CA2381926A1 - Marqueurs inflammatoires systemiques en tant qu'outils diagnostiques dans la prevention des maladies atherosclereuses - Google Patents

Marqueurs inflammatoires systemiques en tant qu'outils diagnostiques dans la prevention des maladies atherosclereuses Download PDF

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Publication number
CA2381926A1
CA2381926A1 CA002381926A CA2381926A CA2381926A1 CA 2381926 A1 CA2381926 A1 CA 2381926A1 CA 002381926 A CA002381926 A CA 002381926A CA 2381926 A CA2381926 A CA 2381926A CA 2381926 A1 CA2381926 A1 CA 2381926A1
Authority
CA
Canada
Prior art keywords
agent
subject
risk
sodium
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002381926A
Other languages
English (en)
Inventor
Paul Ridker
Charles H. Hennekens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/387,028 external-priority patent/US7030152B1/en
Application filed by Individual filed Critical Individual
Publication of CA2381926A1 publication Critical patent/CA2381926A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés servant à caractériser, chez un individu, un profil de risque de développement futur d'une maladie cardio-vasculaire, et consistant à obtenir un niveau du marqueur d'inflammation systémique de cet individu. L'invention concerne également des procédés d'évaluation de la possibilité qu'un traitement, à base d'un agent réduisant le risque de développement futur d'une maladie cardio-vasculaire, va être bénéfique pour un individu.
CA002381926A 1999-08-31 2000-08-31 Marqueurs inflammatoires systemiques en tant qu'outils diagnostiques dans la prevention des maladies atherosclereuses Abandoned CA2381926A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/387,028 US7030152B1 (en) 1997-04-02 1999-08-31 Systematic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease
US09/387,028 1999-08-31
PCT/US2000/024251 WO2001015744A1 (fr) 1999-08-31 2000-08-31 Marqueurs inflammatoires systemiques en tant qu'outils diagnostiques dans la prevention des maladies atherosclereuses

Publications (1)

Publication Number Publication Date
CA2381926A1 true CA2381926A1 (fr) 2001-03-08

Family

ID=23528141

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002381926A Abandoned CA2381926A1 (fr) 1999-08-31 2000-08-31 Marqueurs inflammatoires systemiques en tant qu'outils diagnostiques dans la prevention des maladies atherosclereuses

Country Status (5)

Country Link
EP (1) EP1212101A1 (fr)
JP (1) JP2003508453A (fr)
AU (1) AU782386C (fr)
CA (1) CA2381926A1 (fr)
WO (1) WO2001015744A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2464531A1 (fr) 2001-11-05 2003-05-15 Brigham And Women's Hospital, Inc. Cd40l(cd154) soluble en tant que marqueur pour le diagnostic de maladies d'atherosclerose
AU2003231730A1 (en) * 2002-05-03 2003-11-17 Alcon, Inc. Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac
GB0229747D0 (en) 2002-12-20 2003-01-29 Axis Shield Asa Assay
US20050065184A1 (en) * 2003-08-29 2005-03-24 Aaipharma Inc. Method of reducing the risk of oxidative stress
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
WO2005110422A2 (fr) 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Procede pour traiter des maladies et des etats associes a un niveau modifie de peptides beta amyloides et nouveaux composes d'enolcarboxamide
JP5728488B2 (ja) 2009-11-13 2015-06-03 ビージー メディシン， インコーポレイテッド 心筋梗塞のリスクファクターおよび予測

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69829293T2 (de) * 1997-04-02 2006-04-13 The Brigham And Women's Hospital Inc., Boston Verwendung eines mittels zur verminderung des risikos kardiovaskulärer erkrankungen
AU745797B2 (en) * 1997-04-18 2002-03-28 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders

Also Published As

Publication number Publication date
WO2001015744A9 (fr) 2002-09-26
WO2001015744A1 (fr) 2001-03-08
EP1212101A1 (fr) 2002-06-12
JP2003508453A (ja) 2003-03-04
AU782386B2 (en) 2005-07-21
AU7110300A (en) 2001-03-26
AU782386C (en) 2006-08-10

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead