CA2408410A1 - Procede et dispositif de purification multicanal haut debit - Google Patents

Procede et dispositif de purification multicanal haut debit Download PDF

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Publication number
CA2408410A1
CA2408410A1 CA002408410A CA2408410A CA2408410A1 CA 2408410 A1 CA2408410 A1 CA 2408410A1 CA 002408410 A CA002408410 A CA 002408410A CA 2408410 A CA2408410 A CA 2408410A CA 2408410 A1 CA2408410 A1 CA 2408410A1
Authority
CA
Canada
Prior art keywords
sample
flow
chamber
outlet
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002408410A
Other languages
English (en)
Inventor
Donald A Wendell
Romaine Maiefski
Jonathan D. Krakover
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ontogen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/569,374 external-priority patent/US6358413B1/en
Priority claimed from US09/569,378 external-priority patent/US6458273B1/en
Priority claimed from US09/569,382 external-priority patent/US6355164B1/en
Priority claimed from US09/569,377 external-priority patent/US6358414B1/en
Application filed by Individual filed Critical Individual
Publication of CA2408410A1 publication Critical patent/CA2408410A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D16/00—Control of fluid pressure
    • G05D16/20—Control of fluid pressure characterised by the use of electric means
    • G05D16/2006—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means
    • G05D16/2013—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means
    • G05D16/202—Control of fluid pressure characterised by the use of electric means with direct action of electric energy on controlling means using throttling means as controlling means actuated by an electric motor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1885—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/40—Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00759—Purification of compounds synthesised
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Automation & Control Theory (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Paper (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

La présente invention concerne un procédé et un dispositif de purification multicanal haut débit. L'invention concerne plus particulièrement un ensemble régulateur manostatique conçu notamment pour un système de purification multicanal haut débit. Cet ensemble régulateur manostatique assure la régulation la pression du fluide circulant dans le système de purification. L'appareil inclut un micro-échantillonneur utilisé dans un système de purification multicanal haut débit pour purifier une pluralité d'échantillons, quatre au moins de préférence, provenant d'une échantillothèque chimique. L'appareil comporte également un ensemble colonne de chromatographie en phase liquide à haut débit servant à séparer un gros échantillon d'un poids massique et d'un volume fluidique sélectionné. L'appareil comporte également un ensemble collecteur de fraction pourvu d'un châssis et d'une tête de distribution montée sur le châssis où elle est mobile autour de trois axes. Un poste de rinçage, solidaire du châssis, est positionné de façon à recevoir amovible le tube de distribution lorsque la tête de distribution est en position de rinçage. Un poste de manipulateur est installé contre un ensemble de distribution à chambre d'expansion de façon à maintenir les chambres d'expansion dans une position sélectionnée leur permettant d'être saisies par la tête de distribution lorsqu'elle est en position de saisie préalablement à une distribution de l'échantillon dans le récipient receveur.
CA002408410A 2000-05-11 2001-05-11 Procede et dispositif de purification multicanal haut debit Abandoned CA2408410A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US09/569,378 2000-05-11
US09/569,374 US6358413B1 (en) 1999-10-29 2000-05-11 Microsampling apparatus and method for multiple channel high throughout purification
US09/569,378 US6458273B1 (en) 1999-10-29 2000-05-11 Sample separation apparatus and method for multiple channel high throughput purification
US09/569,382 US6355164B1 (en) 1999-10-29 2000-05-11 Sample collection apparatus and method for multiple channel high throughput purification
US09/569,382 2000-05-11
US09/569,377 US6358414B1 (en) 1999-10-29 2000-05-11 Pressure regulation apparatus and method for multiple channel high throughput purification
US09/569,374 2000-05-11
US09/569,377 2000-05-11
PCT/US2001/015469 WO2001086283A2 (fr) 2000-05-11 2001-05-11 Procede et dispositif de purification multicanal haut debit

Publications (1)

Publication Number Publication Date
CA2408410A1 true CA2408410A1 (fr) 2001-11-15

Family

ID=27504881

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002408410A Abandoned CA2408410A1 (fr) 2000-05-11 2001-05-11 Procede et dispositif de purification multicanal haut debit

Country Status (5)

Country Link
EP (1) EP1281075A2 (fr)
JP (1) JP2004510126A (fr)
AU (1) AU2001261545A1 (fr)
CA (1) CA2408410A1 (fr)
WO (1) WO2001086283A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
WO2003068402A1 (fr) 2002-02-13 2003-08-21 Nanostream, Inc. Dispositifs a colonnes de separation microfluidique, et procedes de fabrication
US6936167B2 (en) 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
EP1775001A1 (fr) * 2005-10-13 2007-04-18 Xendo Holding B.V. Dispositif pour séparations chromatographiques
JP5833925B2 (ja) * 2008-09-29 2015-12-16 ウオーターズ・テクノロジーズ・コーポレイシヨン 並行スクリーニングの超臨界流体クロマトグラフィ
US8307843B2 (en) * 2009-01-21 2012-11-13 Tescom Corporation Temperature-controlled pressure regulators
US9535427B2 (en) * 2009-01-21 2017-01-03 Tescom Corporation Temperature-controlled pressure regulators
EP2825878A4 (fr) * 2012-03-08 2016-07-20 Waters Technologies Corp Régulation de contre-pression
US11435324B2 (en) * 2017-09-15 2022-09-06 Shimadzu Corporation Supercritical fluid apparatus
CN212207226U (zh) * 2020-06-10 2020-12-22 上海贝高医疗科技有限公司 一种与液相色谱仪配套使用的静态进样和流分收集装置
CN113466105B (zh) * 2021-07-01 2022-04-12 西南石油大学 一种致密气藏启动压力梯度的确定方法
CN113804529A (zh) * 2021-10-26 2021-12-17 济南中意维尔科技有限公司 一种烧结球团矿的机器人制样系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417882A3 (en) * 1989-09-14 1992-10-21 Intel Gasgards Private Limited Improvements in and relating to gas pressure regulators
US5411053A (en) * 1994-07-01 1995-05-02 Daniel A. Holt Fluid pressure regulator
JP3368117B2 (ja) * 1995-09-29 2003-01-20 幸彦 唐澤 固体粒子の破砕方法および装置
EP1125122A1 (fr) * 1998-10-30 2001-08-22 Ontogen Corporation Dispositif et technique de purification multicanal a debit eleve

Also Published As

Publication number Publication date
AU2001261545A1 (en) 2001-11-20
WO2001086283A2 (fr) 2001-11-15
WO2001086283A3 (fr) 2002-05-16
EP1281075A2 (fr) 2003-02-05
JP2004510126A (ja) 2004-04-02

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Legal Events

Date Code Title Description
FZDE Discontinued