CA2376487A1 - Methods for enhancing the production of cytokines in cell culture - Google Patents

Methods for enhancing the production of cytokines in cell culture Download PDF

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Publication number
CA2376487A1
CA2376487A1 CA002376487A CA2376487A CA2376487A1 CA 2376487 A1 CA2376487 A1 CA 2376487A1 CA 002376487 A CA002376487 A CA 002376487A CA 2376487 A CA2376487 A CA 2376487A CA 2376487 A1 CA2376487 A1 CA 2376487A1
Authority
CA
Canada
Prior art keywords
cytokine
expression
cells
pkr
cell line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376487A
Other languages
English (en)
French (fr)
Inventor
Allan S. Lau
Laura Browning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetrol Biotherapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376487A1 publication Critical patent/CA2376487A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002376487A 1999-06-15 2000-06-14 Methods for enhancing the production of cytokines in cell culture Abandoned CA2376487A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13931399P 1999-06-15 1999-06-15
US60/139,313 1999-06-15
PCT/US2000/040199 WO2000077236A2 (en) 1999-06-15 2000-06-14 Methods for enhancing the production of cytokines in cell cultur e

Publications (1)

Publication Number Publication Date
CA2376487A1 true CA2376487A1 (en) 2000-12-21

Family

ID=22486056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376487A Abandoned CA2376487A1 (en) 1999-06-15 2000-06-14 Methods for enhancing the production of cytokines in cell culture

Country Status (7)

Country Link
EP (1) EP1255848A2 (ja)
JP (1) JP2003509012A (ja)
CN (1) CN1399681A (ja)
AU (1) AU6403700A (ja)
CA (1) CA2376487A1 (ja)
HK (1) HK1048650A1 (ja)
WO (1) WO2000077236A2 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031859A1 (en) * 1999-09-08 2001-10-18 Lau Allan S. High level cytokine production with enhanced cell viability
CA2422060A1 (en) * 2000-09-12 2002-03-21 Genetrol Biotherapeutics, Inc. Compositions comprising mixtures of human cytokines and methods of producing the same
AU2001290855A1 (en) 2000-09-14 2002-03-26 Genetrol Biotherapeutics, Inc. Method and cell composition for screening compounds for anti-inflammatory activity
JP2005500816A (ja) * 2000-12-19 2005-01-13 ジーントロール バイオセラピューティクス， インコーポレイテッド サイトカイン産生を増加するための増大したｐｋｒ発現を有する細胞
US20090232808A1 (en) * 2005-01-28 2009-09-17 Apollo Life Sciences Limited Molecules and chimeric molecules thereof
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018122147A1 (en) * 2017-01-02 2018-07-05 F. Hoffmann-La Roche Ag B-cell cultivation method
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
CA2130802A1 (en) * 1992-02-28 1993-09-02 Terry Strom Methods and compounds for prevention of graft rejection
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture

Also Published As

Publication number Publication date
CN1399681A (zh) 2003-02-26
JP2003509012A (ja) 2003-03-11
WO2000077236A3 (en) 2002-09-12
AU6403700A (en) 2001-01-02
HK1048650A1 (zh) 2003-04-11
WO2000077236A2 (en) 2000-12-21
EP1255848A2 (en) 2002-11-13

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FZDE Dead