CA2385778A1 - Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e - Google Patents

Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e Download PDF

Info

Publication number
CA2385778A1
CA2385778A1 CA002385778A CA2385778A CA2385778A1 CA 2385778 A1 CA2385778 A1 CA 2385778A1 CA 002385778 A CA002385778 A CA 002385778A CA 2385778 A CA2385778 A CA 2385778A CA 2385778 A1 CA2385778 A1 CA 2385778A1
Authority
CA
Canada
Prior art keywords
epsilon
expression
cell
receptor
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002385778A
Other languages
English (en)
Inventor
Jean-Pierre Kinet
Emmanuel Donnadieu
Marie-Helene Jouvin
William Cookson
Miriam Fleur Moffatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Beth Israel Deaconess Medical Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2385778A1 publication Critical patent/CA2385778A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des procédés et des compositions apparentées de modulation de l'expression de surface d'une cellule réceptrice de haute affinité de l'immunoglobine E, le récepteur Fc.epsilon.RI. L'invention concerne également des procédés et des compostions apparentées pour le traitement et/ou la prévention d'états pathologiques causés par l'IgE tels que des états pathologiques allergiques.
CA002385778A 1999-09-21 2000-09-21 Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e Abandoned CA2385778A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15492499P 1999-09-21 1999-09-21
US60/154,924 1999-09-21
PCT/US2000/025877 WO2001021816A1 (fr) 1999-09-21 2000-09-21 Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e

Publications (1)

Publication Number Publication Date
CA2385778A1 true CA2385778A1 (fr) 2001-03-29

Family

ID=22553401

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002385778A Abandoned CA2385778A1 (fr) 1999-09-21 2000-09-21 Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e

Country Status (4)

Country Link
EP (1) EP1214429A1 (fr)
AU (1) AU7830500A (fr)
CA (1) CA2385778A1 (fr)
WO (1) WO2001021816A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192806A1 (fr) 2016-01-13 2017-07-19 Affiris AG Chaîne alpha du récepteur de l'ige haute affinité (fceria)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770396A (en) * 1992-04-16 1998-06-23 The United States Of America As Represented By The Department Of Health And Human Services Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E
WO1995005481A1 (fr) * 1993-08-18 1995-02-23 Isis Innovation Limited Procede de diagnostic et therapie

Also Published As

Publication number Publication date
AU7830500A (en) 2001-04-24
EP1214429A1 (fr) 2002-06-19
WO2001021816A1 (fr) 2001-03-29

Similar Documents

Publication Publication Date Title
Lowell et al. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Shimizu et al. IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages
US5565321A (en) Detection of mutations in a CD40 ligand gene
Dombrowicz et al. Allergy-associated FcRβ is a molecular amplifier of IgE-and IgG-mediated in vivo responses
Rajagopal et al. RIBP, a novel Rlk/Txk-and itk-binding adaptor protein that regulates T cell activation
EP1352961B1 (fr) Proteine de cellule synoviale
ES2308785T3 (es) Agentes terapeuticos y diagnosticos capaces de modular la sensibilidad celular a citoquinas.
US8163710B2 (en) Reduction of graft-versus-host disease by modulation of SHIP activity
KR20050084317A (ko) 인간 ｃｄ２０ 및(또는) ｃｄ１６을 발현하는 트랜스제닉마우스
Fung-Leung et al. Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.
CA2212376A1 (fr) Ink4c-p18 et ink4d-p19, inhibiteurs de kinases dependantes de cycline cdk4 et cdk6 et leurs utilisations
US20020137711A1 (en) Control of NK cell function and survival by modulation of SHIP activity
Bortell et al. The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse
CA2398660A1 (fr) Compositions et methodes relatives au cyr61
US6613320B1 (en) Defective CD4+T-cells that express active CD40-L
WO1998022584A1 (fr) GENE CODANT POUR LE RECEPTEUR C1q ET SON APPLICATION DANS L'AUGMENTATION DE LA DEFENSE DE L'HOTE
WO2008027807A2 (fr) Lutte contre les diabètes et l'obésité
US20020156013A1 (en) Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
CA2385778A1 (fr) Procede de modulation de l'expression de la surface d'une cellule receptrice de l'immunoglobine e
US20100015654A1 (en) Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells
JP2001523467A (ja) 炎症性疾患のトランスジェニックモデル
WO1999007854A2 (fr) Serine/threonine kinase et ses utilisations
US6660906B1 (en) Tpl2 transgenic knockout mice
Kumaresan et al. Molecular characterization of the rat NK cell receptor 2B4
US20030228677A1 (en) AMID protein, nucleic acid molecules, and uses thereof

Legal Events

Date Code Title Description
FZDE Discontinued