CA2396674A1 - Compositions and methods involving an essential staphylococcus aureus gene and its encoded protein - Google Patents
Compositions and methods involving an essential staphylococcus aureus gene and its encoded protein Download PDFInfo
- Publication number
- CA2396674A1 CA2396674A1 CA002396674A CA2396674A CA2396674A1 CA 2396674 A1 CA2396674 A1 CA 2396674A1 CA 002396674 A CA002396674 A CA 002396674A CA 2396674 A CA2396674 A CA 2396674A CA 2396674 A1 CA2396674 A1 CA 2396674A1
- Authority
- CA
- Canada
- Prior art keywords
- aureus
- relates
- dnai
- protein
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 241000191967 Staphylococcus aureus Species 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 230000003993 interaction Effects 0.000 abstract 2
- 241001435321 Staphylococcus virus 77 Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000007878 drug screening assay Methods 0.000 abstract 1
- 108010072285 growth inhibitory proteins Proteins 0.000 abstract 1
- 108700010839 phage proteins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
This invention relates to newly identified polynucleotides and polypeptides, their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants. Also, the invention relates to a specific interaction between the S. aureus DnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage protein interacts with amino acids 150 -313 of S. aureus DnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. In addition, the invention relates to polynu-cleotides and polypeptides of a protein complex containing S. aureus DnaI and DnaC related proteins, as well as their variants.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/470,512 | 1999-12-22 | ||
| US09/470,512 US6376652B1 (en) | 1998-12-03 | 1999-12-22 | Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein |
| US09/689,952 US7101969B1 (en) | 1998-12-03 | 2000-10-12 | Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein |
| US09/689,952 | 2000-10-12 | ||
| PCT/US2000/035180 WO2001046383A2 (en) | 1999-12-22 | 2000-12-21 | Compositions and methods involving an essential staphylococcus aureus gene and its encoded protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2396674A1 true CA2396674A1 (en) | 2001-06-28 |
| CA2396674C CA2396674C (en) | 2006-07-04 |
Family
ID=27043114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002396674A Expired - Fee Related CA2396674C (en) | 1999-12-22 | 2000-12-21 | Compositions and methods involving an essential staphylococcus aureus gene and its encoded protein |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1242611A4 (en) |
| JP (1) | JP2003517833A (en) |
| AU (1) | AU778782B2 (en) |
| CA (1) | CA2396674C (en) |
| WO (1) | WO2001046383A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004522945A (en) * | 2000-12-01 | 2004-07-29 | ファゲテック，インコーポレイティド | Compositions and methods related to the Staphylococcus aureus essential gene and its encoded protein STAAU_R2 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU774841B2 (en) * | 1998-12-03 | 2004-07-08 | Targanta Therapeutics Inc. | Development of novel anti-microbial agents based on bacteriophage genomics |
-
2000
- 2000-12-21 WO PCT/US2000/035180 patent/WO2001046383A2/en active Search and Examination
- 2000-12-21 JP JP2001546881A patent/JP2003517833A/en active Pending
- 2000-12-21 CA CA002396674A patent/CA2396674C/en not_active Expired - Fee Related
- 2000-12-21 AU AU32662/01A patent/AU778782B2/en not_active Ceased
- 2000-12-21 EP EP00991434A patent/EP1242611A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001046383A2 (en) | 2001-06-28 |
| AU3266201A (en) | 2001-07-03 |
| EP1242611A4 (en) | 2004-08-11 |
| JP2003517833A (en) | 2003-06-03 |
| WO2001046383A3 (en) | 2002-01-03 |
| AU778782B2 (en) | 2004-12-23 |
| WO2001046383A9 (en) | 2002-07-11 |
| EP1242611A2 (en) | 2002-09-25 |
| CA2396674C (en) | 2006-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |