CN102908663A - Silicon-atom and apatite doped composite high-polymer material and preparation method thereof - Google Patents
Silicon-atom and apatite doped composite high-polymer material and preparation method thereof Download PDFInfo
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- CN102908663A CN102908663A CN2012104124358A CN201210412435A CN102908663A CN 102908663 A CN102908663 A CN 102908663A CN 2012104124358 A CN2012104124358 A CN 2012104124358A CN 201210412435 A CN201210412435 A CN 201210412435A CN 102908663 A CN102908663 A CN 102908663A
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Abstract
The invention discloses a silicon-atom and apatite doped composite high-polymer material. The silicon-atom and apatite doped composite high-polymer material comprises, by weight, 100 parts of apatite, 2-30 parts of chlorosilane, 10-20 parts of phosphoric acid, 2-10 parts of potassium hydroxide and 10-15 parts of hyaluronic acid. The silicon-atom and apatite doped composite high-polymer material is high in activity and restoring capability for skeleton.
Description
Technical field
The present invention relates to macromolecular material, belong to Material Field.
Background technology
The composition of skeleton is mainly apatite and macromolecule glue fibril, and synthetic also mainly the following take natural bone composition material as main one-tenth of bone repair material closed method.
In recent years, the Silicon-Substituted Hydroxyapatite that occurs knowing clearly is material modified, all adopts silicon is incorporated in the lattice of hydroxyapatite, thereby makes lattice form defective and disproportionation, improves its reactivity in the implantable bioartificial body.But from whole preparation process, no matter be wet method or dry method, all element silicon and apatite are formed the homogeneous phase doping, carry out high-temperature calcination, but the hydroxy apatite powder of preparing agglomeration in the process of dry and powder face burning is serious, crystal increases thick increase, differs greatly with weak crystal type nano osteolith structure in the skeleton, has reduced biological activity and interfacial reaction active.
The patent No. is to have proposed a kind of new method in the patent documentation of ZL200810233572, it is the bone renovating material of the method preparation of nanometer hydroxyapatite surface coated silica, it is low that the made repair materials silicon atom of this method carries out the apatite crystalline grain rate, therefore, its activity neither be very high, and its preparation method is complicated, and yield rate is low, cost is high, can't satisfy the requirement of industrialization.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defective, and the silicon atom Doping Phosphorus lime stone composite high-molecular material that a kind of activity is strong, the bone repair ability is strong is provided;
Another object of the present invention provides a kind of simple to operate, the preparation method of the silicon atom Doping Phosphorus lime stone composite high-molecular material that yield rate is high.
Purpose of the present invention is come specific implementation by the following technical programs:
A kind of silicon atom Doping Phosphorus lime stone composite high-molecular material, raw material components by weight, 100 parts in apatite, chlorosilane 2-30 part, phosphatase 11 0-20 part, potassium hydroxide 2-10 part, hyaluronic acid 10-15 part.
As preferred version, above-mentioned silicon atom Doping Phosphorus lime stone composite high-molecular material, raw material components by weight, 100 parts in apatite, 25 parts of chlorosilanes, 5 parts of phosphatase 11s, 3 parts of potassium hydroxide, 15 parts of hyaluronic acids.
The preparation method of above-mentioned silicon atom Doping Phosphorus lime stone composite high-molecular material comprises the steps,
Step 1, with apatite and phosphoric acid, potassium hydroxide mix homogeneously, drying;
Step 2, the material after step 1 is processed fully mix with chlorosilane, hyaluronic acid, put into high temperature reaction stove, take out furnace air after, in high temperature reaction stove, pass into noble gas protection, be warming up to 1000-1500 ℃, more than the isothermal reaction 2min;
After step 3, reaction finish, drop to room temperature in inert gas shielding, obtain silicon atom Doping Phosphorus lime stone composite high-molecular material.
Preferably, heating-up temperature is 1200 ℃ in the described step 1, keeps 2 min.
Preferably, described noble gas adopts argon.
Beneficial effect of the present invention:
Silicon atom Doping Phosphorus lime stone composite high-molecular material provided by the present invention is active strong, and is strong to the bone repair ability; The preparation method of silicon atom Doping Phosphorus lime stone composite high-molecular material provided by the present invention is carried out activation processing to apatite first, doping reaction and one step of synthesis of polymer material is finished again, and is simple to operate, is suitable for suitability for industrialized production.
The specific embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein only is used for description and interpretation the present invention, is not intended to limit the present invention.
Embodiment 1:
A kind of silicon atom Doping Phosphorus lime stone composite high-molecular material is pressed table 1 indication composition of raw materials, and its preparation method is as follows:
Step 1, with apatite and phosphoric acid, potassium hydroxide mix homogeneously, drying;
Step 2, the material after step 1 is processed fully mix with chlorosilane, hyaluronic acid, put into high temperature reaction stove, take out furnace air after, in high temperature reaction stove, pass into argon protection, be warming up to 1200 ℃, isothermal reaction 2min;
After step 3, reaction finish, drop to room temperature in argon shield, obtain silicon atom Doping Phosphorus lime stone composite high-molecular material.
