CN107157785A - A kind of remineralization of teeth toothpaste and preparation method thereof - Google Patents
A kind of remineralization of teeth toothpaste and preparation method thereof Download PDFInfo
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- CN107157785A CN107157785A CN201710353596.7A CN201710353596A CN107157785A CN 107157785 A CN107157785 A CN 107157785A CN 201710353596 A CN201710353596 A CN 201710353596A CN 107157785 A CN107157785 A CN 107157785A
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- remineralization
- wollastonite
- teeth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Abstract
The invention belongs to oral care techniques field, a kind of remineralization of teeth toothpaste is specifically disclosed, the raw material components of following percentage by weight are included：Wollastonite 3 5%, rubbing agent 20 60%, purificant 0.5 2%, wetting agent 20 40%, adhesive 1 5%, remaining is water.Its preparation method comprises the following steps：Adhesive is added in wetting agent first, is uniformly mixed, obtains mixture A；Then wollastonite, purificant are dissolved in the water, are uniformly mixed, obtain mixture B；Finally mixture A and mixture B are well mixed, and add rubbing agent, stirs, produces.The remineralization of teeth toothpaste of the present invention can have the effect of closing dentinal tubule and induction Enamel remineralizations concurrently, can be effectively improved carious tooth, be inherently eliminated hypersensitive dentin symptom.
Description
Technical field
The present invention relates to oral care techniques field, more particularly to a kind of remineralization of teeth toothpaste and preparation method thereof.
Background technology
Tooth is the important organ of mastication of the mankind, and has effects that to assist pronunciation and keep face well-done.The master of tooth
Body is Dentin Structure, and including in the dentinal tubule of many queueing disciplines, pipe has nerve fibre, can perceive external irritant.Cover
It is calcified tissue most hard in human body to be placed on the enamel on the outside of dentine, mainly comprising inorganic salts ingredients such as calcium phosphate, should
Tissue can effectively obstruct the external irritant such as hot and cold, sour, play a part of taking care of one's teeth.When generation carious tooth or due to other factorses
(such as hypoplasia of enamel, unilateral tooth wear are serious) causes enamel to be destroyed, dentine exposure, in dentinal tubule
Nerve fibre is with regard to that can perceive environmental stimuli so as to cause dental pain, i.e. dental hypersensitivity.
The therapeutic strategy of current dental hypersensitiveness focuses primarily upon laser, medicine two kinds of forms of desensitization, wherein with medicine
Desensitization is most widely used.The therapeutic strategy of medicine desensitization is by closing dentinal tubule, blocking the god in dentinal tubule
Liquid through conducting and reducing in dentinal tubule flows to realize desensitization purpose.
Traditional anti-caries agent is generally fluoride, and when mineral are lost in early stage, fluorine ion can improve the acid-resisting of enamel simultaneously
Clogged with deposits dentinal tubule is formed, so as to mitigate the appearance of hypersensitive dentin symptom, while there are some researches show fluorine ion can
To induce the remineralization of enamel, the function that enamel is independently repaired is realized.But use the preventing and treating mesh of fluoride progress carious tooth
It is preceding to there is larger dispute, fluorosis or children are lived in because swallowing reflex is poor mainly due to people, are easily being brushed teeth
Mistiming may result in fluorine ion High accumulation after gulping down the reason Excess free enthalpy fluoride such as toothpaste, ultimately form den tal fluorosis --- in tooth
Tooth surface forms inhomogenous color even indenture and yellowish-brown spot.Therefore,《Chinese residents oral health guide》In it is bright
Really point out that fluorosis is not suitable for carrying out preventing decayed tooth desensitization treatment using toothpaste with fluoride.
In recent years, strontium chloride turns into most commonly used anti-caries desensitizer after i.e. fluoride, and strontium has to all calcified tissues
Powerful adsorptivity, can block dentinal tubule by forming saamite.But fluoride effect is compared, strontium chloride can not
The remineralization of enamel is induced, the effect of " curing the symptoms, not the disease " can only be played to hypersensitive dentin.And other types of desensitizer,
Such as composition containing potassium nitrate, is only capable of reducing the excitability of nerve fibre tip, pain is alleviated in a short time, not
Fundamentally exposed dentinal tubule is closed, enamel decalcification is prevented.
