CA2408835A1 - Compositions et methodes pour la cartographie d'epitopes - Google Patents

Compositions et methodes pour la cartographie d'epitopes Download PDF

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Publication number
CA2408835A1
CA2408835A1 CA002408835A CA2408835A CA2408835A1 CA 2408835 A1 CA2408835 A1 CA 2408835A1 CA 002408835 A CA002408835 A CA 002408835A CA 2408835 A CA2408835 A CA 2408835A CA 2408835 A1 CA2408835 A1 CA 2408835A1
Authority
CA
Canada
Prior art keywords
reagent
ligands
antibody
sample
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002408835A
Other languages
English (en)
Inventor
David P. Dumas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2408835A1 publication Critical patent/CA2408835A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

L'invention concerne une composition comprenant une population diversifiée de ligands réactifs fixés à un support solide ainsi qu'une population diversifiée d'anticorps réactifs spécifiquement liés aux ligands réactifs. Ces ligands peuvent être des peptides, des oligosaccharides, des oligonucléotides ou des molécules organiques. L'invention concerne également des méthodes visant à déterminer un épitope dans un échantillon mis en contact avec une composition renfermant une population diversifiée de ligands fixés à un support solide ainsi qu'une population diversifiée d'anticorps spécifiquement liés à chacun de ces ligands avec un échantillon, puis à détecter les anticorps liés à la population diversifiée de ligands. L'invention concerne en outre des méthodes destinées à diagnostiquer une maladie, à identifier un agent thérapeutique potentiel et à cartographier les épitopes accessibles d'un polypeptide au moyen des compositions de l'invention.
CA002408835A 2000-05-12 2001-05-10 Compositions et methodes pour la cartographie d'epitopes Abandoned CA2408835A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56971300A 2000-05-12 2000-05-12
US09/569,713 2000-05-12
PCT/US2001/015450 WO2001088538A2 (fr) 2000-05-12 2001-05-10 Compositions et methodes pour la cartographie d'epitopes

Publications (1)

Publication Number Publication Date
CA2408835A1 true CA2408835A1 (fr) 2001-11-22

Family

ID=24276552

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002408835A Abandoned CA2408835A1 (fr) 2000-05-12 2001-05-10 Compositions et methodes pour la cartographie d'epitopes

Country Status (4)

Country Link
EP (1) EP1314032A2 (fr)
AU (1) AU2001261533A1 (fr)
CA (1) CA2408835A1 (fr)
WO (1) WO2001088538A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310261A1 (de) * 2003-03-05 2004-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Identifizierung von Antigen-Epitopen
KR20120122869A (ko) 2009-06-02 2012-11-07 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법
TW201124726A (en) 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
GB201704823D0 (en) * 2017-03-27 2017-05-10 Univ Leicester Methods and kits for determining binding sites
CN114853848B (zh) * 2022-05-24 2023-10-24 陕西慧康生物科技有限责任公司 多肽类化合物及其在制备治疗肝纤维化疾病药物中的应用
WO2024059655A1 (fr) * 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Caractérisation de l'accessibilité de structures macromoléculaires

Also Published As

Publication number Publication date
EP1314032A2 (fr) 2003-05-28
AU2001261533A1 (en) 2001-11-26
WO2001088538A3 (fr) 2003-03-27
WO2001088538A8 (fr) 2002-03-28
WO2001088538A2 (fr) 2001-11-22

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Legal Events

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