Embodiment 2:
A kind of silicon atom Doping Phosphorus lime stone composite high-molecular material is pressed table 1 indication composition of raw materials, and its preparation method is as follows:
Step 1, with apatite and phosphoric acid, potassium hydroxide mix homogeneously, drying;
Step 2, the material after step 1 is processed fully mix with chlorosilane, hyaluronic acid, put into high temperature reaction stove, take out furnace air after, in high temperature reaction stove, pass into argon protection, be warming up to 1000 ℃, isothermal reaction 10min;
After step 3, reaction finish, drop to room temperature in argon shield, obtain silicon atom Doping Phosphorus lime stone composite high-molecular material.
Embodiment 3:
A kind of silicon atom Doping Phosphorus lime stone composite high-molecular material is pressed table 1 indication composition of raw materials, and its preparation method is as follows:
Step 1, with apatite and phosphoric acid, potassium hydroxide mix homogeneously, drying;
Step 2, the material after step 1 is processed fully mix with chlorosilane, hyaluronic acid, put into high temperature reaction stove, take out furnace air after, in high temperature reaction stove, pass into argon protection, be warming up to 1500 ℃, isothermal reaction 3min;
After step 3, reaction finish, drop to room temperature in argon shield, obtain silicon atom Doping Phosphorus lime stone composite high-molecular material.
The above only is the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment the present invention is had been described in detail, for a person skilled in the art, it still can be made amendment to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. silicon atom Doping Phosphorus lime stone composite high-molecular material is characterized in that: raw material components by weight, 100 parts in apatite, chlorosilane 2-30 part, phosphatase 11 0-20 part, potassium hydroxide 2-10 part, hyaluronic acid 10-15 part.
2. silicon atom Doping Phosphorus lime stone composite high-molecular material according to claim 1 is characterized in that: raw material components by weight, 100 parts in apatite, 25 parts of chlorosilanes, 5 parts of phosphatase 11s, 3 parts of potassium hydroxide, 15 parts of hyaluronic acids.
3. the preparation method of silicon atom Doping Phosphorus lime stone composite high-molecular material according to claim 1 and 2 is characterized in that: comprises the steps,
Step 1, with apatite and phosphoric acid, potassium hydroxide mix homogeneously, drying;
Step 2, the material after step 1 is processed fully mix with chlorosilane, hyaluronic acid, put into high temperature reaction stove, take out furnace air after, in high temperature reaction stove, pass into noble gas protection, be warming up to 1000-1500 ℃, more than the isothermal reaction 2min;
After step 3, reaction finish, drop to room temperature in inert gas shielding, obtain silicon atom Doping Phosphorus lime stone composite high-molecular material.
4. the preparation method of silicon atom Doping Phosphorus lime stone composite high-molecular material according to claim 3, it is characterized in that: heating-up temperature is 1200 ℃ in the described step 1, keeps 2 min.
5. the preparation method of silicon atom Doping Phosphorus lime stone composite high-molecular material according to claim 3 is characterized in that: described noble gas employing argon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2012104124358A CN102908663A (en) | 2012-10-25 | 2012-10-25 | Silicon-atom and apatite doped composite high-polymer material and preparation method thereof |
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| CN2012104124358A CN102908663A (en) | 2012-10-25 | 2012-10-25 | Silicon-atom and apatite doped composite high-polymer material and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020037258A1 (en) * | 1999-08-05 | 2002-03-28 | Gregory P. Dodd | Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth |
| WO2004044274A1 (en) * | 2002-11-13 | 2004-05-27 | Cambridge University Technical Services Limited | A synthetic bone material |
| CN101433734A (en) * | 2008-11-17 | 2009-05-20 | 昆明理工大学 | Method for synthesizing nano hydroxylapatite material with biological activity |
| CN101954119A (en) * | 2010-09-10 | 2011-01-26 | 北京化工大学 | Method for preparing light-cured bone repair material from double bond-containing siloxane coated and modified hydroxyapatite |
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2012
- 2012-10-25 CN CN2012104124358A patent/CN102908663A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020037258A1 (en) * | 1999-08-05 | 2002-03-28 | Gregory P. Dodd | Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth |
| WO2004044274A1 (en) * | 2002-11-13 | 2004-05-27 | Cambridge University Technical Services Limited | A synthetic bone material |
| CN101433734A (en) * | 2008-11-17 | 2009-05-20 | 昆明理工大学 | Method for synthesizing nano hydroxylapatite material with biological activity |
| CN101954119A (en) * | 2010-09-10 | 2011-01-26 | 北京化工大学 | Method for preparing light-cured bone repair material from double bond-containing siloxane coated and modified hydroxyapatite |
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