The content of the invention
For problems of the prior art, it is an object of the invention to provide a kind of remineralization of teeth toothpaste and its system
Preparation Method, the toothpaste can have the effect of closing dentinal tubule and induction Enamel remineralizations concurrently, can be effectively improved carious tooth, disappear
Except hypersensitive dentin symptom.
In order to achieve the above object, the present invention is achieved using following technical scheme.
(1) a kind of remineralization of teeth toothpaste, it is characterised in that include the raw material components of following percentage by weight：Wollastonite
3-5%, rubbing agent 20-60%, purificant 0.5-2%, wetting agent 20-40%, adhesive 1-5%, remaining is water.
Preferably, the wollastonite is wollastonite microballoon.
It is further preferred that a diameter of 1.0-3.0 μm of the wollastonite microballoon.
Preferably, the wollastonite microballoon is prepared according to following steps：Natural wollastonite is taken, respectively with deionized water and nothing
After water-ethanol centrifuge washing, it is placed in baking oven and dries, grinds to obtain natural wollastonite powder, aqueous gelatin solution is added thereto, is stirred
Mix, and washed successively with acetone and absolute ethyl alcohol, is finally freeze-dried, high temperature sintering is produced.
Preferably, the rubbing agent includes silica, calcium pyrophosphate, sodium metaphosphate or calcium carbonate.
Preferably, the purificant is surfactant, includes Determination of Polyoxyethylene Non-ionic Surfactants or both sexes table
Face activating agent.
It is further preferred that the Determination of Polyoxyethylene Non-ionic Surfactants is polysorbate 20 or PEG-40 hydrogenation castors
Sesame oil.
It is further preferred that the amphoteric surfactant is cocamidopropyl betaine or lauryl glucoside
Glycosides.
Preferably, the wetting agent is glycerine, sorbierite or propane diols.
Preferably, the adhesive is sodium carboxymethylcellulose.
Preferably, one kind or several in the remineralization of teeth toothpaste also raw material components comprising following percentage by weight
Kind：Aromatic 1-3%, preservative 1-3%, colouring agent 1-3%.
(2) preparation method of remineralization of teeth toothpaste, it is characterised in that comprise the following steps：
Step 1, adhesive is added in wetting agent, is uniformly mixed, obtains mixture A；
Step 2, wollastonite, purificant are dissolved in the water, are uniformly mixed, obtain mixture B；
Step 3, mixture A and mixture B are well mixed, and add rubbing agent, stirred, produce.
Silicon ash stone material has good biocompatibility, bioactivity and higher mineralization ability, from elementary analysis
On see, contained Ca, Mg are the essential elements needed for sclerous tissues's mineralising in Wollastonite composition, and Si is then animal and human body
A kind of important trace element in tissue, and early stage calcifications of the Si to sclerous tissues is most important.
The invention provides a kind of remineralization of teeth toothpaste using wollastonite as raw material components, materials safety effectively, makes
During with the toothpaste, mineralising reaction can occur after dentinal tubule is entered for wollastonite, block the dentinal tubule of exposure, promote
The deposition of dental surface mineral matter, induces the remineralization of carious tooth, repairing dental enamel structure；The antiallergy and rush tooth of the present invention is again
The toothpaste of mineralising has the effect of closing dentinal tubule and induction Enamel remineralizations concurrently, with being effectively improved carious tooth, from basic
The upper advantage for eliminating hypersensitive dentin symptom.
Brief description of the drawings
The present invention is described in further details with specific embodiment below in conjunction with the accompanying drawings.
Fig. 1 is the scanning of dentinal tubule of the exposure dentine piece after toothpaste processing prepared by embodiment 1 and embodiment 2
Electron microscope；In figure, A is control group, 1000 times of amplifications；B is 1 group of embodiment, 1000 times of amplifications；C is 2 groups, 1000 times of embodiment
Amplification；D is control group, 3000 times of amplifications；E is 1 group of embodiment, 3000 times of amplifications；F is 2 groups of embodiment, 3000 times of amplifications；
Fig. 2 is the scanning electricity of dentinal tubule of the demineralization dentine after toothpaste processing prepared by embodiment 1 and embodiment 2
5000 times of enlarged drawings of mirror；In figure, A is control group, and B is demineralization dentine group；C is 1 group of embodiment, and D is 2 groups of embodiment；
Fig. 3 is scanning electron microscope (SEM) photograph of the demineralization enamel after toothpaste processing prepared by embodiment 1 and embodiment 2；In figure, A
For demineralization enamel group, 1000 times of amplifications；B is 1 group of embodiment, 1000 times of amplifications；C is 2 groups of embodiment, 1000 times of amplifications；D is
Demineralization enamel group, 3000 times of amplifications；E is 1 group of embodiment, 3000 times of amplifications；F is 2 groups of embodiment, 3000 times of amplifications；G is de-
Ore deposit enamel group, 5000 times of amplifications；H is 1 group of embodiment, 5000 times of amplifications；I is 2 groups of embodiment, 5000 times of amplifications.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
It will be appreciated that the following example is merely to illustrate the present invention, and it is not construed as limiting the scope of the present invention.
Embodiment 1
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 3%, silica 20%, polysorbate 20 0.5%, glycerine 20%, sodium carboxymethylcellulose 1%, its
Remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose is added in glycerine, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and polysorbate 20 are dissolved in distilled water, are uniformly mixed, obtain mixture B；
Wherein, a diameter of 2.0 μm of wollastonite microballoon, are followed the steps below：Natural wollastonite is taken, respectively with deionized water and nothing
Water-ethanol after centrifuge washing 3 times, is placed in 60 DEG C of baking oven and dried, day is obtained using corundum mortar grinder under the conditions of the 3000rpm
Right wollastonite powder, adds the aqueous gelatin solution that mass concentration is 10%, is sufficiently stirred under the conditions of 50 DEG C 1 hour thereto,
Obtain turbid solution；Turbid solution is mixed in the vegetable oil under ice bath, and disperses it with 200rpm rotating speed, successively with acetone and nothing
Water-ethanol is washed, and is then freeze-dried under the conditions of -20 DEG C, finally the high temperature sintering 2h under the conditions of 1200 DEG C, produces natural silicon
Lime stone microballoon；
Step 3, mixture A and mixture B are well mixed, and add silica, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 2
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 5%, silica 20%, polysorbate 20 0.5%, glycerine 20%, sodium carboxymethylcellulose 1%, its
Remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose is added in glycerine, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and polysorbate 20 are dissolved in distilled water, are uniformly mixed, obtain mixture B；
Wherein, a diameter of 2.0 μm of wollastonite microballoon, its preparation method be the same as Example 1；
Step 3, mixture A and mixture B are well mixed, and add silica, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 3
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 4%, silica 40%, Polyoxamer407 2%, glycerine 40%, sodium carboxymethylcellulose 3%,
Remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose is added in glycerine, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and polysorbate 20 are dissolved in distilled water, are uniformly mixed, obtain mixture B；
Wherein, a diameter of 2.0 μm of wollastonite microballoon, its preparation method be the same as Example 1；
Step 3, mixture A and mixture B are well mixed, and add silica, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 4
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 3%, sodium metaphosphate 20%, Cremophor RH40 0.5%, propane diols 20%, carboxymethyl cellulose
Sodium 1%, remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose is added in propane diols, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and Cremophor RH40 are dissolved in distilled water, are uniformly mixed, obtain mixed
Compound B；Wherein, a diameter of 2.0 μm of wollastonite microballoon, its preparation method be the same as Example 1；
Step 3, mixture A and mixture B are well mixed, and add sodium metaphosphate, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 5
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 5%, calcium carbonate 40%, lauryl glucosyl 2%, sorbierite 30%, sodium carboxymethylcellulose
3%, remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose is added in sorbierite, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and lauryl glucosyl are dissolved in distilled water, are uniformly mixed, obtain mixed
Compound B；Wherein, a diameter of 2.0 μm of wollastonite microballoon, its preparation method be the same as Example 1；
Step 3, mixture A and mixture B are well mixed, and add calcium carbonate, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 6
The present embodiment provides a kind of remineralization of teeth toothpaste, includes the raw material components of following percentage by weight：A diameter of 2.0
μm wollastonite microballoon 4%, calcium pyrophosphate 60%, cocamidopropyl betaine 1.5%, glycerine 30%, carboxymethyl cellulose
Plain sodium 5%, sodium benzoate 1%, remaining is distilled water.
