CA2388342A1 - Composition for restoring defects in calcified tissues - Google Patents

Composition for restoring defects in calcified tissues Download PDF

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Publication number
CA2388342A1
CA2388342A1 CA002388342A CA2388342A CA2388342A1 CA 2388342 A1 CA2388342 A1 CA 2388342A1 CA 002388342 A CA002388342 A CA 002388342A CA 2388342 A CA2388342 A CA 2388342A CA 2388342 A1 CA2388342 A1 CA 2388342A1
Authority
CA
Canada
Prior art keywords
calcium
silicate
source
solution
amorphous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002388342A
Other languages
French (fr)
Other versions
CA2388342C (en
Inventor
Gregory P. Dodd
Alan A. Halecky
Kenneth J. Markowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Block Drug Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2388342A1 publication Critical patent/CA2388342A1/en
Application granted granted Critical
Publication of CA2388342C publication Critical patent/CA2388342C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/77—Glass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/807—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising magnesium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/816—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising titanium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/824—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising transition metal oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/853—Silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Silicon Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A composition for restoring defects in calcified tissues comprises an amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen. Said agent may be selected from the group consisting of : a) a reaction product of an organic silicate source and a source of calcium; b) a calcium containing hydrolysis product of tetraethylorthosilicate; c) a calcium containing silica sol-gel; d) a binary calcium oxide and silicate precipitated material; e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of soluble calcium source and a silicate solution. A process for producing the amorphous bioactive particulate consists essentially of adding a sufficient amount of a solution of a soluble calcium source to a solution of a silicate or silicate precursor to cause a precipitation of calcium-containing silicate particulate.

Claims (20)

1. A composition for restoring defects in calcified tissues comprising an amorphous bioactive particulate material consisting essentially of calcium, silicon and oxygen.
2. A composition according to claim 1 wherein said amorphous material is selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
3. A composition according to claim 2 wherein said amorphous material is a precipitated reaction product of a soluble calcium source and a dilute silicate source selected from an aqueous potassium solution or a sodium silicate solution.
4. A composition according to any of claims 1 to 3, in which the said material has a particle size in the range of about 10 microns or less.
5. A composition according to claim 4, in which the material mostly comprises particles in the size range of about 2 microns or less.
6. A composition according to any of claims 1 to 5 in a dental product to alleviate tooth sensitivity due to the presence of exposed dentinal surface and open dentinal tubules, by causing the formation of calcium containing mineral within dentinal tubules of the sensitive teeth.
7. A composition according to claim 6 comprising a carrier and about 1-25% of said amorphous material.
8. A composition according to claim 7 wherein the carrier comprises 0-30%
water, 0-90%
glycerol and 0-80% sorbitol.
9. A composition according to claim 7 or claim 8 wherein said amorphous material is about 5-10% of the composition and the composition is a dentifrice.
10. Use of an amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen, in the preparation of product to restore defects in calcified tissues.
11. A use according to claim 10 in the preparation of product to alleviate tooth sensitivity due to the presence of exposed dentinal surface and open dentinal tubules by causing the formation of calcium containing mineral within dentinal tubules of the sensitive teeth.
12. A use according to claim 10 or claim 11 wherein said amorphous material is selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
13. An amorphous bioactive particulate consisting essentially of calcium, silicon and oxygen, for restoring defects in calcified tissues.
14. An amorphous bioactive particulate according to claim 13, for use in the desensitizing of teeth.
15. An amorphous bioactive particulate according to claim 13 or claim 14 selected from the group consisting of:
a) a reaction product of an organic silicate source and a source of calcium;
b) a calcium containing hydrolysis product of tetraethylorthosilicate;
c) a calcium containing silica sol-gel;
d) a binary calcium oxide and silicate precipitated material;
e) a synthetic analog of a naturally occurring wollastonite-like calcium silicate; and f) a precipitated reaction product of a soluble calcium source and a silicate solution.
16. A process for producing an amorphous bioactive particulate for restoring defects in calcified tissues, said process consisting essentially of adding a sufficient amount of a solution of a soluble calcium source to a solution of a silicate or silicate precursor to cause a precipitation of calcium-containing silicate particulates.
17. A process according to claim 16, wherein said soluble calcium source is selected from the group consisting of calcium salts and alkoxide derivatives and mixtures thereof.
18. A process according to claim 16 or claim 17, wherein said solution of a silicate or silicate precursor is a dilute silicate source selected from the group of aqueous potassium solution and aqueous sodium silicate solution.
19. A process for the production of an amorphous bioactive particulate for the treatment of sensitive teeth, said process consisting essentially of combining a metal alkoxide with water and a catalyst and polymerization of a silicate ester for the production of said amorphous bioactive particulate.
20. A process according to claim 19, wherein said metal alkoxide is prepared from tetraethoxysilane and silanol terminated poly(dimethylsiloxane).
CA2388342A 1999-08-05 2000-08-04 Composition for restoring defects in calcified tissues Expired - Fee Related CA2388342C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14743899P 1999-08-05 1999-08-05
US60/147,438 1999-08-05
US09/419,514 US20020037258A1 (en) 1999-08-05 1999-10-18 Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth
US09/419,514 1999-10-18
PCT/GB2000/003015 WO2001010392A2 (en) 1999-08-05 2000-08-04 Composition for restoring defects in calcified tissues

Publications (2)

Publication Number Publication Date
CA2388342A1 true CA2388342A1 (en) 2001-02-15
CA2388342C CA2388342C (en) 2010-09-14

Family

ID=26844940

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2388342A Expired - Fee Related CA2388342C (en) 1999-08-05 2000-08-04 Composition for restoring defects in calcified tissues

Country Status (17)

Country Link
US (1) US20020037258A1 (en)
EP (1) EP1202705B1 (en)
JP (1) JP2003506391A (en)
KR (1) KR20020032546A (en)
CN (1) CN1377252A (en)
AT (1) ATE380012T1 (en)
AU (1) AU6455700A (en)
BR (1) BR0012971A (en)
CA (1) CA2388342C (en)
CZ (1) CZ2002438A3 (en)
DE (1) DE60037319T2 (en)
EA (1) EA200200115A1 (en)
ES (1) ES2296631T3 (en)
HU (1) HUP0203667A2 (en)
PL (1) PL364721A1 (en)
PT (1) PT1202705E (en)
WO (1) WO2001010392A2 (en)

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Also Published As

Publication number Publication date
EP1202705B1 (en) 2007-12-05
DE60037319T2 (en) 2008-11-27
EA200200115A1 (en) 2002-06-27
CZ2002438A3 (en) 2002-08-14
CN1377252A (en) 2002-10-30
HUP0203667A2 (en) 2003-04-28
ATE380012T1 (en) 2007-12-15
DE60037319D1 (en) 2008-01-17
CA2388342C (en) 2010-09-14
US20020037258A1 (en) 2002-03-28
JP2003506391A (en) 2003-02-18
PL364721A1 (en) 2004-12-13
WO2001010392A2 (en) 2001-02-15
ES2296631T3 (en) 2008-05-01
BR0012971A (en) 2002-04-30
PT1202705E (en) 2008-02-25
EP1202705A2 (en) 2002-05-08
AU6455700A (en) 2001-03-05
WO2001010392A3 (en) 2001-07-05
KR20020032546A (en) 2002-05-03

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