CA2378600A1 - Composes de type amino-ceramide et procedes therapeutiques d'utilisation - Google Patents

Composes de type amino-ceramide et procedes therapeutiques d'utilisation Download PDF

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Publication number
CA2378600A1
CA2378600A1 CA002378600A CA2378600A CA2378600A1 CA 2378600 A1 CA2378600 A1 CA 2378600A1 CA 002378600 A CA002378600 A CA 002378600A CA 2378600 A CA2378600 A CA 2378600A CA 2378600 A1 CA2378600 A1 CA 2378600A1
Authority
CA
Canada
Prior art keywords
phenyl
pyrrolidino
propanol
palmitoylamino
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002378600A
Other languages
English (en)
Inventor
Norman S. Radin
James A. Shayman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/350,768 external-priority patent/US6255336B1/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US2000/018935 external-priority patent/WO2001004108A1/fr
Publication of CA2378600A1 publication Critical patent/CA2378600A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne de nouveaux composés (1) de type amino-céramide qui inhibent la formation de glucosyle céramide (GlcCer) en inhibant l'enzyme GlcCer synthase et en abaissant de ce fait le taux de glycosphingolipides. Les composés de la présente invention améliorent l'activité d'inhibition de la ClcCer synthase et sont par conséquent particulièrement utiles dans les procédés thérapeutiques destinés à traiter divers états et maladies associées à une altération des taux de glycosphingolipides.
CA002378600A 1999-07-09 2000-07-07 Composes de type amino-ceramide et procedes therapeutiques d'utilisation Abandoned CA2378600A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/350,678 1999-07-09
US09/350,768 US6255336B1 (en) 1995-09-20 1999-07-09 Amino ceramide-like compounds and therapeutic methods of use
PCT/US2000/018935 WO2001004108A1 (fr) 1999-07-09 2000-07-07 Composes de type amino-ceramide et procedes therapeutiques d'utilisation
CA002454453A CA2454453A1 (fr) 2000-07-07 2003-12-24 Composes de type aminoceramide et methodes therapeutiques d'utilisation

Publications (1)

Publication Number Publication Date
CA2378600A1 true CA2378600A1 (fr) 2001-01-18

Family

ID=56290039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002378600A Abandoned CA2378600A1 (fr) 1999-07-09 2000-07-07 Composes de type amino-ceramide et procedes therapeutiques d'utilisation

Country Status (6)

Country Link
EP (1) EP1196406A1 (fr)
JP (1) JP2003521479A (fr)
AU (1) AU774960B2 (fr)
BR (1) BR0012318A (fr)
CA (1) CA2378600A1 (fr)
MX (1) MXPA02000296A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116239513A (zh) * 2023-05-05 2023-06-09 天津凯莱英制药有限公司 Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1811991B1 (fr) * 2004-11-10 2018-11-07 Genzyme Corporation Traitement du diabete de type 2 en utilisant d'inhibiteurs de la synthese des glycosphingolipides
KR20160085917A (ko) * 2007-10-05 2016-07-18 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
CN102271678B (zh) * 2008-10-03 2017-06-30 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂
SI2796457T1 (sl) * 2009-11-27 2016-10-28 Genzyme Corporation Genz 112638 za zdravljenje Gaucherjeve ali Fabryjeve bolezni v kombinirani terapiji

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010817A1 (fr) * 1995-09-20 1997-03-27 The Regents Of The University Of Michigan Composes de type amino ceramide et leurs methodes d'utilisation therapeutiques

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116239513A (zh) * 2023-05-05 2023-06-09 天津凯莱英制药有限公司 Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物
CN116239513B (zh) * 2023-05-05 2023-08-18 天津凯莱英制药有限公司 Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物

Also Published As

Publication number Publication date
AU5929600A (en) 2001-01-30
EP1196406A1 (fr) 2002-04-17
AU774960B2 (en) 2004-07-15
JP2003521479A (ja) 2003-07-15
MXPA02000296A (es) 2004-05-21
BR0012318A (pt) 2002-05-28

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