The preparation method of above-mentioned toothpaste comprises the following steps：
Step 1, sodium carboxymethylcellulose and sodium benzoate are added in glycerine, is uniformly mixed, obtains mixture A；
Step 2, wollastonite microballoon and cocamidopropyl betaine are dissolved in distilled water, are uniformly mixed,
Obtain mixture B；Wherein, a diameter of 2.0 μm of wollastonite microballoon, its preparation method be the same as Example 1；
Step 3, mixture A and mixture B are well mixed, and add calcium pyrophosphate, stir to obtain homogeneous colloids, vacuum takes off
Gas, sterilizing, are produced.
Embodiment 7
The toothpaste that above-described embodiment 1 and embodiment 2 are prepared is applied to the experimental study to exposure dentin mineralization,
Used investigation object is the dentine piece for meeting sensitivity of tooth in vitro study in the present embodiment.
(1) preparation of dentine piece：Collected in Stomatological Hospital, Military Surgeon Univ. No. 4's decorative sursery outpatient service because of orthodontic treatment (year
Age span 18-28 Sui, corona is complete, without dental caries are bad, flawless, without treatment of restoration nature) and the premolar teeth pulled out and 20 (trouble of grinding one's teeth in sleep
Person's informed consent), under crown portion dento enamel junction at about 1.5mm, using SYJ-150 low-speed diamond cutting machines parallel to stinging
(Shenyang Ke Jing automation equipments Manufacturing Co., Ltd) is cut in conjunction face, obtains the thick dentine pieces of about 2.0mm.Through silicon carbide paper
Sanding and polishing dentine piece occlusion surface side to thickness is about 1.5mm step by step, ultimately forms flat smooth surface.Use clinic use
37% phosphoric acid gel acid etching dentine piece 1min, a large amount of deionized water rinsings remove flaw after ultrasound shake 20min in deionized water
Pollution layer exposes dentinal tubule, and simulation enamel strips off rear dentinal tubule exposure in oral cavity, and it is quick that acquisition meets dentine
Feel the dentine piece (normal dentine group) of research.
(2) toothpaste processing dentine piece prepared by embodiment 1 and embodiment 2 is respectively adopted, 1 group of embodiment and implementation is obtained
2 groups of example, is comprised the following steps that：Dentine piece is fixed on slide with tweezers, 5.0g embodiments 1 and embodiment are weighed respectively
Toothpaste slurries are made in the 2 toothpaste samples prepared, plus the stirring of 10.0g deionized waters, are coated on whole dentine piece surface, use fur
Toothbrush gently brushes 2min manually, quiet to put 2min；Then, with 20mL deionized water rinsings 3 times, it is put into 10mL artificial salivas and soaks,
Fresh artificial saliva is changed daily, and is deposited in 37 DEG C of insulating boxs；Processing dentine sample 2 times, and the 2nd processing daily
Afterwards, in 37 DEG C of artificial salivas overnight.Scrubbed as a control group with toothpaste conventional on the market, operating method is ibid；Continuous place
After the toothpaste sample 14d for managing 1 group of embodiment, 2 groups of embodiment and control group, laggard glutaraldehyde is spontaneously dried in air and is fixed, sprayed
Gold, SEM observations.
(3) result of the test
Using dentine of the scanning electron microscopic observation dentine piece after toothpaste processing prepared by the present embodiment 1 and embodiment 2
The blocking effect of tubule, as a result as shown in Figure 1.
From the A figures and D figures in Fig. 1, the dentinal tubule of control group is hollow, has no that any tamper is present, Guan Jian
Dentine boundary clear；From the B figures and E figures in Fig. 1,1 group of visible dentinal tubule of embodiment is blocked by paste material,
Dentine wiring is unintelligible between sediment and pipe；From the C figures and F figures in Fig. 1,2 groups of visible dentinal tubules of embodiment are equal
Blocked by paste material, material exquisiteness is homogeneous, dentine boundary is smudgy between sediment and pipe.
Embodiment 8
The toothpaste that above-described embodiment 1 and embodiment 2 are prepared is applied to it and the external of demineralization dentin mineralization is ground
Study carefully, used investigation object is the dentine piece for meeting sensitivity of tooth in vitro study in the present embodiment.
