CA2404278C - Naphthalimide compositions and uses thereof - Google Patents
Naphthalimide compositions and uses thereof Download PDFInfo
- Publication number
- CA2404278C CA2404278C CA2404278A CA2404278A CA2404278C CA 2404278 C CA2404278 C CA 2404278C CA 2404278 A CA2404278 A CA 2404278A CA 2404278 A CA2404278 A CA 2404278A CA 2404278 C CA2404278 C CA 2404278C
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- CA
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- Prior art keywords
- amonafide
- antiproliferative agent
- agent
- antiproliferative
- modulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 73
- UPALIKSFLSVKIS-UHFFFAOYSA-N 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione Chemical compound NC1=CC(C(N(CCN(C)C)C2=O)=O)=C3C2=CC=CC3=C1 UPALIKSFLSVKIS-UHFFFAOYSA-N 0.000 claims abstract description 63
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19710300P | 2000-04-12 | 2000-04-12 | |
| US60/197,103 | 2000-04-12 | ||
| PCT/US2001/012169 WO2001078705A2 (en) | 2000-04-12 | 2001-04-12 | Compositions containing a naphthalmide and an antiproliferative agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2404278A1 CA2404278A1 (en) | 2001-10-25 |
| CA2404278C true CA2404278C (en) | 2010-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2404278A Expired - Fee Related CA2404278C (en) | 2000-04-12 | 2001-04-12 | Naphthalimide compositions and uses thereof |
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| Country | Link |
|---|---|
| US (2) | US6630173B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1274458B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003530431A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE305312T1 (cg-RX-API-DMAC7.html) |
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| DE (1) | DE60113666T2 (cg-RX-API-DMAC7.html) |
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| HK (1) | HK1052874B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001078705A2 (cg-RX-API-DMAC7.html) |
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| ES2267741T3 (es) * | 2000-03-15 | 2007-03-16 | Chemgenex Pharmaceuticals, Inc. | Composiciones combinadas de alcaloides de cefalotaxina y de los mismos. |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
| US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US7135481B2 (en) * | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| US20050239816A1 (en) * | 2002-04-22 | 2005-10-27 | Xanthus Life Sciences, Inc. | Amonafide salts |
| US6693198B2 (en) * | 2002-04-22 | 2004-02-17 | Xanthus Life Sciences, Inc. | Amonafide salts |
| JP2005529123A (ja) * | 2002-04-24 | 2005-09-29 | リサーチ ディベロップメント ファンデーション | 核転写調節因子ＮＦ−κＢ抑制剤と抗腫瘍薬の相乗効果 |
| EP1539150A4 (en) * | 2002-07-08 | 2006-10-11 | Chemgenex Pharmaceuticals Inc | SYNTHESIS OF NAPHTHALIMIDES, INCLUDING AMONAFIDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME |
| CA2492456A1 (en) * | 2002-07-17 | 2004-01-29 | Dennis M. Brown | Formulations and methods of administration of cephalotaxines, including homoharringtonine |
| WO2004009030A2 (en) * | 2002-07-22 | 2004-01-29 | Chemgenex Pharmaceuticals Limited | Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof |
| JP2007525214A (ja) * | 2004-01-30 | 2007-09-06 | ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド | Ｎ−アセチルトランスフェラーゼ遺伝子型解析によって投与するナフタルイミド |
| CA2569279A1 (en) * | 2004-06-04 | 2005-12-15 | Chemgenex Pharmaceuticals, Inc. | Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors |
| CA2597323A1 (en) * | 2005-02-10 | 2006-08-17 | Chemgenex Pharmaceuticals, Inc. | Medical devices |
| CA2684219C (en) * | 2007-04-13 | 2017-05-23 | Chemgenex Pharmaceuticals, Inc. | Oral cephalotaxine dosage forms |
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| US5183821A (en) * | 1983-09-19 | 1993-02-02 | Laboratories Knoll, S.A. | Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors |
| US5420137A (en) | 1989-07-11 | 1995-05-30 | Knoll Ag | Amonafide salts |
| FR2673944B1 (fr) * | 1991-03-13 | 1995-03-10 | Sanofi Elf | Derives de l'1,8-naphtalimide, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| JP2002511878A (ja) * | 1997-07-01 | 2002-04-16 | アセロジエニクス・インコーポレイテツド | 抗酸化剤による過増殖状態の治療の増強 |
| ES2267741T3 (es) * | 2000-03-15 | 2007-03-16 | Chemgenex Pharmaceuticals, Inc. | Composiciones combinadas de alcaloides de cefalotaxina y de los mismos. |
| JP2003531138A (ja) * | 2000-03-21 | 2003-10-21 | アセロジエニクス・インコーポレイテツド | 生物学的疾患の治療のためのｎ−置換ジチオカルバメート |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
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- 2001-04-12 HK HK03105124.5A patent/HK1052874B/en not_active IP Right Cessation
- 2001-04-12 AU AU5348301A patent/AU5348301A/xx not_active Withdrawn
- 2001-04-12 US US09/834,177 patent/US6630173B2/en not_active Expired - Fee Related
- 2001-04-12 AT AT01926985T patent/ATE305312T1/de not_active IP Right Cessation
-
2003
- 2003-07-31 US US10/631,106 patent/US20040047918A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001078705A3 (en) | 2002-06-20 |
| HK1052874B (en) | 2006-05-04 |
| DE60113666T2 (de) | 2006-06-14 |
| CA2404278A1 (en) | 2001-10-25 |
| ATE305312T1 (de) | 2005-10-15 |
| ES2248312T3 (es) | 2006-03-16 |
| EP1274458A2 (en) | 2003-01-15 |
| DE60113666D1 (de) | 2005-11-03 |
| WO2001078705A2 (en) | 2001-10-25 |
| EP1274458B1 (en) | 2005-09-28 |
| HK1052874A1 (en) | 2003-10-03 |
| US20040047918A1 (en) | 2004-03-11 |
| US20020025916A1 (en) | 2002-02-28 |
| JP2003530431A (ja) | 2003-10-14 |
| US6630173B2 (en) | 2003-10-07 |
| AU5348301A (en) | 2001-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130412 |