CA2390530A1 - Amines de n-aryl-(homopiperazinyl)-cyclohexyl, utilisees comme transporteurs de 5-ht - Google Patents

Amines de n-aryl-(homopiperazinyl)-cyclohexyl, utilisees comme transporteurs de 5-ht Download PDF

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Publication number
CA2390530A1
CA2390530A1 CA002390530A CA2390530A CA2390530A1 CA 2390530 A1 CA2390530 A1 CA 2390530A1 CA 002390530 A CA002390530 A CA 002390530A CA 2390530 A CA2390530 A CA 2390530A CA 2390530 A1 CA2390530 A1 CA 2390530A1
Authority
CA
Canada
Prior art keywords
carbon atoms
alkyl
compound
cyano
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002390530A
Other languages
English (en)
Inventor
Adam Matthew Gilbert
Richard Eric Mewshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2390530A1 publication Critical patent/CA2390530A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention se rapporte à de nouveaux composés et à de nouveaux procédés, ainsi qu'à des compositions utilisant ces composés et ces procédés dans le traitement des troubles du système nerveux central, tels que la dépression et l'anxiété, ces composés étant représentés par la formule (I), où Ar représente un aryle, un arylalkyle ou un groupe hétéroaryle; R¿1? et R¿2? sont choisis séparément parmi hydrogène, alkyle de 1 à 12 atomes de carbone pouvant être substitué ou cycloalkyle de 3 à 10 atomes de carbone pouvant être substitué; R¿3? représente H, alkyle pouvant être substitué, alkyle cyclique pouvant être substitué, halogène, alcoxy, haloalkyle, OH, nitro, amino, CN, carboxy, alcoxycarbonyle, alkylcarbonyle, aminocarbonyle et alkylaminocarbonyle; et à un sel de ces composés acceptable sur le plan pharmaceutique.
CA002390530A 1999-11-08 2000-05-19 Amines de n-aryl-(homopiperazinyl)-cyclohexyl, utilisees comme transporteurs de 5-ht Abandoned CA2390530A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43612999A 1999-11-08 1999-11-08
US09/436,129 1999-11-08
PCT/US2000/014020 WO2001034597A1 (fr) 1999-11-08 2000-05-19 Amines de n-aryl-(homopiperazinyl)-cyclohexyl, utilisees comme transporteurs de 5-ht

Publications (1)

Publication Number Publication Date
CA2390530A1 true CA2390530A1 (fr) 2001-05-17

Family

ID=23731225

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002390530A Abandoned CA2390530A1 (fr) 1999-11-08 2000-05-19 Amines de n-aryl-(homopiperazinyl)-cyclohexyl, utilisees comme transporteurs de 5-ht

Country Status (8)

Country Link
EP (1) EP1228064A1 (fr)
JP (1) JP2003513969A (fr)
CN (1) CN1420883A (fr)
AU (1) AU5152300A (fr)
BR (1) BR0015425A (fr)
CA (1) CA2390530A1 (fr)
MX (1) MXPA02004554A (fr)
WO (1) WO2001034597A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
SE0103648D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinolone compounds
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
AU5311098A (en) * 1996-12-20 1998-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives

Also Published As

Publication number Publication date
MXPA02004554A (es) 2004-09-10
EP1228064A1 (fr) 2002-08-07
CN1420883A (zh) 2003-05-28
BR0015425A (pt) 2002-07-16
WO2001034597A1 (fr) 2001-05-17
AU5152300A (en) 2001-06-06
JP2003513969A (ja) 2003-04-15

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