(1) preparation of dentine piece：Be the same as Example 7.
(2) using clinical with 37% phosphoric acid gel acid etching dentine piece 1min, a large amount of deionized water rinsings are after deionization
Ultrasound shake 20min, removes smear layer exposure dentinal tubule (control group) in water.It is random to take out 4 dentine pieces progress surface sweepings
Electron microscopic observation, is shown in that smear layer is removed completely, and the non-demineralization of dentine (scheming referring to A in Fig. 2) between pipe.By remaining dentine piece again
With clinical 37% phosphoric acid gel acid etching dentine piece 1min, a large amount of deionized water rinsings are after ultrasound shake in deionized water
20min, simulation dentine is exposed to the demineralization after oral environment and changed for a long time, obtains the dentine for meeting dentine demineralization research
Piece (demineralization dentine group).The specific steps of toothpaste processing dentine piece sample prepared by embodiment 1 and embodiment 2 are respectively adopted
Be the same as Example 7, respectively as 2 groups of 1 group of embodiment and embodiment；The sample of 1 group of embodiment, 2 groups of embodiment and control group is connected
Continuous processing 14d, 2 times a day, each 2min；Carry out glutaraldehyde after spontaneously drying in atmosphere afterwards to fix, metal spraying, SEM observations.
(3) result of the test
Using dentine of the scanning electron microscopic observation dentine piece after toothpaste processing prepared by the present embodiment 1 and embodiment 2
The blocking effect of tubule, as a result as shown in Figure 2.
From the A figures in Fig. 2, the dentinal tubule of control group is hollow, has no that any tamper is present, dentine between pipe
Boundary clear；From the B figures in Fig. 2, the visible dentinal tubule of demineralization dentine group is hollow, and dentine dissolves between pipe, caliber
Increase, tube wall is more irregular；From the C figures in Fig. 2, the visible most dentinal tubules of 1 group of embodiment are blocked by paste material,
Degree differs, and dentine boundary is smudgy between sediment and pipe；From the D figures in Fig. 2,2 groups of dentinal tubules of embodiment
Diameter diminishes, and dentinal tubule is blocked by paste material, and material blocks closely knit, and dentine wiring is fuzzy not between sediment and pipe
Clearly.
Embodiment 9
The toothpaste that above-described embodiment 1 and embodiment 2 are prepared is applied to its body to incipient enamel caries tooth remineralization
Used investigation object is the dentine piece sample for meeting enamel demineralization in vitro study in outer research, the present embodiment.
(1) preparation of dentine piece：Collected in Stomatological Hospital, Military Surgeon Univ. No. 4's decorative sursery outpatient service because of orthodontic treatment (year
Age span 18-28 Sui, corona is complete, without dental caries are bad, flawless, without treatment of restoration nature) and the premolar teeth 30 pulled out (patient knows
Agree to), in cheek side, same position reserves 2mm × 2mm regions, and remainder is closed using nail polish.34% phosphorus is used using clinic
Acid gel acid etching enamel 2min, a large amount of deionized water rinsings are after ultrasound shake 5min in deionized water, into typical chalk after drying
Color demineralization changes, and the demineralization of simulation incipient enamel caries changes, and obtains the sample (demineralization enamel group) for meeting enamel demineralization research.
(2) the specific step of the dentine piece sample of the toothpaste processing enamel demineralization prepared using embodiment 1 and embodiment 2
Suddenly：Enamel demineralization is fixed on slide with tweezers, toothpaste prepared by 5.0g embodiments 1 and embodiment 2 is weighed respectively, plus
Toothpaste slurries are made in the stirring of 10.0g deionized waters, are coated on acid etching area surface, gently brush 2min manually with soft bristle tooth brush, quiet to put
2min；Then, with 20mL deionized water rinsings 3 times, it is put into 10mL artificial salivas and soaks, fresh artificial saliva is changed daily,
And deposit in 37 DEG C of insulating boxs, aforesaid operations are respectively as 2 groups of 1 group of embodiment and embodiment.1 group of daily Processing Example and
After the enamel specimen that 2 groups of embodiment 2 times, and the 2nd processing, in 37 DEG C of artificial salivas overnight.Continuous processing embodiment 1
The sample 14 of group, 2 groups of embodiment and demineralization enamel group；30s is scrubbed using distilled water, flowing water is rinsed to be done naturally in 30s, air
Dry laggard glutaraldehyde is fixed, metal spraying, SEM observations.
