CA2383650A1 - Mesoprogestines (modulateurs de recepteur de progesterone) comme composants de contraceptifs feminins - Google Patents
Mesoprogestines (modulateurs de recepteur de progesterone) comme composants de contraceptifs feminins Download PDFInfo
- Publication number
- CA2383650A1 CA2383650A1 CA002383650A CA2383650A CA2383650A1 CA 2383650 A1 CA2383650 A1 CA 2383650A1 CA 002383650 A CA002383650 A CA 002383650A CA 2383650 A CA2383650 A CA 2383650A CA 2383650 A1 CA2383650 A1 CA 2383650A1
- Authority
- CA
- Canada
- Prior art keywords
- mesoprogestin
- estrogen
- use according
- administration
- dosage units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne l'utilisation de mésoprogestines destinée à la production d'un produit pharmaceutique pour contraception féminine, une préparation pharmaceutique destinée à la contraception féminine ainsi qu'un procédé de contraception féminine par administration de quantités effectives de mésoprogestine dans une contraception féminine recherchée. La mésoprogestine peut, éventuellement, être utilisée en combinaison avec un oestrogène. Les mésoprogestines sont définies comme des composés possédant à la fois des activités agonistes et antagonistes au récepteur de progestérone (PR) in vivo. Elles stabilisent la fonction du PR à un niveau intermédiaire d'activité agoniste et antagoniste. On ne peut pas obtenir des états fonctionnels correspondants avec des progestines ou des antiprogestines. Selon l'invention, les mésoprogestines préférées sont les J867, J912, J956 et J1042.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38613399A | 1999-08-31 | 1999-08-31 | |
US09/386,133 | 1999-08-31 | ||
PCT/IB2000/002053 WO2001026603A2 (fr) | 1999-08-31 | 2000-08-31 | Mesoprogestines (modulateurs de recepteur de progesterone) comme composants de contraceptifs feminins |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2383650A1 true CA2383650A1 (fr) | 2001-04-19 |
Family
ID=23524305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002383650A Abandoned CA2383650A1 (fr) | 1999-08-31 | 2000-08-31 | Mesoprogestines (modulateurs de recepteur de progesterone) comme composants de contraceptifs feminins |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP1605949A2 (fr) |
JP (1) | JP2003511399A (fr) |
KR (1) | KR20020038745A (fr) |
CN (1) | CN1384748A (fr) |
AR (1) | AR025455A1 (fr) |
AU (1) | AU781835B2 (fr) |
BG (1) | BG106441A (fr) |
BR (1) | BR0013711A (fr) |
CA (1) | CA2383650A1 (fr) |
CO (1) | CO5190694A1 (fr) |
CZ (1) | CZ2002707A3 (fr) |
EA (1) | EA006805B1 (fr) |
EE (1) | EE200200103A (fr) |
HR (1) | HRP20020265A2 (fr) |
HU (1) | HUP0202515A3 (fr) |
IL (1) | IL148415A0 (fr) |
LT (1) | LT5001B (fr) |
LV (1) | LV12940B (fr) |
MX (1) | MXPA02002186A (fr) |
NO (1) | NO20020998L (fr) |
NZ (1) | NZ517470A (fr) |
PE (1) | PE20010579A1 (fr) |
PL (1) | PL353994A1 (fr) |
SI (1) | SI20853A (fr) |
SK (1) | SK2982002A3 (fr) |
UA (1) | UA77150C2 (fr) |
WO (1) | WO2001026603A2 (fr) |
YU (1) | YU13902A (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10236405A1 (de) | 2002-08-02 | 2004-02-19 | Schering Ag | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie |
DK1525215T3 (da) * | 2002-08-02 | 2007-01-15 | Schering Ag | Modulatorer for receptoren for progesteron med forhöjet anti-gonadotrop aktivitet til fertilitetskontrol hos kvinder og ved terapi til erstatning af hormoner |
US7772219B2 (en) * | 2003-05-02 | 2010-08-10 | Teva Women's Health, Inc. | Methods of hormonal treatment utilizing extended cycle contraceptive regimens |
US20050215535A1 (en) * | 2004-03-24 | 2005-09-29 | Kristof Chwalisz | Sequential SPRM/progestin treatment |
EP1773344A1 (fr) * | 2004-07-07 | 2007-04-18 | Wyeth a Corporation of the State of Delaware | Schémas cycliques de progestérone et trousses d"administration |
DE102005050729A1 (de) * | 2005-10-19 | 2007-04-26 | Schering Ag | Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption |
JP5951480B2 (ja) * | 2009-04-14 | 2016-07-13 | ラボラトワール・アシュエールア−ファルマLaboratoire Hra−Pharma | オンデマンド避妊方法 |
CN110548034A (zh) * | 2019-07-12 | 2019-12-10 | 广州莎蔓生物科技有限公司 | 一种怀孕阻断药物 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2054271A (en) | 1932-05-17 | 1936-09-15 | Schering Kahlbaum Ag | Production of crystallized hormone esters |
DE699310C (de) | 1936-11-20 | 1940-11-27 | Chemische Ind Ges | Verfahren zur Herstellung von in 3-Stellung veresterten Verbindungen vom Typus des Oestradiols |
US2225419A (en) | 1937-03-01 | 1940-12-17 | Schering Corp | Process for the conversion of 17-cisalcohols of the cyclopentanopolyhydrophenanthrene series into the corresponding 17-trans-alcohols |
US2611773A (en) | 1951-08-21 | 1952-09-23 | Upjohn Co | Estradiol 17-cyclopenetanepropionate |
US2990414A (en) | 1957-03-26 | 1961-06-27 | Syntex Sa | 17-undecenoate of estradiol |
DE3337450A1 (de) | 1983-10-12 | 1985-04-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prostaglandine und antigestagene fuer den schwangerschaftsabbruch |
NZ226316A (en) * | 1987-09-24 | 1991-10-25 | Jencap Research Ltd | Pharmaceutical contraceptive preparations and packages containing from 20-35 unit dosages comprising an estrogen and a progestin; the unit dosages having alternating estrogen and progestin dominance |
US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
US5516769A (en) | 1993-02-19 | 1996-05-14 | The Medical College Of Hampton Roads | Method of inhibiting fertilization |
DE4332284C2 (de) * | 1993-09-20 | 1997-05-28 | Jenapharm Gmbh | 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE4429397C2 (de) | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
DE4429398C2 (de) | 1994-08-09 | 1997-09-11 | Jenapharm Gmbh | Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption |
ATE347894T1 (de) * | 1994-10-24 | 2007-01-15 | Schering Ag | Kompetitive progesteronantagonisten zur bedarfsorientierten weiblichen fertilitätskontrolle |
US6040340A (en) * | 1996-05-07 | 2000-03-21 | Schering Aktiengesellschaft | Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors |
AU725670B2 (en) * | 1996-06-25 | 2000-10-19 | Akzo Nobel N.V. | Progestogen-anti-progestogen regimens |
WO1998005679A2 (fr) * | 1996-08-05 | 1998-02-12 | Duke University | Antagonistes mixtes du recepteur progesterone et techniques de dosage associees |
DE19809845A1 (de) * | 1998-03-03 | 1999-09-09 | Jenapharm Gmbh | S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
AU4501800A (en) * | 1999-05-04 | 2000-11-17 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
-
2000
- 2000-08-31 IL IL14841500A patent/IL148415A0/xx unknown
- 2000-08-31 AR ARP000104536A patent/AR025455A1/es unknown
- 2000-08-31 CO CO00065517A patent/CO5190694A1/es not_active Application Discontinuation
- 2000-08-31 CA CA002383650A patent/CA2383650A1/fr not_active Abandoned
- 2000-08-31 MX MXPA02002186A patent/MXPA02002186A/es not_active Application Discontinuation
- 2000-08-31 UA UA2002032429A patent/UA77150C2/uk unknown
- 2000-08-31 EA EA200200284A patent/EA006805B1/ru not_active IP Right Cessation
- 2000-08-31 KR KR1020027002785A patent/KR20020038745A/ko not_active Application Discontinuation
- 2000-08-31 JP JP2001529395A patent/JP2003511399A/ja active Pending
- 2000-08-31 WO PCT/IB2000/002053 patent/WO2001026603A2/fr not_active Application Discontinuation
- 2000-08-31 PE PE2000000894A patent/PE20010579A1/es not_active Application Discontinuation
- 2000-08-31 AU AU32150/01A patent/AU781835B2/en not_active Ceased
- 2000-08-31 PL PL00353994A patent/PL353994A1/xx not_active Application Discontinuation
- 2000-08-31 EE EEP200200103A patent/EE200200103A/xx unknown
- 2000-08-31 CZ CZ2002707A patent/CZ2002707A3/cs unknown
- 2000-08-31 CN CN00812308A patent/CN1384748A/zh active Pending
- 2000-08-31 HU HU0202515A patent/HUP0202515A3/hu unknown
- 2000-08-31 NZ NZ517470A patent/NZ517470A/en unknown
- 2000-08-31 YU YU13902A patent/YU13902A/sh unknown
- 2000-08-31 EP EP00991299A patent/EP1605949A2/fr not_active Withdrawn
- 2000-08-31 SK SK298-2002A patent/SK2982002A3/sk unknown
- 2000-08-31 SI SI200020043A patent/SI20853A/sl not_active IP Right Cessation
- 2000-08-31 BR BR0013711-1A patent/BR0013711A/pt not_active IP Right Cessation
-
2002
- 2002-02-26 BG BG06441A patent/BG106441A/bg unknown
- 2002-02-28 NO NO20020998A patent/NO20020998L/no not_active Application Discontinuation
- 2002-03-26 LT LT2002035A patent/LT5001B/lt not_active IP Right Cessation
- 2002-03-28 LV LVP-02-52A patent/LV12940B/en unknown
- 2002-03-28 HR HR20020265A patent/HRP20020265A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SI20853A (sl) | 2002-10-31 |
NO20020998D0 (no) | 2002-02-28 |
LT5001B (lt) | 2003-03-25 |
EA006805B1 (ru) | 2006-04-28 |
LV12940B (en) | 2003-06-20 |
BG106441A (bg) | 2002-09-30 |
KR20020038745A (ko) | 2002-05-23 |
MXPA02002186A (es) | 2002-09-02 |
CZ2002707A3 (cs) | 2002-11-13 |
CN1384748A (zh) | 2002-12-11 |
YU13902A (sh) | 2006-01-16 |
PE20010579A1 (es) | 2001-06-04 |
CO5190694A1 (es) | 2002-08-29 |
JP2003511399A (ja) | 2003-03-25 |
SK2982002A3 (en) | 2002-07-02 |
PL353994A1 (en) | 2003-12-15 |
WO2001026603A2 (fr) | 2001-04-19 |
AR025455A1 (es) | 2002-11-27 |
EE200200103A (et) | 2003-04-15 |
LT2002035A (lt) | 2002-10-25 |
EP1605949A2 (fr) | 2005-12-21 |
HUP0202515A3 (en) | 2004-06-28 |
HRP20020265A2 (en) | 2004-02-29 |
IL148415A0 (en) | 2002-09-12 |
NZ517470A (en) | 2004-03-26 |
HUP0202515A2 (hu) | 2002-12-28 |
WO2001026603A3 (fr) | 2002-01-17 |
EA200200284A1 (ru) | 2002-10-31 |
AU3215001A (en) | 2001-04-23 |
BR0013711A (pt) | 2002-05-07 |
NO20020998L (no) | 2002-03-14 |
UA77150C2 (en) | 2006-11-15 |
AU781835B2 (en) | 2005-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |