CA2404278C - Naphthalimide compositions and uses thereof - Google Patents
Naphthalimide compositions and uses thereof Download PDFInfo
- Publication number
- CA2404278C CA2404278C CA2404278A CA2404278A CA2404278C CA 2404278 C CA2404278 C CA 2404278C CA 2404278 A CA2404278 A CA 2404278A CA 2404278 A CA2404278 A CA 2404278A CA 2404278 C CA2404278 C CA 2404278C
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- CA
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- Prior art keywords
- amonafide
- antiproliferative agent
- agent
- antiproliferative
- modulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 73
- UPALIKSFLSVKIS-UHFFFAOYSA-N 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione Chemical compound NC1=CC(C(N(CCN(C)C)C2=O)=O)=C3C2=CC=CC3=C1 UPALIKSFLSVKIS-UHFFFAOYSA-N 0.000 claims abstract description 63
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- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19710300P | 2000-04-12 | 2000-04-12 | |
| US60/197,103 | 2000-04-12 | ||
| PCT/US2001/012169 WO2001078705A2 (en) | 2000-04-12 | 2001-04-12 | Compositions containing a naphthalmide and an antiproliferative agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2404278A1 CA2404278A1 (en) | 2001-10-25 |
| CA2404278C true CA2404278C (en) | 2010-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2404278A Expired - Fee Related CA2404278C (en) | 2000-04-12 | 2001-04-12 | Naphthalimide compositions and uses thereof |
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| Country | Link |
|---|---|
| US (2) | US6630173B2 (enExample) |
| EP (1) | EP1274458B1 (enExample) |
| JP (1) | JP2003530431A (enExample) |
| AT (1) | ATE305312T1 (enExample) |
| AU (1) | AU5348301A (enExample) |
| CA (1) | CA2404278C (enExample) |
| DE (1) | DE60113666T2 (enExample) |
| ES (1) | ES2248312T3 (enExample) |
| HK (1) | HK1052874B (enExample) |
| WO (1) | WO2001078705A2 (enExample) |
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| PT1263440E (pt) * | 2000-03-15 | 2006-11-30 | Chemgenex Pharmaceuticals Inc | Composições de combinação do alcalóide cefalotaxina e sua utilização |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
| US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US7135481B2 (en) * | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| US6693198B2 (en) | 2002-04-22 | 2004-02-17 | Xanthus Life Sciences, Inc. | Amonafide salts |
| US20050239816A1 (en) * | 2002-04-22 | 2005-10-27 | Xanthus Life Sciences, Inc. | Amonafide salts |
| US7105576B2 (en) * | 2002-04-24 | 2006-09-12 | Research Development Foundation | Synergistic effects of nuclear transcription factor NF-κB inhibitors and anti-neoplastic agents |
| US20040082788A1 (en) * | 2002-07-08 | 2004-04-29 | Chemgenex Therapeutics, Inc. | Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof |
| US20040082565A1 (en) * | 2002-07-17 | 2004-04-29 | Chemgenex Therapeutics, Inc. | Formulations and methods of administration of cephalotaxines including homoharringtonine |
| US7642252B2 (en) * | 2002-07-22 | 2010-01-05 | Chemgenex Pharmaceuticals, Inc. | Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof |
| AU2005209845A1 (en) * | 2004-01-30 | 2005-08-18 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide dosing by N-acetyl transferase genotyping |
| EP1765341A4 (en) * | 2004-06-04 | 2010-04-14 | Chemgenex Pharmaceuticals Inc | PROCESS FOR TREATING PROLIFERATIVE CELL DISEASE USING NAPHTHALIMIDE AND PARP-1 INHIBITORS |
| EP1848391A2 (en) * | 2005-02-10 | 2007-10-31 | ChemGenex Pharmaceuticals, Inc. | Medical devices |
| CN103285015B (zh) * | 2007-04-13 | 2016-04-27 | 化学基因制药公司 | 三尖杉碱口服剂型 |
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| US5183821A (en) * | 1983-09-19 | 1993-02-02 | Laboratories Knoll, S.A. | Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors |
| US5420137A (en) | 1989-07-11 | 1995-05-30 | Knoll Ag | Amonafide salts |
| FR2673944B1 (fr) * | 1991-03-13 | 1995-03-10 | Sanofi Elf | Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| CA2294247C (en) * | 1997-07-01 | 2004-10-26 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| PT1263440E (pt) * | 2000-03-15 | 2006-11-30 | Chemgenex Pharmaceuticals Inc | Composições de combinação do alcalóide cefalotaxina e sua utilização |
| EP1282445A2 (en) * | 2000-03-21 | 2003-02-12 | Atherogenics, Inc. | N-substituted dithiocarbamates for the treatment of biological disorders |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
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2001
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2003
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| HK1052874B (en) | 2006-05-04 |
| HK1052874A1 (en) | 2003-10-03 |
| EP1274458A2 (en) | 2003-01-15 |
| EP1274458B1 (en) | 2005-09-28 |
| US20040047918A1 (en) | 2004-03-11 |
| CA2404278A1 (en) | 2001-10-25 |
| JP2003530431A (ja) | 2003-10-14 |
| ES2248312T3 (es) | 2006-03-16 |
| DE60113666T2 (de) | 2006-06-14 |
| US6630173B2 (en) | 2003-10-07 |
| DE60113666D1 (de) | 2005-11-03 |
| WO2001078705A3 (en) | 2002-06-20 |
| US20020025916A1 (en) | 2002-02-28 |
| WO2001078705A2 (en) | 2001-10-25 |
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