(3) result of the test
Using scanning electron microscopic observation enamel demineralization model after toothpaste processing prepared by the present embodiment 1 and embodiment 2 ore deposit again
The effect of change, as a result as shown in Figure 3.
From the A figures in Fig. 3, D figures and G figures, the enamel surface of demineralization enamel group is more visible to differ in size, justifies
The glaze space of shape, the i.e. demineralization of enamel fiber center；There is demineralization phenomenon around enamel fiber in some glaze tops；By the B figures in Fig. 3, E figures
With H figure understand, the enamel that 1 group of embodiment meet personally differ in size, shaped minerals mineralization in irregular shape, enamel surfaces compared with
It is smooth；From in Fig. 3 C figure, F figure and I figure, the enamel that 2 groups of embodiment meet personally differ in size, sheet in irregular shape
Mineral mineralization, enamel surfaces are more smooth.
Toothpaste prepared by 3-6 of the embodiment of the present invention is used for the shadow to exposure dentin mineralization, demineralization dentin mineralization
When sound and the in vitro study to incipient enamel caries tooth remineralization, result of the test is consistent with the result of embodiment 1 and embodiment 2.
Although the present invention is described in detail with a general description of the specific embodiments in this specification,
But on the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.
Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed model
Enclose.
Claims (10)
1. a kind of remineralization of teeth toothpaste, it is characterised in that include the raw material components of following percentage by weight：Wollastonite 3-5%,
Rubbing agent 20-60%, purificant 0.5-2%, wetting agent 20-40%, adhesive 1-5%, remaining is water.
2. remineralization of teeth toothpaste according to claim 1, it is characterised in that the wollastonite is wollastonite microballoon.
3. remineralization of teeth toothpaste according to claim 2, it is characterised in that a diameter of 1.0- of the wollastonite microballoon
3.0μm。
4. remineralization of teeth toothpaste according to claim 1, it is characterised in that the rubbing agent includes silica, Jiao
Calcium phosphate, sodium metaphosphate or calcium carbonate.
5. remineralization of teeth toothpaste according to claim 1, it is characterised in that the purificant is surfactant, bag
Containing Determination of Polyoxyethylene Non-ionic Surfactants or amphoteric surfactant.
6. remineralization of teeth toothpaste according to claim 5, it is characterised in that the polyoxyethylene-type non-ionic surface is lived
Property agent be polysorbate 20 or Cremophor RH40.
7. remineralization of teeth toothpaste according to claim 5, it is characterised in that the amphoteric surfactant is cocounut oil acyl
Aminocarbonyl propyl glycine betaine or lauryl glucosyl.
8. remineralization of teeth toothpaste according to claim 1, it is characterised in that the wetting agent be glycerine, sorbierite or
Propane diols.
9. remineralization of teeth toothpaste according to claim 1, it is characterised in that the adhesive is carboxymethyl cellulose
Sodium.
10. the preparation method of the remineralization of teeth toothpaste any one of claim 1-9, it is characterised in that including following
Step：
Step 1, adhesive is added in wetting agent, is uniformly mixed, obtains mixture A；
Step 2, wollastonite, purificant are dissolved in the water, are uniformly mixed, obtain mixture B；
Step 3, mixture A and mixture B are well mixed, and add rubbing agent, stirred, produce.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1377252A (en) * | 1999-08-05 | 2002-10-30 | 布洛克医药公司 | Composition for restoring defects in calcified tissues |
| CN1745743A (en) * | 2005-09-21 | 2006-03-15 | 美晨集团股份有限公司 | Toothpaste containing anion and cation surface activator and production thereof |
| CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
-
2017
- 2017-05-18 CN CN201710353596.7A patent/CN107157785A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1377252A (en) * | 1999-08-05 | 2002-10-30 | 布洛克医药公司 | Composition for restoring defects in calcified tissues |
| CN1745743A (en) * | 2005-09-21 | 2006-03-15 | 美晨集团股份有限公司 | Toothpaste containing anion and cation surface activator and production thereof |
| CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李小科等: "牙釉质再矿化综述", 《口腔护理用品工业》 * |
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