CA2383991A1 - Devices and methods for microorganism detection - Google Patents
Devices and methods for microorganism detection Download PDFInfo
- Publication number
- CA2383991A1 CA2383991A1 CA002383991A CA2383991A CA2383991A1 CA 2383991 A1 CA2383991 A1 CA 2383991A1 CA 002383991 A CA002383991 A CA 002383991A CA 2383991 A CA2383991 A CA 2383991A CA 2383991 A1 CA2383991 A1 CA 2383991A1
- Authority
- CA
- Canada
- Prior art keywords
- chambers
- chamber
- seal
- bacteriophage
- separated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 47
- 244000005700 microbiome Species 0.000 title claims description 21
- 238000001514 detection method Methods 0.000 title description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 28
- 230000004913 activation Effects 0.000 claims abstract description 14
- 238000004891 communication Methods 0.000 claims abstract description 11
- 241000894006 Bacteria Species 0.000 claims description 59
- 241001515965 unidentified phage Species 0.000 claims description 44
- 230000001580 bacterial effect Effects 0.000 claims description 30
- 239000003443 antiviral agent Substances 0.000 claims description 29
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 26
- 238000004166 bioassay Methods 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
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- 230000000840 anti-viral effect Effects 0.000 description 11
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- 230000003321 amplification Effects 0.000 description 7
- 238000003199 nucleic acid amplification method Methods 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 6
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- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
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- -1 hydrogen ions Chemical class 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
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- 241000191940 Staphylococcus Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000014670 detection of bacterium Effects 0.000 description 3
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- 239000008188 pellet Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
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- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000589876 Campylobacter Species 0.000 description 2
- 241000186216 Corynebacterium Species 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 102000002464 Galactosidases Human genes 0.000 description 2
- 108010093031 Galactosidases Proteins 0.000 description 2
- 241000186781 Listeria Species 0.000 description 2
- 241000219991 Lythraceae Species 0.000 description 2
- 241000186359 Mycobacterium Species 0.000 description 2
- 235000014360 Punica granatum Nutrition 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000607768 Shigella Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940121357 antivirals Drugs 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000002101 lytic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 108010065152 Coagulase Proteins 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101710121996 Hexon protein p72 Proteins 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- NUHCTOLBWMJMLX-UHFFFAOYSA-N bromothymol blue Chemical compound BrC1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=C(Br)C(O)=C(C(C)C)C=2)C)=C1C NUHCTOLBWMJMLX-UHFFFAOYSA-N 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 230000001320 lysogenic effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 229920001896 polybutyrate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15723799P | 1999-10-01 | 1999-10-01 | |
| US60/157,237 | 1999-10-01 | ||
| US09/434,586 | 1999-11-05 | ||
| US09/434,586 US6737266B1 (en) | 1999-10-01 | 1999-11-05 | Devices and methods for microorganism detection |
| PCT/US2000/026983 WO2001025395A1 (en) | 1999-10-01 | 2000-09-29 | Devices and methods for microorganism detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2383991A1 true CA2383991A1 (en) | 2001-04-12 |
Family
ID=26853933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002383991A Abandoned CA2383991A1 (en) | 1999-10-01 | 2000-09-29 | Devices and methods for microorganism detection |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6737266B1 (enExample) |
| EP (1) | EP1220890B1 (enExample) |
| JP (1) | JP2003511021A (enExample) |
| AU (1) | AU7842200A (enExample) |
| CA (1) | CA2383991A1 (enExample) |
| DE (1) | DE60018588T2 (enExample) |
| WO (1) | WO2001025395A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124355B2 (en) * | 2001-02-01 | 2012-02-28 | Biomerieux S.A. | Detection and identification of groups of bacteria |
| CA2476237A1 (en) * | 2002-02-11 | 2003-08-21 | Alexion Pharmaceuticals, Inc. | Methods and apparatus for whole cell panning |
| US8216780B2 (en) * | 2002-04-12 | 2012-07-10 | Microphage (Tm) Incorporated | Method for enhanced sensitivity in bacteriophage-based diagnostic assays |
| AU2003228505B2 (en) | 2002-04-12 | 2009-01-08 | Colorado School Of Mines | Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells |
| US20040102903A1 (en) * | 2002-11-27 | 2004-05-27 | Graessle Josef A. | Biological growth plate scanner |
| US7319031B2 (en) * | 2002-11-27 | 2008-01-15 | 3M Innovative Properties Company | Mounting platform for biological growth plate scanner |
| US7351574B2 (en) * | 2002-11-27 | 2008-04-01 | 3M Innovative Properties Company | Loading and ejection systems for biological growth plate scanner |
| US20040101954A1 (en) * | 2002-11-27 | 2004-05-27 | Graessle Josef A. | Back side plate illumination for biological growth plate scanner |
| US7298885B2 (en) * | 2002-11-27 | 2007-11-20 | 3M Innovative Properties Company | Biological growth plate scanner with automated image processing profile selection |
| US7496225B2 (en) * | 2003-09-04 | 2009-02-24 | 3M Innovative Properties Company | Biological growth plate scanner with automated intake |
| US7298886B2 (en) | 2003-09-05 | 2007-11-20 | 3M Innovative Properties Company | Counting biological agents on biological growth plates |
| JP5150856B2 (ja) * | 2007-06-15 | 2013-02-27 | マイクロファージ・インコーポレーテッド | バクテリオファージ増幅を向上させた微生物の検出方法 |
| US8697434B2 (en) | 2008-01-11 | 2014-04-15 | Colorado School Of Mines | Detection of phage amplification by SERS nanoparticles |
| WO2009111301A1 (en) * | 2008-03-04 | 2009-09-11 | 3M Innovative Properties Company | Information management in automated processing of biological growth media |
| EP2265733A4 (en) * | 2008-03-04 | 2017-12-13 | 3M Innovative Properties Company | Processing of biological growth media based on measured manufacturing characteristics |
| US9441204B2 (en) | 2008-04-03 | 2016-09-13 | Colorado School Of Mines | Compositions and methods for detecting Yersinia pestis bacteria |
| JP2011178720A (ja) * | 2010-03-01 | 2011-09-15 | Nbc Meshtec Inc | 無機系抗ウイルス剤及びこの無機系抗ウイルス剤を含有した抗ウイルス部材 |
| CN105378060B (zh) | 2013-03-13 | 2019-12-10 | 经纬生物科技有限公司 | 非复制型转导颗粒和基于转导颗粒的报告系统 |
| US9481903B2 (en) | 2013-03-13 | 2016-11-01 | Roche Molecular Systems, Inc. | Systems and methods for detection of cells using engineered transduction particles |
| US9540675B2 (en) | 2013-10-29 | 2017-01-10 | GeneWeave Biosciences, Inc. | Reagent cartridge and methods for detection of cells |
| US10351893B2 (en) | 2015-10-05 | 2019-07-16 | GeneWeave Biosciences, Inc. | Reagent cartridge for detection of cells |
| US11077444B2 (en) | 2017-05-23 | 2021-08-03 | Roche Molecular Systems, Inc. | Packaging for a molecular diagnostic cartridge |
| KR102065620B1 (ko) * | 2019-01-21 | 2020-01-13 | 주식회사 마이크로진 | 박테리오파지를 이용한 식중독 세균 검출 키트 및 이를 이용한 검출방법 |
| DE102019134489B4 (de) * | 2019-12-16 | 2024-08-22 | Fachhochschule Südwestfalen, Köperschaft des öffentlichen Rechts | Phagenkultivierungsvorrichtung, Verfahren zur Präparation von Phagen und Filtervorrichtung dafür |
| WO2022067162A1 (en) * | 2020-09-25 | 2022-03-31 | Charm Sciences, Inc. | Sample preparation and detection systems and methods |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3290017A (en) | 1964-10-01 | 1966-12-06 | Henry K Davies | Barrier-mixer for tubular containers |
| US4364474A (en) | 1976-09-02 | 1982-12-21 | John P. Glass | Packages |
| US4632244A (en) | 1986-02-19 | 1986-12-30 | Boris Landau | Multiple chamber flexible container |
| US4690801A (en) | 1986-06-03 | 1987-09-01 | Allelix Inc. | Device for performing enzyme immunoassays |
| US4770853A (en) * | 1986-12-03 | 1988-09-13 | New Horizons Diagnostics Corporation | Device for self contained solid phase immunodiffusion assay |
| US4939152A (en) | 1987-09-30 | 1990-07-03 | Syntex (U.S.A.) Inc. | Cell culture vial |
| EP0406551B1 (en) | 1989-07-07 | 1994-03-16 | Omniglow Corporation | Chemiluminescent lighting element |
| GB9017443D0 (en) | 1990-08-09 | 1990-09-26 | Amersham Int Plc | Reporter bacteria for rapid microbial detection |
| ES2074612T3 (es) | 1990-08-30 | 1995-09-16 | Omniglow Corp | Elemento de alumbrado quimioluminiscente. |
| US5403622A (en) | 1992-07-07 | 1995-04-04 | Konica Corporation | Method for feeding a coating solution |
| WO1994026414A1 (en) | 1993-05-17 | 1994-11-24 | Syntex (U.S.A.) Inc. | Reaction container for specific binding assays and method for its use |
| US5508893A (en) | 1994-02-08 | 1996-04-16 | Rhode Island Novelty Company, Inc. | Multi-color chemiluminescent lighting device and method of making same |
| US5840308A (en) | 1994-02-17 | 1998-11-24 | Merck Patent Gmbh | Antiviral or antifungal composition comprising an extract of pomegranate rind or other plants and method of use |
| US5573951A (en) * | 1995-06-07 | 1996-11-12 | Accumed, Inc. | Dual chamber blood culture bottle with rotating inlet valve assembly |
| US6168079B1 (en) | 1996-06-26 | 2001-01-02 | Telxon Corporation | Customer information terminal system with a docking member for a data collection device |
| FR2759348B1 (fr) * | 1997-02-07 | 1999-04-16 | Biodome | Recipient distributeur multichambre pour le stockage d'au moins deux substances, le melange extemporane de celle-ci et la distribution du melange |
| US5958675A (en) | 1997-04-18 | 1999-09-28 | 3M Innovative Properties Company | Method for detecting bacteria using bacteriophage, contrast-coloring dye and precipitable dye |
| EP0896792A1 (en) | 1997-08-13 | 1999-02-17 | Julphar Pharma GmbH | Antiviral agent |
-
1999
- 1999-11-05 US US09/434,586 patent/US6737266B1/en not_active Expired - Fee Related
-
2000
- 2000-09-29 DE DE60018588T patent/DE60018588T2/de not_active Expired - Fee Related
- 2000-09-29 EP EP00968522A patent/EP1220890B1/en not_active Expired - Lifetime
- 2000-09-29 WO PCT/US2000/026983 patent/WO2001025395A1/en not_active Ceased
- 2000-09-29 CA CA002383991A patent/CA2383991A1/en not_active Abandoned
- 2000-09-29 AU AU78422/00A patent/AU7842200A/en not_active Abandoned
- 2000-09-29 JP JP2001528550A patent/JP2003511021A/ja not_active Withdrawn
-
2004
- 2004-04-05 US US10/818,092 patent/US7001719B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60018588T2 (de) | 2006-01-12 |
| JP2003511021A (ja) | 2003-03-25 |
| EP1220890B1 (en) | 2005-03-09 |
| EP1220890A1 (en) | 2002-07-10 |
| AU7842200A (en) | 2001-05-10 |
| US7001719B2 (en) | 2006-02-21 |
| WO2001025395A1 (en) | 2001-04-12 |
| US6737266B1 (en) | 2004-05-18 |
| US20040191892A1 (en) | 2004-09-30 |
| DE60018588D1 (de) | 2005-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |