) 2000-05-31 2001-05-31 Polypeptides phosphoryles et utilisations correspondantes

Publications (1)

Publication Number Publication Date
CA2410754A1 true CA2410754A1 (fr) 2001-12-06

Family

ID=26903029

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002410754A Abandoned CA2410754A1 (fr) 2000-05-31 2001-05-31 Polypeptides phosphoryles et utilisations correspondantes

Country Status (5)

Country Link
EP (1) EP1299327A4 (fr)
JP (1) JP2003534790A (fr)
AU (2) AU2001265343B2 (fr)
CA (1) CA2410754A1 (fr)
WO (1) WO2001092469A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050064507A1 (en) * 2003-09-11 2005-03-24 James Stephen Shaw Determining kinase specificity
JP5344391B2 (ja) * 2009-02-23 2013-11-20 国立大学法人北陸先端科学技術大学院大学 タンパク質分子の分子模型及びその作製方法
CN105188728B (zh) 2013-05-07 2021-11-09 默克专利股份有限公司 用于肾靶向的肽和肽-活性物质-缀合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923802A (en) * 1985-06-13 1990-05-08 Immunex Corporation Peptide substrates for the detection, characterization and purification of protein kinase C
IL92124A (en) * 1988-10-28 1996-10-31 Sidney Pestka Recombinant proteins modified to contain post-phosphorylation that do not occur in nature
US5986061A (en) * 1988-10-28 1999-11-16 Pbl Biomedical Laboratories Phosphorylated fusion proteins

Also Published As

Publication number Publication date
AU2001265343B2 (en) 2006-08-03
EP1299327A2 (fr) 2003-04-09
JP2003534790A (ja) 2003-11-25
WO2001092469A2 (fr) 2001-12-06
AU6534301A (en) 2001-12-11
EP1299327A4 (fr) 2005-03-02
WO2001092469A3 (fr) 2002-05-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued