CA2408667A1 - Phosphate transport inhibitors - Google Patents
Phosphate transport inhibitors Download PDFInfo
- Publication number
- CA2408667A1 CA2408667A1 CA002408667A CA2408667A CA2408667A1 CA 2408667 A1 CA2408667 A1 CA 2408667A1 CA 002408667 A CA002408667 A CA 002408667A CA 2408667 A CA2408667 A CA 2408667A CA 2408667 A1 CA2408667 A1 CA 2408667A1
- Authority
- CA
- Canada
- Prior art keywords
- benzamide
- bromophenyl
- bromo
- chlorophenyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims description 24
- 229910019142 PO4 Inorganic materials 0.000 title claims description 22
- 239000010452 phosphate Substances 0.000 title claims description 22
- 239000003112 inhibitor Substances 0.000 title description 6
- 208000020832 chronic kidney disease Diseases 0.000 claims abstract description 32
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims abstract description 28
- 208000020084 Bone disease Diseases 0.000 claims abstract description 10
- -1 arylcarbamyl Chemical group 0.000 claims description 43
- 150000001875 compounds Chemical class 0.000 claims description 34
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 22
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 18
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 16
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 16
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 16
- 210000003734 kidney Anatomy 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 9
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims description 8
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 8
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims description 8
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 8
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 125000005605 benzo group Chemical group 0.000 claims description 8
- 125000001188 haloalkyl group Chemical group 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 8
- 229930192474 thiophene Natural products 0.000 claims description 8
- NRKRPXPIMUPXSO-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-(3-chloropropylsulfonylamino)benzamide Chemical compound ClCCCS(=O)(=O)NC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 NRKRPXPIMUPXSO-UHFFFAOYSA-N 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- HCAWIDZCTIWCMU-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-[(2-fluorophenyl)sulfonylamino]benzamide Chemical compound FC1=CC=CC=C1S(=O)(=O)NC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 HCAWIDZCTIWCMU-UHFFFAOYSA-N 0.000 claims description 4
- DCHWSWIUQLKUPM-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-[(3-chloro-2-fluorophenyl)sulfonylamino]benzamide Chemical compound FC1=C(Cl)C=CC=C1S(=O)(=O)NC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 DCHWSWIUQLKUPM-UHFFFAOYSA-N 0.000 claims description 4
- HUNXHIHROQMRLU-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-[(4-methoxyphenyl)sulfonylamino]benzamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 HUNXHIHROQMRLU-UHFFFAOYSA-N 0.000 claims description 4
- WSOZAXMUCIEOOV-UHFFFAOYSA-N 5-bromo-n-(4-bromophenyl)-2-[(5-chlorothiophen-2-yl)sulfonylamino]benzamide Chemical compound S1C(Cl)=CC=C1S(=O)(=O)NC1=CC=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 WSOZAXMUCIEOOV-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000004442 acylamino group Chemical group 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 4
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 4
- 125000004414 alkyl thio group Chemical group 0.000 claims description 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 4
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims description 4
- 125000005239 aroylamino group Chemical group 0.000 claims description 4
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims description 4
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims description 4
- 125000001769 aryl amino group Chemical group 0.000 claims description 4
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims description 4
- 125000005421 aryl sulfonamido group Chemical group 0.000 claims description 4
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 4
- 125000005110 aryl thio group Chemical group 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims description 4
- CJRCDELEMCPVQN-UHFFFAOYSA-N 2-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-n-(4-chlorophenyl)benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)C1=CC=CC=C1NS(=O)(=O)C1=CC=CC2=NSN=C12 CJRCDELEMCPVQN-UHFFFAOYSA-N 0.000 claims description 3
- IRADZDAOMPBHHH-UHFFFAOYSA-N 2-(benzenesulfonamido)-n-(4-bromophenyl)benzamide Chemical compound C1=CC(Br)=CC=C1NC(=O)C1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 IRADZDAOMPBHHH-UHFFFAOYSA-N 0.000 claims description 3
- SXJOWOJDZHWDAP-UHFFFAOYSA-N 2-[(4-chlorophenyl)sulfonylamino]-5-methoxy-n-[3-(trifluoromethyl)phenyl]benzamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1NC(=O)C1=CC(OC)=CC=C1NS(=O)(=O)C1=CC=C(Cl)C=C1 SXJOWOJDZHWDAP-UHFFFAOYSA-N 0.000 claims description 3
- ABHVACOQLXSTRL-UHFFFAOYSA-N 5-bromo-n-(4-chlorophenyl)-2-[(3,4-dichlorophenyl)sulfonylamino]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)C1=CC(Br)=CC=C1NS(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 ABHVACOQLXSTRL-UHFFFAOYSA-N 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- QHBBRUNMXKPFCX-UHFFFAOYSA-N methyl 3-[[2-[(4-bromophenyl)carbamoyl]phenyl]sulfamoyl]thiophene-2-carboxylate Chemical compound S1C=CC(S(=O)(=O)NC=2C(=CC=CC=2)C(=O)NC=2C=CC(Br)=CC=2)=C1C(=O)OC QHBBRUNMXKPFCX-UHFFFAOYSA-N 0.000 claims description 3
- YJFZAVKWXZBSDL-UHFFFAOYSA-N n-(3,4-dichlorophenyl)-2-[(2-fluorophenyl)sulfonylamino]benzamide Chemical compound FC1=CC=CC=C1S(=O)(=O)NC1=CC=CC=C1C(=O)NC1=CC=C(Cl)C(Cl)=C1 YJFZAVKWXZBSDL-UHFFFAOYSA-N 0.000 claims description 3
- IEDKKYDVXYWGHP-UHFFFAOYSA-N n-(4-bromophenyl)-2-(thiophen-2-ylsulfonylamino)benzamide Chemical compound C1=CC(Br)=CC=C1NC(=O)C1=CC=CC=C1NS(=O)(=O)C1=CC=CS1 IEDKKYDVXYWGHP-UHFFFAOYSA-N 0.000 claims description 3
- XSTBCXIZGXSRFC-UHFFFAOYSA-N n-(4-bromophenyl)-5-chloro-2-[(3-chloro-2-fluorophenyl)sulfonylamino]benzamide Chemical compound FC1=C(Cl)C=CC=C1S(=O)(=O)NC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(Br)C=C1 XSTBCXIZGXSRFC-UHFFFAOYSA-N 0.000 claims description 3
- ASCOCYHAPWYEIP-UHFFFAOYSA-N n-(4-butoxyphenyl)-2-[(3,4-difluorophenyl)sulfonylamino]benzamide Chemical compound C1=CC(OCCCC)=CC=C1NC(=O)C1=CC=CC=C1NS(=O)(=O)C1=CC=C(F)C(F)=C1 ASCOCYHAPWYEIP-UHFFFAOYSA-N 0.000 claims description 3
- XLJBFJLPDVBNJY-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[(2-fluorophenyl)sulfonylamino]benzamide Chemical compound FC1=CC=CC=C1S(=O)(=O)NC1=CC=CC=C1C(=O)NC1=CC=C(Cl)C=C1 XLJBFJLPDVBNJY-UHFFFAOYSA-N 0.000 claims description 3
- SHXPBUVPBXVCSF-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[(3,4-dichlorophenyl)sulfonylamino]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)C1=CC=CC=C1NS(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 SHXPBUVPBXVCSF-UHFFFAOYSA-N 0.000 claims description 3
- QWYVEPXXCBVMKY-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[(3,4-difluorophenyl)sulfonylamino]benzamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC1=CC=CC=C1C(=O)NC1=CC=C(Cl)C=C1 QWYVEPXXCBVMKY-UHFFFAOYSA-N 0.000 claims description 3
- GKBOHTHLKUBUOW-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonylamino]benzamide Chemical compound CC1=NOC(C)=C1S(=O)(=O)NC1=CC=CC=C1C(=O)NC1=CC=C(Cl)C=C1 GKBOHTHLKUBUOW-UHFFFAOYSA-N 0.000 claims description 3
- OFVWWWFGPJBFTO-UHFFFAOYSA-N n-(4-chlorophenyl)-2-[[3-(trifluoromethyl)phenyl]sulfonylamino]benzamide Chemical compound FC(F)(F)C1=CC=CC(S(=O)(=O)NC=2C(=CC=CC=2)C(=O)NC=2C=CC(Cl)=CC=2)=C1 OFVWWWFGPJBFTO-UHFFFAOYSA-N 0.000 claims description 3
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- ZHNFLHYOFXQIOW-LPYZJUEESA-N quinine sulfate dihydrate Chemical compound [H+].[H+].O.O.[O-]S([O-])(=O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-LPYZJUEESA-N 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000005504 styryl group Chemical group 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20399500P | 2000-05-12 | 2000-05-12 | |
| US60/203,995 | 2000-05-12 | ||
| PCT/US2001/015324 WO2001087294A1 (en) | 2000-05-12 | 2001-05-11 | Phosphate transport inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2408667A1 true CA2408667A1 (en) | 2001-11-22 |
Family
ID=22756167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002408667A Abandoned CA2408667A1 (en) | 2000-05-12 | 2001-05-11 | Phosphate transport inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2003533477A (cs) |
| KR (1) | KR20020093983A (cs) |
| CN (1) | CN1429108A (cs) |
| AU (1) | AU2001261471A1 (cs) |
| BR (1) | BR0110034A (cs) |
| CA (1) | CA2408667A1 (cs) |
| CZ (1) | CZ20023701A3 (cs) |
| HU (1) | HUP0302234A2 (cs) |
| IL (1) | IL152587A0 (cs) |
| MX (1) | MXPA02011160A (cs) |
| NO (1) | NO20025399D0 (cs) |
| PL (1) | PL359931A1 (cs) |
| WO (1) | WO2001087294A1 (cs) |
| ZA (1) | ZA200209106B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2378179A (en) * | 2001-08-03 | 2003-02-05 | Pantherix Ltd | Aromatic sulfonamides and their use in treating bacterial diseases |
| US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| MX2011007024A (es) | 2008-12-31 | 2011-09-27 | Aedelyx Inc | Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| CN103183623A (zh) * | 2013-03-12 | 2013-07-03 | 中国医学科学院医药生物技术研究所 | 一组苯磺酰胺基苯甲酰胺类衍生物及制备和应用 |
| KR20250026881A (ko) | 2013-04-12 | 2025-02-25 | 알데릭스, 인코포레이티드 | Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법 |
| US9765050B2 (en) | 2014-12-30 | 2017-09-19 | Novira Therapeutics, Inc. | Pyridyl reverse sulfonamides for HBV treatment |
| CN105395532B (zh) * | 2015-11-25 | 2017-11-14 | 中国医学科学院医药生物技术研究所 | 2‑苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用 |
| WO2018043400A1 (ja) * | 2016-08-30 | 2018-03-08 | 日本曹達株式会社 | スルホニルアミノベンズアミド化合物および有害生物防除剤 |
| MA47203A (fr) | 2017-01-09 | 2019-11-13 | Ardelyx Inc | Inhibiteurs d'antiport à médiation par nhe |
| MX395405B (es) | 2017-01-09 | 2025-03-25 | Ardelyx Inc | Compuestos útiles para tratar trastornos del tracto gastrointestinal. |
| US11390599B2 (en) | 2018-06-01 | 2022-07-19 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146513A0 (en) * | 1999-06-24 | 2002-07-25 | Smithkline Beecham Corp | Macrophage scavenger receptor antagonists |
| AR030911A1 (es) * | 1999-07-20 | 2003-09-03 | Smithkline Beecham Corp | Uso de n-aril-2-sulfonamidobenzamidas para la manufactura de un medicamento para el tratamiento de la insuficiencia renal cronica y composiciones farmaceuticas |
-
2001
- 2001-05-11 CA CA002408667A patent/CA2408667A1/en not_active Abandoned
- 2001-05-11 WO PCT/US2001/015324 patent/WO2001087294A1/en not_active Application Discontinuation
- 2001-05-11 BR BR0110034-3A patent/BR0110034A/pt not_active Application Discontinuation
- 2001-05-11 IL IL15258701A patent/IL152587A0/xx unknown
- 2001-05-11 MX MXPA02011160A patent/MXPA02011160A/es unknown
- 2001-05-11 CN CN01809376A patent/CN1429108A/zh active Pending
- 2001-05-11 CZ CZ20023701A patent/CZ20023701A3/cs unknown
- 2001-05-11 KR KR1020027015094A patent/KR20020093983A/ko not_active Withdrawn
- 2001-05-11 PL PL35993101A patent/PL359931A1/xx not_active Application Discontinuation
- 2001-05-11 HU HU0302234A patent/HUP0302234A2/hu unknown
- 2001-05-11 JP JP2001583762A patent/JP2003533477A/ja not_active Withdrawn
- 2001-05-11 AU AU2001261471A patent/AU2001261471A1/en not_active Abandoned
-
2002
- 2002-11-08 ZA ZA200209106A patent/ZA200209106B/xx unknown
- 2002-11-11 NO NO20025399A patent/NO20025399D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0110034A (pt) | 2003-05-27 |
| JP2003533477A (ja) | 2003-11-11 |
| CN1429108A (zh) | 2003-07-09 |
| WO2001087294A1 (en) | 2001-11-22 |
| NO20025399L (no) | 2002-11-11 |
| ZA200209106B (en) | 2003-10-23 |
| PL359931A1 (en) | 2004-09-06 |
| AU2001261471A1 (en) | 2001-11-26 |
| CZ20023701A3 (cs) | 2003-11-12 |
| IL152587A0 (en) | 2003-05-29 |
| NO20025399D0 (no) | 2002-11-11 |
| HUP0302234A2 (hu) | 2003-11-28 |
| KR20020093983A (ko) | 2002-12-16 |
| MXPA02011160A (es) | 2003-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |