CA2394803A1 - Nouvelles proteines kinases humaines et enzymes analogues - Google Patents

Nouvelles proteines kinases humaines et enzymes analogues Download PDF

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Publication number
CA2394803A1
CA2394803A1 CA002394803A CA2394803A CA2394803A1 CA 2394803 A1 CA2394803 A1 CA 2394803A1 CA 002394803 A CA002394803 A CA 002394803A CA 2394803 A CA2394803 A CA 2394803A CA 2394803 A1 CA2394803 A1 CA 2394803A1
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Canada
Prior art keywords
seq
kinase
polypeptide
group
disease
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Abandoned
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CA002394803A
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English (en)
Inventor
Gregory D. Plowman
David Whyte
Gerard Manning
Sucha Sudarsanam
Ricardo Martinez
Peter Flanagan
Douglas Clary
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Sugen LLC
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Individual
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Publication of CA2394803A1 publication Critical patent/CA2394803A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)

Abstract

L'invention porte sur des polypeptides kinases, des séquences nucléotidiques codant pour elles et sur différents produits et procédés utiles pour le diagnostic et le traitement de différentes maladies et états liés aux kinases. En recourant à la bioinformatique, on a pu identifier des PTK et STK de mammifères et en prédire la structure protéique.
CA002394803A 1999-11-24 2000-11-22 Nouvelles proteines kinases humaines et enzymes analogues Abandoned CA2394803A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16748299P 1999-11-24 1999-11-24
US60/167,482 1999-11-24
PCT/US2000/032085 WO2001038503A2 (fr) 1999-11-24 2000-11-22 Nouvelles proteines kinases humaines et enzymes analogues

Publications (1)

Publication Number Publication Date
CA2394803A1 true CA2394803A1 (fr) 2001-05-31

Family

ID=22607536

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002394803A Abandoned CA2394803A1 (fr) 1999-11-24 2000-11-22 Nouvelles proteines kinases humaines et enzymes analogues

Country Status (5)

Country Link
EP (1) EP1240194A2 (fr)
JP (1) JP2003514583A (fr)
AU (1) AU1926001A (fr)
CA (1) CA2394803A1 (fr)
WO (1) WO2001038503A2 (fr)

Families Citing this family (57)

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US6787345B1 (en) 2000-11-15 2004-09-07 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
US6514719B1 (en) 1999-05-28 2003-02-04 Immunex Corporation Methods for identifying compounds that alter kinase activity
EP1484408A1 (fr) * 1999-09-28 2004-12-08 Lexicon Genetics Incorporated Proteines de kinase de l'homme et polynucleotides codant ces dernieres
US7241585B2 (en) 2000-02-11 2007-07-10 Millennium Pharmaceuticals, Inc. 14171 protein kinase, a novel human protein kinase and uses thereof
US6630335B1 (en) 2000-02-11 2003-10-07 Millennium Pharmaceuticals, Inc. 14171 protein kinase, a novel human protein kinase and uses thereof
US20020151005A1 (en) * 2000-06-15 2002-10-17 Meyers Rachel A. 53070, a novel human protein kinase family member and uses thereof
JP2003525636A (ja) 2000-03-08 2003-09-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヒトの細胞外シグナル制御キナーゼ
AU4352101A (en) 2000-03-10 2001-09-24 Lexicon Genetics Inc Novel human g-coupled protein receptor kinases and polynucleotides encoding the same
EP1272640A2 (fr) 2000-03-24 2003-01-08 Millennium Pharmaceuticals, Inc. 3714, 16742, 23546, et 13887 nouvelles molecules de proteine kinase et leurs utilisations
EP1272641A2 (fr) * 2000-04-10 2003-01-08 MERCK PATENT GmbH Nouvelle serine-threonine kinase (stk)
AU2001253489A1 (en) * 2000-04-13 2001-10-30 Millennium Pharmaceuticals, Inc. 14257,protein kinase molecules and uses therefor
WO2001081589A2 (fr) * 2000-04-25 2001-11-01 Millennium Pharmaceuticals, Inc. Nouvelles molecules de proteine kinase 14911 et leurs utilisations
WO2001081558A2 (fr) * 2000-04-25 2001-11-01 Millennium Pharmaceuticals, Inc. Nouvelles molecules 13295 de proteine kinase et leurs utilisations
JP2003531617A (ja) * 2000-05-05 2003-10-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 新規セリン−トレオニン・キナーゼ
US6534299B2 (en) * 2000-05-17 2003-03-18 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6482935B1 (en) 2000-05-24 2002-11-19 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6331423B1 (en) 2000-06-01 2001-12-18 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US7094587B2 (en) 2000-06-27 2006-08-22 Millennium Pharmaceuticals, Inc. 16002 Molecules and uses therefor
AU2001287557A1 (en) * 2000-07-05 2002-01-14 Merck Patent Gmbh Human serine-threonine kinase
US20020061573A1 (en) * 2000-07-28 2002-05-23 Rachel Meyers 18431 and 32374, novel human protein kinase family members and uses therefor
US7091022B2 (en) * 2000-08-11 2006-08-15 Merck Patent Gmbh Mitogen activated kinase
US6759221B1 (en) 2000-08-18 2004-07-06 Millennium Pharmaceuticals, Inc. 14189, a novel human kinase and uses thereof
AU2001285326A1 (en) * 2000-08-31 2002-03-13 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
AU2001288612A1 (en) * 2000-08-31 2002-03-13 Incyte Genomics, Inc. Human kinases
WO2002024889A2 (fr) * 2000-09-12 2002-03-28 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Contraction cardiaque optimisee par la phosphorylation differentielle de la myosine
US6984502B2 (en) 2000-10-19 2006-01-10 Millennium Pharmaceuticals, Inc. Methods and compositions of human 69087 nucleic acids and uses thereof
AU2002227352A1 (en) * 2000-10-20 2002-04-29 Incyte Genomics, Inc. Human kinases
PT1328621E (pt) * 2000-10-23 2007-03-30 Bayer Healthcare Ag 13245, uma nova proteína cinase humana de tipo distrofia miotónica e suas utilizações
JP2004517617A (ja) * 2000-12-07 2004-06-17 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼおよびそれをコードするポリヌクレオチド
WO2002055713A2 (fr) * 2000-12-08 2002-07-18 Millennium Pharm Inc 58848, un membre de la famille des proteine kinases humaines et utilisations de celui-ci
AU2002246858A1 (en) * 2000-12-27 2002-08-06 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
WO2002053749A2 (fr) * 2001-01-03 2002-07-11 Bayer Aktiengesellschaft Regulation de la proteine kinase serine/threonine humaine
US6638745B1 (en) * 2001-03-13 2003-10-28 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002081727A2 (fr) * 2001-04-03 2002-10-17 Pe Corporation (Ny) Proteines kinases humaines isolees, molecules d'acides nucleiques codant lesdites proteines kinases humaines, et leurs utilisations
EP1383879A4 (fr) * 2001-04-06 2005-05-11 Lexicon Genetics Inc Kinases humaines et polynucleotides codant pour celles-ci
WO2002083882A2 (fr) * 2001-04-12 2002-10-24 Bayer Aktiengesellschaft Regulation de proteine humaine de type serine/threonine proteine kinase
EP1396545A4 (fr) * 2001-06-04 2004-12-08 Taiho Pharmaceutical Co Ltd Facteur de regulation de cycle cellulaire
AU2002312241A1 (en) * 2001-06-05 2002-12-16 Exelixis, Inc. B3galts as modifiers of the p53 pathway and methods of use
AU2002350399A1 (en) * 2001-06-25 2003-01-08 Bayer Healthcare Ag Regulation of human nek-like serine/threonine protein kinase
WO2003004523A1 (fr) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation de la kinase humaine crik a interaction avec rho/rac
WO2003004629A2 (fr) * 2001-07-02 2003-01-16 Bayer Aktiengesellschaft Regulation d'une forme courte de kinase humaine a interaction rho/rac citron
WO2003007793A2 (fr) * 2001-07-17 2003-01-30 Yale University Compositions, methodes et trousses de traitement et diagnostic de l'hypertension
AU2002331162A1 (en) * 2001-08-20 2003-03-10 Bayer Healthcare Ag Human serine/threonine kinase
AU2002324058A1 (en) * 2001-08-21 2003-03-10 Bayer Healthcare Ag Regulation of human g protein-couple receptor kinase
AU2002352774A1 (en) * 2001-11-15 2003-05-26 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
EP1490484A2 (fr) * 2002-03-27 2004-12-29 Bayer HealthCare AG Autres kinases inductibles par bmp-2 et leurs utilisations
WO2003084992A1 (fr) * 2002-04-05 2003-10-16 Riken Nouvelles proteines et adn les codant
JP2003289876A (ja) * 2002-04-05 2003-10-14 Takeda Chem Ind Ltd がんの予防および／または治療剤
EP1576099A4 (fr) * 2002-04-12 2007-07-11 Bristol Myers Squibb Co Nouveaux polynucleotides codant le polypeptide kinase citron humain, bmsnkc 0020/0021
AU2003253880A1 (en) * 2002-07-15 2004-02-02 Sugen, Inc. Novel kinases
JP2006517387A (ja) * 2002-09-11 2006-07-27 ジェネンテック・インコーポレーテッド 腫瘍の診断と治療のための組成物と方法
AU2003262081A1 (en) * 2002-09-13 2004-04-30 Takeda Pharmaceutical Company Limited Preventives/remedies for neurodegenerative diseases
US20040248168A1 (en) 2003-03-25 2004-12-09 Wei Liu Novel brain-localized protein kinases homologous to homeodomain-interacting protein kinases
US20040265961A1 (en) * 2003-03-28 2004-12-30 Wei Liu Novel proteins homologous to kinase suppressor of Ras
WO2006040047A2 (fr) * 2004-10-15 2006-04-20 Bayer Healthcare Ag Diagnostics et therapeutiques pour des maladies associees a la kinase citron agissant sur rho/rac
EP3555116A4 (fr) * 2016-12-16 2020-07-22 The University Of Sydney Inhibiteurs de thrombine pour le traitement d'un accident vasculaire cérébral et de troubles de coagulation associés
EP3777857A1 (fr) 2019-08-12 2021-02-17 Københavns Universitet Ciblage de wnk1 dans les cancers du sang

Family Cites Families (6)

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EP0644939A4 (fr) * 1993-02-06 1997-08-20 Garvan Inst Med Res Proteine kinase c (iota).
US5532151A (en) * 1993-09-17 1996-07-02 Icos Corporation G protein-coupled receptor kinase GRK6
US5700675A (en) * 1995-12-13 1997-12-23 Regents Of The University Of California Protein kinase required for Ras signal transduction
US6001623A (en) * 1998-07-31 1999-12-14 Smithkline Beecham Corporation Human protein kinase H2LAU20
DE19842863A1 (de) * 1998-09-19 2000-04-27 Kramer Michael Regulatorisches Protein aus humanen Keratinozyten
CA2383244A1 (fr) * 1999-05-28 2000-12-07 Sugen, Inc. Proteines kinases

Also Published As

Publication number Publication date
JP2003514583A (ja) 2003-04-22
WO2001038503A2 (fr) 2001-05-31
AU1926001A (en) 2001-06-04
WO2001038503A3 (fr) 2002-01-31
EP1240194A2 (fr) 2002-09-18

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