CA2393251C - Eliciting hcv-specific antibodies - Google Patents
Eliciting hcv-specific antibodies Download PDFInfo
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- CA2393251C CA2393251C CA2393251A CA2393251A CA2393251C CA 2393251 C CA2393251 C CA 2393251C CA 2393251 A CA2393251 A CA 2393251A CA 2393251 A CA2393251 A CA 2393251A CA 2393251 C CA2393251 C CA 2393251C
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- Prior art keywords
- hcv
- polypeptide
- binding
- nob
- neutralization
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- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 239000008307 w/o/w-emulsion Substances 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
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- 238000002424 x-ray crystallography Methods 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16823499P | 1999-12-01 | 1999-12-01 | |
| US60/168,234 | 1999-12-01 | ||
| US18505500P | 2000-02-25 | 2000-02-25 | |
| US60/185,055 | 2000-02-25 | ||
| PCT/US2000/042541 WO2001047551A2 (en) | 1999-12-01 | 2000-12-01 | Eliciting antibodies specific for hepatitis c virus (hcv) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2393251A1 CA2393251A1 (en) | 2001-07-05 |
| CA2393251C true CA2393251C (en) | 2012-01-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2393251A Expired - Fee Related CA2393251C (en) | 1999-12-01 | 2000-12-01 | Eliciting hcv-specific antibodies |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7329408B2 (enExample) |
| EP (1) | EP1233782B1 (enExample) |
| JP (1) | JP2004500366A (enExample) |
| AT (1) | ATE413190T1 (enExample) |
| AU (1) | AU5442501A (enExample) |
| CA (1) | CA2393251C (enExample) |
| CY (1) | CY1108734T1 (enExample) |
| DE (1) | DE60040755D1 (enExample) |
| DK (1) | DK1233782T3 (enExample) |
| ES (1) | ES2319727T3 (enExample) |
| PT (1) | PT1233782E (enExample) |
| WO (1) | WO2001047551A2 (enExample) |
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| AU1236801A (en) * | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| US7329408B2 (en) * | 1999-12-01 | 2008-02-12 | Novartis Vaccines And Diagnostics, Inc. | Eliciting HCV-specific antibodies |
| AUPQ797700A0 (en) * | 2000-06-06 | 2000-06-29 | Austin Research Institute, The | Vaccine |
| AU2002322358B2 (en) * | 2001-06-29 | 2009-06-18 | Novartis Vaccines And Diagnostics, Inc. | HCV E1E2 vaccine compositions |
| CU23244A1 (es) * | 2001-07-16 | 2007-10-17 | Ct Ingenieria Genetica Biotech | Formulacion vacunal potenciada por la combinacion de un adn con un antigeno |
| CN1582337B (zh) | 2001-10-11 | 2011-12-14 | 默沙东公司 | 丙型肝炎病毒疫苗 |
| AU2003299994A1 (en) | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
| US20050191358A1 (en) * | 2003-01-14 | 2005-09-01 | Derek O' Hagan | Microparticles with adsorbed polynucleotide-containing species |
| WO2004071414A2 (en) * | 2003-02-05 | 2004-08-26 | Genzyme Corporation | Therapeutic anti-hcv (al9) compounds |
| US20040203084A1 (en) * | 2003-04-10 | 2004-10-14 | Doug Levinson | Profiling conformational variants, antibody compositions and methods of using the same |
| EP1622566A4 (en) * | 2003-04-25 | 2008-06-25 | Novartis Vaccines & Diagnostic | COMPOSITIONS WITH CATIONIC MICROTEILS AND HCV E1E2 DNA AND METHOD OF APPLICATION THEREOF |
| CA2528007C (en) * | 2003-06-02 | 2012-03-27 | Chiron Corporation | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| US20060088819A1 (en) * | 2004-05-17 | 2006-04-27 | Chiron Corporation | Truncated hepatitis C virus NS5 domain and fusion proteins comprising same |
| AU2005294805B2 (en) | 2004-05-28 | 2012-02-16 | Oryxe | A mixture for transdermal delivery of low and high molecular weight compounds |
| PT1801209E (pt) | 2004-08-24 | 2011-05-26 | Toray Industries | Arn gen?mico do v?rus humano modificado da hepatite c com capacidade de replica??o aut?noma |
| DE602005027738D1 (de) * | 2004-11-18 | 2011-06-09 | Univ Hiroshima Nat Univ Corp | Verfahren und kit zur expression von protein unter regulation der expression von einer durch genamplifikation gebildeten wiederholungssequenz und transformant |
