CA2405419A1 - Apomorphine derivatives and methods for their use - Google Patents
Apomorphine derivatives and methods for their use Download PDFInfo
- Publication number
- CA2405419A1 CA2405419A1 CA002405419A CA2405419A CA2405419A1 CA 2405419 A1 CA2405419 A1 CA 2405419A1 CA 002405419 A CA002405419 A CA 002405419A CA 2405419 A CA2405419 A CA 2405419A CA 2405419 A1 CA2405419 A1 CA 2405419A1
- Authority
- CA
- Canada
- Prior art keywords
- apomorphine
- norapomorphine
- patient
- sulfate
- glucuronide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 title claims abstract description 32
- 229960004046 apomorphine Drugs 0.000 claims abstract description 78
- MHPQCGZBAVXCGA-GFCCVEGCSA-N (6ar)-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol Chemical group N1CCC2=CC=CC3=C2[C@H]1CC1=CC=C(O)C(O)=C13 MHPQCGZBAVXCGA-GFCCVEGCSA-N 0.000 claims abstract description 29
- -1 Apomorphine derivative compounds Chemical class 0.000 claims abstract description 29
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- FEZBIKUBAYAZIU-UHFFFAOYSA-N trimethobenzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)NCC=2C=CC(OCCN(C)C)=CC=2)=C1 FEZBIKUBAYAZIU-UHFFFAOYSA-N 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical class CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000006441 vascular event Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229940072018 zofran Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19565000P | 2000-04-07 | 2000-04-07 | |
| US60/195,650 | 2000-04-07 | ||
| PCT/US2001/040393 WO2001076602A1 (en) | 2000-04-07 | 2001-03-29 | Apomorphine derivatives and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2405419A1 true CA2405419A1 (en) | 2001-10-18 |
Family
ID=22722192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002405419A Abandoned CA2405419A1 (en) | 2000-04-07 | 2001-03-29 | Apomorphine derivatives and methods for their use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6506765B2 (OSRAM) |
| EP (1) | EP1284735A4 (OSRAM) |
| JP (1) | JP2003532640A (OSRAM) |
| KR (1) | KR20030036157A (OSRAM) |
| CN (1) | CN1471395A (OSRAM) |
| AU (1) | AU2001255818A1 (OSRAM) |
| BG (1) | BG107217A (OSRAM) |
| BR (1) | BR0109515A (OSRAM) |
| CA (1) | CA2405419A1 (OSRAM) |
| CZ (1) | CZ20023637A3 (OSRAM) |
| HU (1) | HUP0301773A3 (OSRAM) |
| IL (1) | IL151614A0 (OSRAM) |
| MX (1) | MXPA02009904A (OSRAM) |
| NO (1) | NO20024806D0 (OSRAM) |
| PL (1) | PL361672A1 (OSRAM) |
| SK (1) | SK15772002A3 (OSRAM) |
| WO (1) | WO2001076602A1 (OSRAM) |
| ZA (1) | ZA200207489B (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002934D0 (sv) * | 2000-08-17 | 2000-08-17 | Axon Biochemicals Bv | New aporphine esters and in their use in therapy |
| SE0102036D0 (sv) * | 2001-06-08 | 2001-06-08 | Axon Biochemicals Bv | Pharmaceutical formulation for the efficient administration of apomorphine, 6aR- (-) -N- Propyl- norapomorphine and their derivatives and pro-drugs thereof |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US6737042B2 (en) * | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| WO2003080074A1 (en) * | 2002-03-19 | 2003-10-02 | Michael Holick | Glycoside and orthoester glycoside derivatives of apomorphine, analogs, and uses thereof |
| WO2004069167A2 (en) * | 2003-01-31 | 2004-08-19 | Nastech Pharmaceutical Company Inc. | Method and compositions for treating male infertility |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| US20060178394A1 (en) * | 2003-04-14 | 2006-08-10 | Staniforth John N | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| JP5584415B2 (ja) | 2005-10-12 | 2014-09-03 | ユニメッド・ファーマシューティカルズ・エルエルシー | 改良したテストステロンゲル製剤及び使用の方法 |
| GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
| GB0721394D0 (en) * | 2007-10-31 | 2007-12-12 | Vectura Group Plc | Compositions for trating parkinson's disease |
| KR102712887B1 (ko) | 2017-11-24 | 2024-10-02 | 하. 룬드벡 아크티에셀스카브 | 파킨슨병의 치료에 사용하기 위한 새로운 카테콜아민 전구약물 |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| JP7562562B2 (ja) | 2019-05-21 | 2024-10-07 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| US12398106B2 (en) | 2019-05-21 | 2025-08-26 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson's disease |
| EP3972970A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
| CN113677675B (zh) | 2019-05-21 | 2024-07-26 | H.隆德贝克有限公司 | 用于治疗帕金森病的新儿茶酚胺前药 |
| US20240335379A1 (en) * | 2021-08-05 | 2024-10-10 | Zydus Lifesciences Limited | Stable pharmaceutical compositions of apomorphine |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4127118B1 (en) | 1977-03-16 | 1995-12-19 | Alvaro Latorre | Method of effecting and enhancing an erection |
| US4521421A (en) * | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
| US4801587A (en) | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
| US5256652A (en) | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
| PT689438E (pt) | 1993-03-26 | 2003-10-31 | Franciscus Wilhelmus He Merkus | Composicoes farmaceuticas para administracao intranasal de apomorfina |
| ATE189121T1 (de) | 1994-04-22 | 2000-02-15 | Pentech Pharmaceuticals Inc | Sublinguale dosierungsformen enthaltend apomorphin zur verwendung bei der behandlung von erektiler dysfunktion |
| US5562917A (en) | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| US5888534A (en) | 1995-06-13 | 1999-03-30 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| DK0914097T3 (da) | 1996-03-12 | 2002-04-29 | Alza Corp | Sammensætning og doseringsform omfattende opioid antagonist |
| GB9700878D0 (en) | 1997-01-17 | 1997-03-05 | Scherer Ltd R P | Dosage forms and method for ameliorating male erectile dysfunction |
| US5925629A (en) * | 1997-10-28 | 1999-07-20 | Vivus, Incorporated | Transurethral administration of androgenic agents for the treatment of erectile dysfunction |
| DK1035833T3 (da) | 1997-12-02 | 2006-01-09 | Archimedes Dev Ltd | Sammensætning til nasal indgivelse |
| US5945117A (en) | 1998-01-30 | 1999-08-31 | Pentech Pharmaceuticals, Inc. | Treatment of female sexual dysfunction |
| JP2002518435A (ja) * | 1998-06-22 | 2002-06-25 | クイーンズ ユニバーシティ アット キングストン | 女性の性機能不全の治療または改善のための方法および組成物 |
| IT1299566B1 (it) * | 1998-07-17 | 2000-03-16 | Ifi Istituto Farmacoterapico I | Cerotto transdermico e composizioni farmaceutiche comprendenti r (-)- norapropilapomorfina cloridrato e/o s (+) - norapropilapomorfina |
| US5994363A (en) | 1998-08-24 | 1999-11-30 | Pentech Pharmaceuticals, Inc. | Amelioration of apomorphine adverse effects |
| EP1175206A1 (en) * | 1999-05-13 | 2002-01-30 | Unihart Corporation | Pharmaceutical compositions comprising apocodeine and/or its derivatives |
-
2001
- 2001-03-29 SK SK1577-2002A patent/SK15772002A3/sk not_active Application Discontinuation
- 2001-03-29 EP EP01929027A patent/EP1284735A4/en not_active Withdrawn
- 2001-03-29 KR KR1020027013436A patent/KR20030036157A/ko not_active Withdrawn
- 2001-03-29 CA CA002405419A patent/CA2405419A1/en not_active Abandoned
- 2001-03-29 US US09/821,236 patent/US6506765B2/en not_active Expired - Fee Related
- 2001-03-29 IL IL15161401A patent/IL151614A0/xx unknown
- 2001-03-29 JP JP2001574119A patent/JP2003532640A/ja not_active Withdrawn
- 2001-03-29 HU HU0301773A patent/HUP0301773A3/hu unknown
- 2001-03-29 CZ CZ20023637A patent/CZ20023637A3/cs unknown
- 2001-03-29 BR BR0109515-3A patent/BR0109515A/pt not_active IP Right Cessation
- 2001-03-29 WO PCT/US2001/040393 patent/WO2001076602A1/en not_active Ceased
- 2001-03-29 MX MXPA02009904A patent/MXPA02009904A/es unknown
- 2001-03-29 AU AU2001255818A patent/AU2001255818A1/en not_active Abandoned
- 2001-03-29 PL PL01361672A patent/PL361672A1/xx not_active Application Discontinuation
- 2001-03-29 CN CNA01815168XA patent/CN1471395A/zh active Pending
-
2002
- 2002-09-18 ZA ZA200207489A patent/ZA200207489B/xx unknown
- 2002-10-04 NO NO20024806A patent/NO20024806D0/no not_active Application Discontinuation
- 2002-10-24 BG BG107217A patent/BG107217A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001255818A1 (en) | 2001-10-23 |
| KR20030036157A (ko) | 2003-05-09 |
| MXPA02009904A (es) | 2004-09-06 |
| EP1284735A1 (en) | 2003-02-26 |
| CN1471395A (zh) | 2004-01-28 |
| HUP0301773A2 (hu) | 2003-09-29 |
| IL151614A0 (en) | 2003-04-10 |
| WO2001076602A1 (en) | 2001-10-18 |
| BG107217A (bg) | 2003-05-30 |
| CZ20023637A3 (cs) | 2003-02-12 |
| PL361672A1 (en) | 2004-10-04 |
| SK15772002A3 (sk) | 2003-09-11 |
| JP2003532640A (ja) | 2003-11-05 |
| EP1284735A4 (en) | 2006-01-11 |
| US6506765B2 (en) | 2003-01-14 |
| BR0109515A (pt) | 2004-08-10 |
| NO20024806D0 (no) | 2002-10-04 |
| US20020002176A1 (en) | 2002-01-03 |
| ZA200207489B (en) | 2003-12-18 |
| HUP0301773A3 (en) | 2006-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |