CA2379834A1 - Agents therapeutiques anti-infectieux catalyses par des enzymes - Google Patents

Agents therapeutiques anti-infectieux catalyses par des enzymes Download PDF

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Publication number
CA2379834A1
CA2379834A1 CA002379834A CA2379834A CA2379834A1 CA 2379834 A1 CA2379834 A1 CA 2379834A1 CA 002379834 A CA002379834 A CA 002379834A CA 2379834 A CA2379834 A CA 2379834A CA 2379834 A1 CA2379834 A1 CA 2379834A1
Authority
CA
Canada
Prior art keywords
group
cell
enzyme
prodrug
activating enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002379834A
Other languages
English (en)
Inventor
H. Michael Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celmed Oncology USA Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2379834A1 publication Critical patent/CA2379834A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/556—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells enzyme catalyzed therapeutic agent [ECTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne une méthode permettant d'inhiber sélectivement un agent infectieux ou une cellule infectée par un agent infectieux en mettant ledit agent infectieux ou ladite cellule infectée par l'agent en contact avec un promédicament qui est sélectivement converti en une toxine au moyen d'un enzyme d'activation exprimé par l'agent infectieux. Cet enzyme d'activation est sélectif pour l'enzyme exprimé par l'agent infectieux en comparaison avec l'enzyme identique ou similaire exprimé par la cellule hôte ou d'autres agents infectieux. L'agent d'activation n'est ni inhibé ni inactivé par le promédicament. L'invention concerne également des cribles permettant d'identifier des promédicaments.
CA002379834A 1999-07-22 2000-07-21 Agents therapeutiques anti-infectieux catalyses par des enzymes Abandoned CA2379834A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14536499P 1999-07-22 1999-07-22
US60/145,364 1999-07-22
US15310199P 1999-09-09 1999-09-09
US60/153,101 1999-09-09
PCT/US2000/019844 WO2001007087A2 (fr) 1999-07-22 2000-07-21 Agents therapeutiques anti-infectieux catalyses par des enzymes

Publications (1)

Publication Number Publication Date
CA2379834A1 true CA2379834A1 (fr) 2001-02-01

Family

ID=26842894

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002379834A Abandoned CA2379834A1 (fr) 1999-07-22 2000-07-21 Agents therapeutiques anti-infectieux catalyses par des enzymes

Country Status (9)

Country Link
EP (1) EP1202749A2 (fr)
JP (1) JP2003527317A (fr)
KR (1) KR20020059340A (fr)
CN (1) CN1391487A (fr)
AU (1) AU6358900A (fr)
CA (1) CA2379834A1 (fr)
IL (1) IL147747A0 (fr)
MX (1) MXPA02000761A (fr)
WO (1) WO2001007087A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
US6703374B1 (en) 1997-10-30 2004-03-09 The United States Of America As Represented By The Department Of Health And Human Services Nucleosides for imaging and treatment applications
IL147749A0 (en) * 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors
GB0009486D0 (en) 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
WO2002007780A2 (fr) * 2000-07-20 2002-01-31 Newbiotics, Inc. Procedes d'identification de cibles therapeutiques destinees a traiter des maladies infectieuses
US6987180B2 (en) 2002-02-07 2006-01-17 President And Fellows Of Harvard College Uridine analogs and techniques for making and using
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
CN104497083B (zh) * 2014-05-12 2017-07-07 河南师范大学 具有抗寄生虫活性的核苷‑苯基丙烯酮杂化体及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323008D0 (en) * 1993-11-05 1994-01-05 Connors Thomas Improvements relating to cancer therapy
WO1999006072A1 (fr) * 1997-07-30 1999-02-11 Boehringer Mannheim Corporation Promedicaments cyclises
TWI244924B (en) * 1998-01-23 2005-12-11 Newbiotics Inc Enzyme catalyzed therapeutic agents
PT1144011E (pt) * 1998-12-11 2010-06-16 Coulter Pharm Inc Compostos pró-fármacos e processo para a sua preparação
IL147749A0 (en) * 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors

Also Published As

Publication number Publication date
WO2001007087A8 (fr) 2001-07-12
AU6358900A (en) 2001-02-13
IL147747A0 (en) 2002-08-14
JP2003527317A (ja) 2003-09-16
KR20020059340A (ko) 2002-07-12
WO2001007087A3 (fr) 2002-01-17
MXPA02000761A (es) 2002-08-12
WO2001007087A2 (fr) 2001-02-01
EP1202749A2 (fr) 2002-05-08
CN1391487A (zh) 2003-01-15

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CA2379834A1 (fr) Agents therapeutiques anti-infectieux catalyses par des enzymes
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Legal Events

Date Code Title Description
FZDE Discontinued