CA2376357A1 - .mu.o-conopeptides et leur utilisation comme anesthesiques locaux - Google Patents

.mu.o-conopeptides et leur utilisation comme anesthesiques locaux Download PDF

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Publication number
CA2376357A1
CA2376357A1 CA002376357A CA2376357A CA2376357A1 CA 2376357 A1 CA2376357 A1 CA 2376357A1 CA 002376357 A CA002376357 A CA 002376357A CA 2376357 A CA2376357 A CA 2376357A CA 2376357 A1 CA2376357 A1 CA 2376357A1
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CA
Canada
Prior art keywords
tyr
cys
lys
ile
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376357A
Other languages
English (en)
Inventor
Baldomero M. Olivera
J. Michael Mcintosh
R. Tyler Mccabe
James E. Garrett
Richard T. Layer
John D. Wagstaff
Robert M. Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Cognetix Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376357A1 publication Critical patent/CA2376357A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne d'une part les nouveaux µO-conopeptides, leur séquences de codage, et leur propeptides, et d'autre part l'utilisation de ces µO-conopeptides comme anesthésiques locaux pour le traitement de la douleur. Ces µO-conopeptides, qui se distinguent par une action anesthésiante de longue durée, conviennent particulièrement pour l'anesthésie rachidienne, soit en administration aiguë contre la douleur post-opératoire, soit par pompe intrathécale pour les situations de douleur chronique sévère, ou pour le traitement de la douleur dans l'épithélium.
CA002376357A 1999-06-10 2000-06-09 .mu.o-conopeptides et leur utilisation comme anesthesiques locaux Abandoned CA2376357A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13850799P 1999-06-10 1999-06-10
US60/138,507 1999-06-10
PCT/US2000/015779 WO2000076532A1 (fr) 1999-06-10 2000-06-09 νO-CONOPEPTIDES ET LEUR UTILISATION COMME ANESTHESIQUES LOCAUX

Publications (1)

Publication Number Publication Date
CA2376357A1 true CA2376357A1 (fr) 2000-12-21

Family

ID=22482336

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376357A Abandoned CA2376357A1 (fr) 1999-06-10 2000-06-09 .mu.o-conopeptides et leur utilisation comme anesthesiques locaux

Country Status (5)

Country Link
EP (1) EP1185286A4 (fr)
JP (1) JP2003501109A (fr)
AU (1) AU5474200A (fr)
CA (1) CA2376357A1 (fr)
WO (1) WO2000076532A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396529A1 (fr) 1999-12-30 2001-07-12 University Of Utah Research Foundation Peptides designes superfamille o- de conotoxines
GB0011202D0 (en) * 2000-05-09 2000-06-28 Kci Licensing Inc Abdominal wound dressing
WO2002007756A1 (fr) * 2000-07-20 2002-01-31 Cognetix, Inc. $g(m)o-conopeptides et leur utilisation comme anesthesiques locaux
AU2001282945A1 (en) * 2000-07-21 2002-02-05 Cognetix, Inc Mu-conopeptides
CN101506225A (zh) * 2006-08-17 2009-08-12 埃里比斯药品公司 心脏保护化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
AU700592B2 (en) * 1995-04-17 1999-01-07 University Of Utah Research Foundation Conotoxin peptides
FR2785613B1 (fr) * 1998-11-10 2001-01-05 Commissariat Energie Atomique Conotoxine isolee a partir du venin de conus ermineus, ses analogues et ses applications

Also Published As

Publication number Publication date
EP1185286A4 (fr) 2004-09-08
AU5474200A (en) 2001-01-02
WO2000076532A1 (fr) 2000-12-21
EP1185286A1 (fr) 2002-03-13
JP2003501109A (ja) 2003-01-14

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Legal Events

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FZDE Dead