| JP5405832B2 (ja) * | 2006-01-04 | 2014-02-05 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | Ｈｃｖ特異的なｔ細胞の活性化 |
| JPWO2009014216A1 (ja) | 2007-07-25 | 2010-10-07 | 国立感染症研究所長 | Ｃ型肝炎ウイルス（ｈｃｖ）に対して感染阻害活性を有する抗体およびその用途 |
| CN102596996B (zh) | 2009-10-30 | 2014-06-18 | 东丽株式会社 | 对丙型肝炎病毒(hcv)具有感染抑制活性的抗体及其用途 |
| CA2856565A1 (en) * | 2010-11-26 | 2012-05-31 | The Macfarlane Burnet Institute For Medical Research And Public Health Ltd. | Multimeric hepatitis virus (hcv) envelope 2 (e2) glycoprotein |
| JP6736464B2 (ja) | 2013-08-29 | 2020-08-05 | シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ | 細胞透過性コンジュゲート及びその使用の方法 |
| EP3349717A4 (en) | 2015-09-17 | 2019-04-17 | JRX Biotechnology, Inc. | APPROACHES TO IMPROVE SKIN HYDROGENATION OR HUMIDIFICATION |
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| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| EP0318216B2 (en) * | 1987-11-18 | 2001-08-29 | Chiron Corporation | NANBV diagnostics |
| US5471330A (en) | 1993-07-29 | 1995-11-28 | Honeywell Inc. | Polysilicon pixel electrode |
| EP0773957B1 (en) * | 1994-07-29 | 2005-06-29 | Chiron Corporation | Secreted hepatitis C virus E1/E2 complex obtained from C-terminally truncated E1 and E2 polypeptides |
| WO1996004301A2 (en) | 1994-07-29 | 1996-02-15 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| GB9416671D0 (en) | 1994-08-17 | 1994-10-12 | Biocine Spa | Assay |
| US6019980A (en) * | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| EP0862419B2 (en) * | 1995-11-09 | 2010-11-17 | Microbiological Research Authority | Microencapsulated dna for vaccination and gene therapy |
| US5939400A (en) * | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| WO1998050556A2 (en) | 1997-05-06 | 1998-11-12 | Chiron Corporation | Intracellular production of hepatitis c e1 and e2 truncated polypeptides |
| EP0996730A1 (en) * | 1997-07-18 | 2000-05-03 | Connaught Laboratories Limited | Nucleic acid vaccines encoding g protein of respiratory syncytial virus |
| CA2314934C (en) * | 1997-12-16 | 2006-08-29 | Chiron Corporation | Use of microparticles combined with submicron oil-in-water emulsions |
| AU1236801A (en) | 1999-10-27 | 2001-05-08 | Chiron Corporation | Activation of hcv-specific t cells |
| US7329408B2 (en) * | 1999-12-01 | 2008-02-12 | Novartis Vaccines And Diagnostics, Inc. | Eliciting HCV-specific antibodies |
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2000
- 2000-12-01 US US09/728,423 patent/US7329408B2/en not_active Expired - Lifetime
- 2000-12-01 AT AT00993586T patent/ATE413190T1/de active
- 2000-12-01 WO PCT/US2000/042541 patent/WO2001047551A2/en not_active Ceased
- 2000-12-01 DK DK00993586T patent/DK1233782T3/da active
- 2000-12-01 JP JP2001548141A patent/JP2004500366A/ja active Pending
- 2000-12-01 ES ES00993586T patent/ES2319727T3/es not_active Expired - Lifetime
- 2000-12-01 DE DE60040755T patent/DE60040755D1/de not_active Expired - Lifetime
- 2000-12-01 AU AU54425/01A patent/AU5442501A/en not_active Abandoned
- 2000-12-01 PT PT00993586T patent/PT1233782E/pt unknown
- 2000-12-01 CA CA2393251A patent/CA2393251C/en not_active Expired - Fee Related
- 2000-12-01 EP EP00993586A patent/EP1233782B1/en not_active Expired - Lifetime
-
2007
- 2007-12-13 US US12/001,920 patent/US20080095800A1/en not_active Abandoned
-
2009
- 2009-01-27 CY CY20091100101T patent/CY1108734T1/el unknown
-
2010
- 2010-08-30 US US12/871,035 patent/US20110159039A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU5442501A (en) | 2001-07-09 |
| ES2319727T3 (es) | 2009-05-12 |
| US20080095800A1 (en) | 2008-04-24 |
| PT1233782E (pt) | 2009-02-13 |
| US7329408B2 (en) | 2008-02-12 |
| EP1233782A2 (en) | 2002-08-28 |
| CA2393251A1 (en) | 2001-07-05 |
| EP1233782B1 (en) | 2008-11-05 |
| WO2001047551A3 (en) | 2002-03-14 |
| JP2004500366A (ja) | 2004-01-08 |
| CY1108734T1 (el) | 2014-04-09 |
| ATE413190T1 (de) | 2008-11-15 |
| WO2001047551A2 (en) | 2001-07-05 |
| US20110159039A1 (en) | 2011-06-30 |
| US20020002272A1 (en) | 2002-01-03 |
| DK1233782T3 (da) | 2009-02-09 |
| DE60040755D1 (de) | 2008-12-18 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20151201 |